Tags

Type your tag names separated by a space and hit enter

Role and Dysregulation of miRNA in Patients with Parkinson's Disease.
Int J Mol Sci. 2022 Dec 31; 24(1)IJ

Abstract

Parkinson's disease (PD) is a neurodegenerative synucleinopathy that has a not yet fully understood molecular pathomechanism behind it. The role of risk genes regulated by small non-coding RNAs, or microRNAs (miRNAs), has also been highlighted in PD, where they may influence disease progression and comorbidities. In this case-control study, we analyzed miRNAs on peripheral blood mononuclear cells by means of RNA-seq in 30 participants, with the aim of identifying miRNAs differentially expressed in PD compared to age-matched healthy controls. Additionally, we investigated the pathways influenced by differentially expressed miRNAs and assessed whether a specific pathway could potentially be associated with PD susceptibility (enrichment analyses performed using the Ingenuity Pathway Analysis tools). Overall, considering that the upregulation of miRNAs might be related with the downregulation of their messenger RNA targets, and vice versa, we found several putative targets of dysregulated miRNAs (i.e., upregulated: hsa-miR-1275, hsa-miR-23a-5p, hsa-miR-432-5p, hsa-miR-4433b-3p, and hsa-miR-4443; downregulated: hsa-miR-142-5p, hsa-miR-143-3p, hsa-miR-374a-3p, hsa-miR-542-3p, and hsa-miR-99a-5p). An inverse connection between cancer and neurodegeneration, called "inverse comorbidity", has also been noted, showing that some genes or miRNAs may be expressed oppositely in neurodegenerative disorders and in some cancers. Therefore, it may be reasonable to consider these miRNAs as potential diagnostic markers and outcome measures.

Links

PMC Free PDF

Authors+Show Affiliations

Salemi M
Oasi Research Institute-IRCCS, 94018 Troina, Italy.
Marchese G
Genomix4Life Srl, 84081 Baronissi, Italy. Genome Research Center for Health-CRGS, 84081 Baronissi, Italy.
Lanza G
Oasi Research Institute-IRCCS, 94018 Troina, Italy. Department of Surgery and Medical-Surgical Specialties, University of Catania, 95123 Catania, Italy.
Cosentino FII
Oasi Research Institute-IRCCS, 94018 Troina, Italy.
Salluzzo MG
Oasi Research Institute-IRCCS, 94018 Troina, Italy.
Schillaci FA
Oasi Research Institute-IRCCS, 94018 Troina, Italy.
Ventola GM
Genomix4Life Srl, 84081 Baronissi, Italy. Genome Research Center for Health-CRGS, 84081 Baronissi, Italy.
Cordella A
Genomix4Life Srl, 84081 Baronissi, Italy. Genome Research Center for Health-CRGS, 84081 Baronissi, Italy.
Ravo M
Genomix4Life Srl, 84081 Baronissi, Italy. Genome Research Center for Health-CRGS, 84081 Baronissi, Italy.
Ferri R
Oasi Research Institute-IRCCS, 94018 Troina, Italy.

MeSH

HumansParkinson DiseaseCase-Control StudiesLeukocytes, MononuclearMicroRNAsDown-Regulation

Pub Type(s)

Journal Article

Language

eng

PubMed ID

36614153

Citation

Salemi, Michele, et al. "Role and Dysregulation of miRNA in Patients With Parkinson's Disease." International Journal of Molecular Sciences, vol. 24, no. 1, 2022.
Salemi M, Marchese G, Lanza G, et al. Role and Dysregulation of miRNA in Patients with Parkinson's Disease. Int J Mol Sci. 2022;24(1).
Salemi, M., Marchese, G., Lanza, G., Cosentino, F. I. I., Salluzzo, M. G., Schillaci, F. A., Ventola, G. M., Cordella, A., Ravo, M., & Ferri, R. (2022). Role and Dysregulation of miRNA in Patients with Parkinson's Disease. International Journal of Molecular Sciences, 24(1). https://doi.org/10.3390/ijms24010712
Salemi M, et al. Role and Dysregulation of miRNA in Patients With Parkinson's Disease. Int J Mol Sci. 2022 Dec 31;24(1) PubMed PMID: 36614153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role and Dysregulation of miRNA in Patients with Parkinson's Disease. AU - Salemi,Michele, AU - Marchese,Giovanna, AU - Lanza,Giuseppe, AU - Cosentino,Filomena I I, AU - Salluzzo,Maria Grazia, AU - Schillaci,Francesca A, AU - Ventola,Giovanna Maria, AU - Cordella,Angela, AU - Ravo,Maria, AU - Ferri,Raffaele, Y1 - 2022/12/31/ PY - 2022/11/17/received PY - 2022/12/20/revised PY - 2022/12/27/accepted PY - 2023/1/8/entrez PY - 2023/1/9/pubmed PY - 2023/1/11/medline KW - Parkinson’s disease KW - ingenuity pathway analysis KW - miRNA KW - miRNA sequencing KW - microRNA KW - synucleinopathy JF - International journal of molecular sciences JO - Int J Mol Sci VL - 24 IS - 1 N2 - Parkinson's disease (PD) is a neurodegenerative synucleinopathy that has a not yet fully understood molecular pathomechanism behind it. The role of risk genes regulated by small non-coding RNAs, or microRNAs (miRNAs), has also been highlighted in PD, where they may influence disease progression and comorbidities. In this case-control study, we analyzed miRNAs on peripheral blood mononuclear cells by means of RNA-seq in 30 participants, with the aim of identifying miRNAs differentially expressed in PD compared to age-matched healthy controls. Additionally, we investigated the pathways influenced by differentially expressed miRNAs and assessed whether a specific pathway could potentially be associated with PD susceptibility (enrichment analyses performed using the Ingenuity Pathway Analysis tools). Overall, considering that the upregulation of miRNAs might be related with the downregulation of their messenger RNA targets, and vice versa, we found several putative targets of dysregulated miRNAs (i.e., upregulated: hsa-miR-1275, hsa-miR-23a-5p, hsa-miR-432-5p, hsa-miR-4433b-3p, and hsa-miR-4443; downregulated: hsa-miR-142-5p, hsa-miR-143-3p, hsa-miR-374a-3p, hsa-miR-542-3p, and hsa-miR-99a-5p). An inverse connection between cancer and neurodegeneration, called "inverse comorbidity", has also been noted, showing that some genes or miRNAs may be expressed oppositely in neurodegenerative disorders and in some cancers. Therefore, it may be reasonable to consider these miRNAs as potential diagnostic markers and outcome measures. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/36614153/Role_and_Dysregulation_of_miRNA_in_Patients_with_Parkinson's_Disease_ DB - PRIME DP - Unbound Medicine ER -