Citation
Li, Chuanhai, et al. "Integration of Metabolomics and Proteomics Reveals the Underlying Hepatotoxic Mechanism of Perfluorooctane Sulfonate (PFOS) and 6:2 Chlorinated Polyfluoroalkyl Ether Sulfonic Acid (6:2 Cl-PFESA) in Primary Human Hepatocytes." Ecotoxicology and Environmental Safety, vol. 249, 2023, p. 114361.
Li C, Jiang L, Qi Y, et al. Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in primary human hepatocytes. Ecotoxicol Environ Saf. 2023;249:114361.
Li, C., Jiang, L., Qi, Y., Zhang, D., Liu, X., Han, W., Ma, W., Xu, L., Jin, Y., Luo, J., Zhao, K., & Yu, D. (2023). Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in primary human hepatocytes. Ecotoxicology and Environmental Safety, 249, 114361. https://doi.org/10.1016/j.ecoenv.2022.114361
Li C, et al. Integration of Metabolomics and Proteomics Reveals the Underlying Hepatotoxic Mechanism of Perfluorooctane Sulfonate (PFOS) and 6:2 Chlorinated Polyfluoroalkyl Ether Sulfonic Acid (6:2 Cl-PFESA) in Primary Human Hepatocytes. Ecotoxicol Environ Saf. 2023 Jan 1;249:114361. PubMed PMID: 36508832.
TY - JOUR
T1 - Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in primary human hepatocytes.
AU - Li,Chuanhai,
AU - Jiang,Lidan,
AU - Qi,Yuan,
AU - Zhang,Donghui,
AU - Liu,Xinya,
AU - Han,Wenchao,
AU - Ma,Wanli,
AU - Xu,Lin,
AU - Jin,Yuan,
AU - Luo,Jiao,
AU - Zhao,Kunming,
AU - Yu,Dianke,
Y1 - 2022/12/09/
PY - 2022/04/06/received
PY - 2022/07/14/revised
PY - 2022/11/27/accepted
PY - 2022/12/13/pubmed
PY - 2022/12/13/medline
PY - 2022/12/12/entrez
KW - 6:2 Cl-PFESA
KW - Metabolomics
KW - PFOS
KW - Primary human hepatocytes
KW - Proteomics
SP - 114361
EP - 114361
JF - Ecotoxicology and environmental safety
JO - Ecotoxicol Environ Saf
VL - 249
N2 - Perfluorooctane sulfonate (PFOS) and its alternative 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA) are ubiquitous in various environmental and human samples. They have been reported to have hepatotoxicity effects, but the potential mechanisms remain unclear. Herein, we integrated metabolomics and proteomics analysis to investigate the altered profiles in metabolite and protein levels in primary human hepatocytes (PHH) exposed to 6:2 Cl-PFESA and PFOS at human exposure relevant concentrations. Our results showed that 6:2 Cl-PFESA exhibited higher perturbation effects on cell viability, metabolome and proteome than PFOS. Integration of metabolomics and proteomics revealed that the alteration of glycerophospholipid metabolism was the critical pathway of 6:2 Cl-PFESA and PFOS-induced lipid metabolism disorder in primary human hepatocytes. Interestingly, 6:2 Cl-PFESA-induced cellular metabolic process disorder was associated with the cellular membrane-bounded signaling pathway, while PFOS was associated with the intracellular transport process. Moreover, the disruption effects of 6:2 Cl-PFESA were also involved in inositol phosphate metabolism and phosphatidylinositol signaling system. Overall, this study provided comprehensive insights into the hepatic lipid toxicity mechanisms of 6:2 Cl-PFESA and PFOS in human primary hepatocytes.
SN - 1090-2414
UR - https://www.unboundmedicine.com/medline/citation/36508832/Integration_of_metabolomics_and_proteomics_reveals_the_underlying_hepatotoxic_mechanism_of_perfluorooctane_sulfonate__PFOS__and_6:2_chlorinated_polyfluoroalkyl_ether_sulfonic_acid__6:2_Cl_PFESA__in_primary_human_hepatocytes_
DB - PRIME
DP - Unbound Medicine
ER -
