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Transposable elements and Alzheimer's disease pathogenesis.
Trends Neurosci. 2023 03; 46(3):170-172.TN

Abstract

Alzheimer's disease (AD) is characterized by the pathological accumulation of amyloid β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. Microglia and astrocytes respond to the abnormal presence of tau protein with induced transposable element (TE) transcription. In this Forum, we discuss new data that link dysregulated TE expression to AD pathogenesis.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Evering TH
Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.
Marston JL
Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.
Gan L
Helen and Robert Appel Alzheimer's Disease Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, 10021, USA.
Nixon DF
Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, 10021, USA. Electronic address: dnixon@med.cornell.edu.

MeSH

HumansAlzheimer DiseaseDNA Transposable ElementsAmyloid beta-Peptidestau ProteinsNeurofibrillary TanglesMicrogliaPlaque, Amyloid

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

36588011

Citation

Evering, Teresa H., et al. "Transposable Elements and Alzheimer's Disease Pathogenesis." Trends in Neurosciences, vol. 46, no. 3, 2023, pp. 170-172.
Evering TH, Marston JL, Gan L, et al. Transposable elements and Alzheimer's disease pathogenesis. Trends Neurosci. 2023;46(3):170-172.
Evering, T. H., Marston, J. L., Gan, L., & Nixon, D. F. (2023). Transposable elements and Alzheimer's disease pathogenesis. Trends in Neurosciences, 46(3), 170-172. https://doi.org/10.1016/j.tins.2022.12.003
Evering TH, et al. Transposable Elements and Alzheimer's Disease Pathogenesis. Trends Neurosci. 2023;46(3):170-172. PubMed PMID: 36588011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transposable elements and Alzheimer's disease pathogenesis. AU - Evering,Teresa H, AU - Marston,Jez L, AU - Gan,Li, AU - Nixon,Douglas F, Y1 - 2022/12/30/ PY - 2022/06/29/received PY - 2022/12/13/accepted PY - 2023/1/2/pubmed PY - 2023/2/25/medline PY - 2023/1/1/entrez KW - human endogenous retroviruses KW - innate immunity KW - long interspersed nuclear elements type 1 KW - neurodegeneration KW - retrotransposon KW - tau SP - 170 EP - 172 JF - Trends in neurosciences JO - Trends Neurosci VL - 46 IS - 3 N2 - Alzheimer's disease (AD) is characterized by the pathological accumulation of amyloid β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. Microglia and astrocytes respond to the abnormal presence of tau protein with induced transposable element (TE) transcription. In this Forum, we discuss new data that link dysregulated TE expression to AD pathogenesis. SN - 1878-108X UR - https://www.unboundmedicine.com/medline/citation/36588011/Transposable_elements_and_Alzheimer's_disease_pathogenesis_ DB - PRIME DP - Unbound Medicine ER -