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Comparison of technetium-99m sulfur colloid and technetium-99m albumin colloid labeled solid meals for gastric emptying studies.
Clin Nucl Med. 1987 Aug; 12(8):597-600.CN

Abstract

A Tc-99m albumin colloid (Tc-AC) kit has been introduced as an alternative to Tc-99m sulfur colloid (Tc-SC) for liver-spleen imaging. Since there is no need for boiling, the use of Tc-AC reduces preparation time and manipulation. Tc-SC is one of the most commonly used radiopharmaceuticals for the labeling of solid-phase markers in gastric emptying studies. In vitro studies were performed to evaluate the labeling efficiency and stability in hydrochloric acid and in human gastric juice of intracellularly labeled chicken liver and scrambled eggs labeled with Tc-SC and Tc-AC. Gastric emptying studies also were performed on 20 healthy volunteers with both Tc-SC and Tc-AC labeled scrambled egg sandwiches. There was no significant difference between Tc-SC and Tc-AC in the labeling efficiency of chicken liver (98% +/- 1% for Tc-SC, 96% +/- 2% for Tc-AC) and scrambled eggs (92% +/- 2% for Tc-SC, 91% +/- 3% for Tc-AC). However, both Tc-SC and Tc-AC labeled scrambled eggs showed a lower stability than chicken liver, particularly in human gastric juice. Gastric emptying curves from both meals in 20 normal subjects were also similar, with a mean half-emptying time of 85 +/- 13 minutes and 87 +/- 16 minutes for the meals containing Tc-SC and Tc-AC respectively. Tc-AC is a reliable alternative to Tc-SC as a radiotracer for solid-phase gastric emptying studies.

Authors+Show Affiliations

Department of Nuclear Medicine, Hôpital Hôtel-Dieu de Montréal, Québec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3665298

Citation

Taillefer, R, et al. "Comparison of Technetium-99m Sulfur Colloid and Technetium-99m Albumin Colloid Labeled Solid Meals for Gastric Emptying Studies." Clinical Nuclear Medicine, vol. 12, no. 8, 1987, pp. 597-600.
Taillefer R, Douesnard JM, Beauchamp G, et al. Comparison of technetium-99m sulfur colloid and technetium-99m albumin colloid labeled solid meals for gastric emptying studies. Clin Nucl Med. 1987;12(8):597-600.
Taillefer, R., Douesnard, J. M., Beauchamp, G., & Guimond, J. (1987). Comparison of technetium-99m sulfur colloid and technetium-99m albumin colloid labeled solid meals for gastric emptying studies. Clinical Nuclear Medicine, 12(8), 597-600.
Taillefer R, et al. Comparison of Technetium-99m Sulfur Colloid and Technetium-99m Albumin Colloid Labeled Solid Meals for Gastric Emptying Studies. Clin Nucl Med. 1987;12(8):597-600. PubMed PMID: 3665298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of technetium-99m sulfur colloid and technetium-99m albumin colloid labeled solid meals for gastric emptying studies. AU - Taillefer,R, AU - Douesnard,J M, AU - Beauchamp,G, AU - Guimond,J, PY - 1987/8/1/pubmed PY - 1987/8/1/medline PY - 1987/8/1/entrez SP - 597 EP - 600 JF - Clinical nuclear medicine JO - Clin Nucl Med VL - 12 IS - 8 N2 - A Tc-99m albumin colloid (Tc-AC) kit has been introduced as an alternative to Tc-99m sulfur colloid (Tc-SC) for liver-spleen imaging. Since there is no need for boiling, the use of Tc-AC reduces preparation time and manipulation. Tc-SC is one of the most commonly used radiopharmaceuticals for the labeling of solid-phase markers in gastric emptying studies. In vitro studies were performed to evaluate the labeling efficiency and stability in hydrochloric acid and in human gastric juice of intracellularly labeled chicken liver and scrambled eggs labeled with Tc-SC and Tc-AC. Gastric emptying studies also were performed on 20 healthy volunteers with both Tc-SC and Tc-AC labeled scrambled egg sandwiches. There was no significant difference between Tc-SC and Tc-AC in the labeling efficiency of chicken liver (98% +/- 1% for Tc-SC, 96% +/- 2% for Tc-AC) and scrambled eggs (92% +/- 2% for Tc-SC, 91% +/- 3% for Tc-AC). However, both Tc-SC and Tc-AC labeled scrambled eggs showed a lower stability than chicken liver, particularly in human gastric juice. Gastric emptying curves from both meals in 20 normal subjects were also similar, with a mean half-emptying time of 85 +/- 13 minutes and 87 +/- 16 minutes for the meals containing Tc-SC and Tc-AC respectively. Tc-AC is a reliable alternative to Tc-SC as a radiotracer for solid-phase gastric emptying studies. SN - 0363-9762 UR - https://www.unboundmedicine.com/medline/citation/3665298/Comparison_of_technetium_99m_sulfur_colloid_and_technetium_99m_albumin_colloid_labeled_solid_meals_for_gastric_emptying_studies_ DB - PRIME DP - Unbound Medicine ER -