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Spiking SARS-CoV-2 antiviral immunity in the respiratory tract.
Trends Immunol. 2023 02; 44(2):87-89.TI

Abstract

The COVID-19 pandemic enabled the successful launch of mRNA-based vaccines that, when given intramuscularly, elicit spike-specific antibodies and prevent severe disease, but do not promote mucosal immunity. New data suggest how to boost systemic immunity and elicit pulmonary immunity in a way that more effectively controls infection and impairs transmission.

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Authors+Show Affiliations

Silva-Sanchez A
Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Randall TD
Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: troyrandall@uabmc.edu.

MeSH

HumansSARS-CoV-2PandemicsCOVID-19Respiratory SystemAntiviral AgentsAntibodies, ViralAntibodies, Neutralizing

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

36593157

Citation

Silva-Sanchez, Aaron, and Troy D. Randall. "Spiking SARS-CoV-2 Antiviral Immunity in the Respiratory Tract." Trends in Immunology, vol. 44, no. 2, 2023, pp. 87-89.
Silva-Sanchez A, Randall TD. Spiking SARS-CoV-2 antiviral immunity in the respiratory tract. Trends Immunol. 2023;44(2):87-89.
Silva-Sanchez, A., & Randall, T. D. (2023). Spiking SARS-CoV-2 antiviral immunity in the respiratory tract. Trends in Immunology, 44(2), 87-89. https://doi.org/10.1016/j.it.2022.12.007
Silva-Sanchez A, Randall TD. Spiking SARS-CoV-2 Antiviral Immunity in the Respiratory Tract. Trends Immunol. 2023;44(2):87-89. PubMed PMID: 36593157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spiking SARS-CoV-2 antiviral immunity in the respiratory tract. AU - Silva-Sanchez,Aaron, AU - Randall,Troy D, Y1 - 2022/12/22/ PY - 2022/12/01/received PY - 2022/12/20/accepted PY - 2023/1/3/pubmed PY - 2023/2/1/medline PY - 2023/1/2/entrez SP - 87 EP - 89 JF - Trends in immunology JO - Trends Immunol VL - 44 IS - 2 N2 - The COVID-19 pandemic enabled the successful launch of mRNA-based vaccines that, when given intramuscularly, elicit spike-specific antibodies and prevent severe disease, but do not promote mucosal immunity. New data suggest how to boost systemic immunity and elicit pulmonary immunity in a way that more effectively controls infection and impairs transmission. SN - 1471-4981 UR - https://www.unboundmedicine.com/medline/citation/36593157/Spiking_SARS_CoV_2_antiviral_immunity_in_the_respiratory_tract_ DB - PRIME DP - Unbound Medicine ER -