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Haplotype and Genetic Analysis of 41 Y-STR Loci in the Wuwei Han Population from Gansu Province, China.
Curr Med Sci. 2023 Feb; 43(1):184-190.CM

Abstract

OBJECTIVE

Y-Chromosomal short tandem repeat polymorphism (Y-STR) analysis plays an indispensable role in the identification of male individuals, population genetics, and biogeographic research. While profiles of many populations based on Y-STR markers in human genomes are ample, haplotype data for the Wuwei Han are still scarce.

METHODS

In this study, 2180 unrelated Wuwei Han male individuals residing in Gansu Province, China were collected and genotyped using the novel Microreader™ 40Y Plus ID system. Phylogenetic relationship reconstructions, multidimensional scaling (MDS), and heatmap analysis were performed based on the genetic distance (Rst) values between our studied population and other populations of the Ymax module in the Y-STR Haplotype Reference Database (YHRD).

RESULTS

A total of 2129 unique haplotypes were obtained, and the haplotype diversity (HD) and discrimination capacity (DC) for the Wuwei Han were 0.9999 and 0.9931, respectively.

CONCLUSION

Our results demonstrate that the Wuwei Han population had intimate genetic relationships with East Asians, especially the geographically close Han populations. Overall, this Y-Chromosomal assay gives valuable information about paternal lineages in male individual tracking and genealogical database construction.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Li LY
Department of Pathology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Fan SG
The Judicial Authentication Center, Wuwei Public Security Bureau, Wuwei, 733000, China.
Gong H
Department of Pathology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Fan X
Department of Pathology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Wang DC
The Judicial Authentication Center, Wuwei Public Security Bureau, Wuwei, 733000, China.
Li NX
The Judicial Authentication Center, Wuwei Public Security Bureau, Wuwei, 733000, China.
Jia FQ
Department of Forensic Medicine, Inner Mongolia Medical University, Hohhot, 010059, China. jiafuquan915@163.com.

MeSH

HumansMaleHaplotypesPhylogenyEthnicityChromosomes, Human, YMicrosatellite RepeatsChina

Pub Type(s)

Journal Article

Language

eng

PubMed ID

36544037

Citation

Li, Lu-Yao, et al. "Haplotype and Genetic Analysis of 41 Y-STR Loci in the Wuwei Han Population From Gansu Province, China." Current Medical Science, vol. 43, no. 1, 2023, pp. 184-190.
Li LY, Fan SG, Gong H, et al. Haplotype and Genetic Analysis of 41 Y-STR Loci in the Wuwei Han Population from Gansu Province, China. Curr Med Sci. 2023;43(1):184-190.
Li, L. Y., Fan, S. G., Gong, H., Fan, X., Wang, D. C., Li, N. X., & Jia, F. Q. (2023). Haplotype and Genetic Analysis of 41 Y-STR Loci in the Wuwei Han Population from Gansu Province, China. Current Medical Science, 43(1), 184-190. https://doi.org/10.1007/s11596-022-2664-7
Li LY, et al. Haplotype and Genetic Analysis of 41 Y-STR Loci in the Wuwei Han Population From Gansu Province, China. Curr Med Sci. 2023;43(1):184-190. PubMed PMID: 36544037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haplotype and Genetic Analysis of 41 Y-STR Loci in the Wuwei Han Population from Gansu Province, China. AU - Li,Lu-Yao, AU - Fan,Sheng-Gui, AU - Gong,Hui, AU - Fan,Xing, AU - Wang,De-Chun, AU - Li,Neng-Xiu, AU - Jia,Fu-Quan, Y1 - 2022/12/22/ PY - 2022/5/19/received PY - 2022/9/6/accepted PY - 2022/12/22/pubmed PY - 2023/3/8/medline PY - 2022/12/21/entrez KW - Microreader™ 40Y Plus ID system KW - Wuwei Han KW - Y-InDel KW - Y-STR haplotype KW - population genetics SP - 184 EP - 190 JF - Current medical science JO - Curr Med Sci VL - 43 IS - 1 N2 - OBJECTIVE: Y-Chromosomal short tandem repeat polymorphism (Y-STR) analysis plays an indispensable role in the identification of male individuals, population genetics, and biogeographic research. While profiles of many populations based on Y-STR markers in human genomes are ample, haplotype data for the Wuwei Han are still scarce. METHODS: In this study, 2180 unrelated Wuwei Han male individuals residing in Gansu Province, China were collected and genotyped using the novel Microreader™ 40Y Plus ID system. Phylogenetic relationship reconstructions, multidimensional scaling (MDS), and heatmap analysis were performed based on the genetic distance (Rst) values between our studied population and other populations of the Ymax module in the Y-STR Haplotype Reference Database (YHRD). RESULTS: A total of 2129 unique haplotypes were obtained, and the haplotype diversity (HD) and discrimination capacity (DC) for the Wuwei Han were 0.9999 and 0.9931, respectively. CONCLUSION: Our results demonstrate that the Wuwei Han population had intimate genetic relationships with East Asians, especially the geographically close Han populations. Overall, this Y-Chromosomal assay gives valuable information about paternal lineages in male individual tracking and genealogical database construction. SN - 2523-899X UR - https://www.unboundmedicine.com/medline/citation/36544037/Haplotype_and_Genetic_Analysis_of_41_Y_STR_Loci_in_the_Wuwei_Han_Population_from_Gansu_Province_China_ DB - PRIME DP - Unbound Medicine ER -