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Small intestinal regulation of iron absorption in the rat.
J Lab Clin Med. 1987 Oct; 110(4):418-26.JL

Abstract

Ultrastructural, biochemical, and immunologic studies of the small intestinal mucosa of rats were undertaken to investigate factors associated with the regulation of iron absorption. The quantity of iron within mucosal cells was proportionate to the degree of iron repletion. Although the quantity of iron-binding substances was similar in iron-deficient and iron-loaded animals, the unsaturated iron-binding capacity of mucosal cells varied inversely with the state of iron repletion of animals in ultrastructural, biochemical, and immunologic observations. Although only certain mucosal cells contained iron-binding substances, their number was not increased in iron-deficient animals. Greater quantities of iron and iron-binding substances were observed in duodenal mucosa than in ileal mucosa. These findings are consistent with the hypothesis that the quantity of unsaturated iron-binding substances within intestinal mucosal cells regulates iron absorption. These findings are only partially explained by changes observed in the concentration of ferritin and transferrin within intestinal mucosa and suggest that other iron-binding substances may also participate in the regulation of iron absorption.

Authors+Show Affiliations

Department of Medicine, University of South Alabama, Mobile.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3655521

Citation

Conrad, M E., et al. "Small Intestinal Regulation of Iron Absorption in the Rat." The Journal of Laboratory and Clinical Medicine, vol. 110, no. 4, 1987, pp. 418-26.
Conrad ME, Parmley RT, Osterloh K. Small intestinal regulation of iron absorption in the rat. J Lab Clin Med. 1987;110(4):418-26.
Conrad, M. E., Parmley, R. T., & Osterloh, K. (1987). Small intestinal regulation of iron absorption in the rat. The Journal of Laboratory and Clinical Medicine, 110(4), 418-26.
Conrad ME, Parmley RT, Osterloh K. Small Intestinal Regulation of Iron Absorption in the Rat. J Lab Clin Med. 1987;110(4):418-26. PubMed PMID: 3655521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small intestinal regulation of iron absorption in the rat. AU - Conrad,M E, AU - Parmley,R T, AU - Osterloh,K, PY - 1987/10/1/pubmed PY - 1987/10/1/medline PY - 1987/10/1/entrez SP - 418 EP - 26 JF - The Journal of laboratory and clinical medicine JO - J Lab Clin Med VL - 110 IS - 4 N2 - Ultrastructural, biochemical, and immunologic studies of the small intestinal mucosa of rats were undertaken to investigate factors associated with the regulation of iron absorption. The quantity of iron within mucosal cells was proportionate to the degree of iron repletion. Although the quantity of iron-binding substances was similar in iron-deficient and iron-loaded animals, the unsaturated iron-binding capacity of mucosal cells varied inversely with the state of iron repletion of animals in ultrastructural, biochemical, and immunologic observations. Although only certain mucosal cells contained iron-binding substances, their number was not increased in iron-deficient animals. Greater quantities of iron and iron-binding substances were observed in duodenal mucosa than in ileal mucosa. These findings are consistent with the hypothesis that the quantity of unsaturated iron-binding substances within intestinal mucosal cells regulates iron absorption. These findings are only partially explained by changes observed in the concentration of ferritin and transferrin within intestinal mucosa and suggest that other iron-binding substances may also participate in the regulation of iron absorption. SN - 0022-2143 UR - https://www.unboundmedicine.com/medline/citation/3655521/Small_intestinal_regulation_of_iron_absorption_in_the_rat_ L2 - https://medlineplus.gov/iron.html DB - PRIME DP - Unbound Medicine ER -