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Mpox diagnostics: Review of current and emerging technologies.
J Med Virol. 2023 01; 95(1):e28429.JM

Abstract

Mpox is a zoonotic disease caused by monkeypox virus (MPXV) from the Orthopoxvirus genus. Unprecedented transmission events have led to more than 70 000 cases reported worldwide by October 2022. The change in mpox epidemiology has raised concerns of its ability to establish endemicity beyond its traditional geographical locations. In this review, we discuss the current understanding of mpox virology and viral dynamics that are relevant to mpox diagnostics. A synopsis of the traditional and emerging laboratory technologies useful for MPXV detection and in guiding "elimination" strategies is outlined in this review. Importantly, development in MPXV genomics has rapidly advanced our understanding of the role of viral evolution and adaptation in the current outbreak.

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Authors+Show Affiliations

Lim CK
Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. Department of Infectious Diseases, Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
Roberts J
Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. Department of Infectious Diseases, Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
Moso M
Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. Department of Infectious Diseases, Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
Liew KC
Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. Department of Infectious Diseases, Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
Taouk ML
Department of Infectious Diseases, Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
Williams E
Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. Department of Infectious Diseases, Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
Tran T
Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. Department of Infectious Diseases, Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
Steinig E
Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. Department of Infectious Diseases, Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
Caly L
Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. Department of Infectious Diseases, Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
Williamson DA
Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. Department of Infectious Diseases, Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.

MeSH

AnimalsHumansMonkeypoxMonkeypox virusZoonosesOrthopoxvirusDisease Outbreaks

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

36571266

Citation

Lim, Chuan Kok, et al. "Mpox Diagnostics: Review of Current and Emerging Technologies." Journal of Medical Virology, vol. 95, no. 1, 2023, pp. e28429.
Lim CK, Roberts J, Moso M, et al. Mpox diagnostics: Review of current and emerging technologies. J Med Virol. 2023;95(1):e28429.
Lim, C. K., Roberts, J., Moso, M., Liew, K. C., Taouk, M. L., Williams, E., Tran, T., Steinig, E., Caly, L., & Williamson, D. A. (2023). Mpox diagnostics: Review of current and emerging technologies. Journal of Medical Virology, 95(1), e28429. https://doi.org/10.1002/jmv.28429
Lim CK, et al. Mpox Diagnostics: Review of Current and Emerging Technologies. J Med Virol. 2023;95(1):e28429. PubMed PMID: 36571266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mpox diagnostics: Review of current and emerging technologies. AU - Lim,Chuan Kok, AU - Roberts,Jason, AU - Moso,Michael, AU - Liew,Kwee Chin, AU - Taouk,Mona L, AU - Williams,Eloise, AU - Tran,Thomas, AU - Steinig,Eike, AU - Caly,Leon, AU - Williamson,Deborah Ann, PY - 2022/12/12/revised PY - 2022/11/09/received PY - 2022/12/21/accepted PY - 2022/12/27/pubmed PY - 2023/1/11/medline PY - 2022/12/26/entrez KW - diagnostics KW - genomics KW - monkeypox KW - mpox KW - orthopoxvirus KW - serology SP - e28429 EP - e28429 JF - Journal of medical virology JO - J Med Virol VL - 95 IS - 1 N2 - Mpox is a zoonotic disease caused by monkeypox virus (MPXV) from the Orthopoxvirus genus. Unprecedented transmission events have led to more than 70 000 cases reported worldwide by October 2022. The change in mpox epidemiology has raised concerns of its ability to establish endemicity beyond its traditional geographical locations. In this review, we discuss the current understanding of mpox virology and viral dynamics that are relevant to mpox diagnostics. A synopsis of the traditional and emerging laboratory technologies useful for MPXV detection and in guiding "elimination" strategies is outlined in this review. Importantly, development in MPXV genomics has rapidly advanced our understanding of the role of viral evolution and adaptation in the current outbreak. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/36571266/Mpox_diagnostics:_Review_of_current_and_emerging_technologies_ DB - PRIME DP - Unbound Medicine ER -