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Effect of omega-3 fatty acid supplementation on platelet aggregability and platelet produced thromboxane.
Thromb Haemost. 1987 Jun 03; 57(3):269-72.TH

Abstract

We investigated the sustained effect of 12-week supplementation of 2.880 g/day of omega-3 fatty acids on platelet aggregability, platelet produced thromboxane B2 concentration and serum fatty acid composition in a double-blind controlled trial in 44 healthy mildly overweight eastern Finnish men recruited from a representative population sample. The supplementation was discontinued seven days before the biochemical measurements. Body weight, alcohol consumption and dietary composition remained constant during the study. Even though the percentage of eicosapentaenoic acid (20:5 omega 3) in total serum lipids increased by 37% (p less than 0.01) and that of dihomo-gamma-linolenic acid (20:3 omega 6) decreased by 18% (p less than 0.01) more in the omega-3 supplemented than placebo group during supplementation, there were no significant differences in the changes in either the ADP induced platelet aggregation or in vitro platelet produced thromboxane B2 concentration between the groups. These data suggest that omega-3 fatty acids have no detectable sustained effect either on ADP induced platelet aggregation or on thromboxane produced by the platelets in vitro.

Authors+Show Affiliations

Kuopio Research Institute of Exercise Medicine, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3660329

Citation

Salonen, R, et al. "Effect of Omega-3 Fatty Acid Supplementation On Platelet Aggregability and Platelet Produced Thromboxane." Thrombosis and Haemostasis, vol. 57, no. 3, 1987, pp. 269-72.
Salonen R, Nikkari T, Seppänen K, et al. Effect of omega-3 fatty acid supplementation on platelet aggregability and platelet produced thromboxane. Thromb Haemost. 1987;57(3):269-72.
Salonen, R., Nikkari, T., Seppänen, K., Venäläinen, J. M., Ihanainen, M., Rissanen, V., Rauramaa, R., & Salonen, J. T. (1987). Effect of omega-3 fatty acid supplementation on platelet aggregability and platelet produced thromboxane. Thrombosis and Haemostasis, 57(3), 269-72.
Salonen R, et al. Effect of Omega-3 Fatty Acid Supplementation On Platelet Aggregability and Platelet Produced Thromboxane. Thromb Haemost. 1987 Jun 3;57(3):269-72. PubMed PMID: 3660329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of omega-3 fatty acid supplementation on platelet aggregability and platelet produced thromboxane. AU - Salonen,R, AU - Nikkari,T, AU - Seppänen,K, AU - Venäläinen,J M, AU - Ihanainen,M, AU - Rissanen,V, AU - Rauramaa,R, AU - Salonen,J T, PY - 1987/6/3/pubmed PY - 1987/6/3/medline PY - 1987/6/3/entrez SP - 269 EP - 72 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 57 IS - 3 N2 - We investigated the sustained effect of 12-week supplementation of 2.880 g/day of omega-3 fatty acids on platelet aggregability, platelet produced thromboxane B2 concentration and serum fatty acid composition in a double-blind controlled trial in 44 healthy mildly overweight eastern Finnish men recruited from a representative population sample. The supplementation was discontinued seven days before the biochemical measurements. Body weight, alcohol consumption and dietary composition remained constant during the study. Even though the percentage of eicosapentaenoic acid (20:5 omega 3) in total serum lipids increased by 37% (p less than 0.01) and that of dihomo-gamma-linolenic acid (20:3 omega 6) decreased by 18% (p less than 0.01) more in the omega-3 supplemented than placebo group during supplementation, there were no significant differences in the changes in either the ADP induced platelet aggregation or in vitro platelet produced thromboxane B2 concentration between the groups. These data suggest that omega-3 fatty acids have no detectable sustained effect either on ADP induced platelet aggregation or on thromboxane produced by the platelets in vitro. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/3660329/Effect_of_omega_3_fatty_acid_supplementation_on_platelet_aggregability_and_platelet_produced_thromboxane_ DB - PRIME DP - Unbound Medicine ER -