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Pituitary-testicular axis in diabetic men with and without sexual impotence.
Diabete Metab. 1978 Dec; 4(4):233-7.DM

Abstract

In nine impotent diabetics (ID), eight diabetics with normal sexual function (ND), eight impotent non diabetics (IN) and seven normal patients (NN), we found normal basal FSH and LH levels. Plasma testosterone (T) values were significantly lower in ID and IN in comparison with NN and ND. After LHRH injection, plasma T increased in ID up to normal values. In non diabetic patients (NN and IN), LHRH induced a slight but significant rise in blood glucose. Post LHRH gonadotropins response was in the normal range for all groups and the amplitude of the response was highly correlated with basal levels except for LH in ND. Mean blood glucose during the test and LH response to LHRH were not inversely correlated in the patients studied. We conclude that impotence in diabetic patients is a neurological complication and that low testosterone levels are probably secondary to a decreased coital frequency. ID and IN probably share a common pattern of inadequate hypothalamic feedback control in the presence of low testosterone levels.

Authors

Daubresse JC
No affiliation info available
Meunier JC
No affiliation info available
Wilmotte J
No affiliation info available
Luyckx AS
No affiliation info available
Lefebvre PJ
No affiliation info available

MeSH

AdultBlood GlucoseDiabetes ComplicationsDiabetes MellitusErectile DysfunctionFollicle Stimulating HormoneGonadotropin-Releasing HormoneHumansKineticsLuteinizing HormoneMaleMiddle AgedPituitary GlandTestisTestosterone

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

365649

Citation

Daubresse, J C., et al. "Pituitary-testicular Axis in Diabetic Men With and Without Sexual Impotence." Diabete & Metabolisme, vol. 4, no. 4, 1978, pp. 233-7.
Daubresse JC, Meunier JC, Wilmotte J, et al. Pituitary-testicular axis in diabetic men with and without sexual impotence. Diabete Metab. 1978;4(4):233-7.
Daubresse, J. C., Meunier, J. C., Wilmotte, J., Luyckx, A. S., & Lefebvre, P. J. (1978). Pituitary-testicular axis in diabetic men with and without sexual impotence. Diabete & Metabolisme, 4(4), 233-7.
Daubresse JC, et al. Pituitary-testicular Axis in Diabetic Men With and Without Sexual Impotence. Diabete Metab. 1978;4(4):233-7. PubMed PMID: 365649.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pituitary-testicular axis in diabetic men with and without sexual impotence. AU - Daubresse,J C, AU - Meunier,J C, AU - Wilmotte,J, AU - Luyckx,A S, AU - Lefebvre,P J, PY - 1978/12/1/pubmed PY - 2000/3/11/medline PY - 1978/12/1/entrez SP - 233 EP - 7 JF - Diabete & metabolisme JO - Diabete Metab VL - 4 IS - 4 N2 - In nine impotent diabetics (ID), eight diabetics with normal sexual function (ND), eight impotent non diabetics (IN) and seven normal patients (NN), we found normal basal FSH and LH levels. Plasma testosterone (T) values were significantly lower in ID and IN in comparison with NN and ND. After LHRH injection, plasma T increased in ID up to normal values. In non diabetic patients (NN and IN), LHRH induced a slight but significant rise in blood glucose. Post LHRH gonadotropins response was in the normal range for all groups and the amplitude of the response was highly correlated with basal levels except for LH in ND. Mean blood glucose during the test and LH response to LHRH were not inversely correlated in the patients studied. We conclude that impotence in diabetic patients is a neurological complication and that low testosterone levels are probably secondary to a decreased coital frequency. ID and IN probably share a common pattern of inadequate hypothalamic feedback control in the presence of low testosterone levels. SN - 0338-1684 UR - https://www.unboundmedicine.com/medline/citation/365649/Pituitary_testicular_axis_in_diabetic_men_with_and_without_sexual_impotence_ DB - PRIME DP - Unbound Medicine ER -