TY - JOUR T1 - The diagnostic performance of antimullerian hormone for polycystic ovarian syndrome and polycystic ovarian morphology. AU - Vural,Fisun, AU - Vural,Birol, AU - Kardaş,Eyupcan, AU - Ertürk Coşkun,Ayşe Deniz, AU - Yildirim,İrem, Y1 - 2022/12/24/ PY - 2022/07/25/received PY - 2022/11/29/accepted PY - 2022/12/25/pubmed PY - 2023/3/22/medline PY - 2022/12/24/entrez KW - AMH KW - Anti mullerian hormone KW - Hirsuitism KW - Hyperandrogenism KW - Oligomenorrhea KW - Ovarian morphology KW - PCOS KW - Polycystic ovarian syndrome KW - Polycytic ovary SP - 1083 EP - 1090 JF - Archives of gynecology and obstetrics JO - Arch Gynecol Obstet VL - 307 IS - 4 N2 - PURPOSE: The diagnosis of polycystic ovary syndrome (PCOS) remains a challenge to clinicians due to heterogeneous clinical presentation and diagnostic criteria. This study investigated the utilization of Anti-Müllerian hormone (AMH) alone or replacing polycystic ovarian morphology (PCOM) in the PCOS diagnostic criteria. METHODS: A total of 401 women were categorised as PCOS (n:154), nonPCOS with polycystic ovarian morphology (PCOM) (n:105), and nonPCOS with normal ovarian morphology (NOM) (n:142). First, the diagnostic performance of AMH for PCOS diagnosis in Rotterdam, Androgen Excess Society, and National Institutes of Health (NIH) criteria was analyzed. Second, AMH was used instead of PCOM in Rotterdam criteria and we searched diagnostic performance for PCOS phenotypes. RESULTS: AMH levels were positively correlated with LH, testosterone, hirsutism score, menstrual cycle length, and antral follicle count (p < 0.05). AMH alone had specificity and sensitivity for PCOS diagnosis were 84.9% and 72.4% in Rotterdam (AUC: 0.866); 84.4% and 72% in Androgen Excess Society (AUC: 0.857); 83.3% and 66.4% in National Institute of Health criteria (AUC: 0.825). AMH alone had satisfactory diagnostic potential for phenotype A, but not other phenotypes. The replacement of PCOM with AMH in Rotterdam criteria had a high diagnostic potential for PCOS (AUC: 0.934, sensitivity:97.4%, specificity: 90.67%). Phenotype A and phenotype D were diagnosed with 100% sensitivity and 94.5% specificity. Phenotype C was recognised with 96.15% sensitivity and 94.5% specificity. CONCLUSION: AMH may be used with high diagnostic accuracy instead of PCOM in the Rotterdam PCOS criteria. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/36565362/The_diagnostic_performance_of_antimullerian_hormone_for_polycystic_ovarian_syndrome_and_polycystic_ovarian_morphology_ DB - PRIME DP - Unbound Medicine ER -