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Pre-natal dietary imbalance of folic acid and vitamin B12 deficiency adversely impacts placental development and fetal growth.
Placenta. 2023 02; 132:44-54.P

Abstract

INTRODUCTION

The common practice of supplementing folic acid during pregnancy and the absence of such guidelines for vitamin B12 lead to an imbalance of these vitamins, especially in developing countries like India, where many women are vitamin B12 deficient.

METHODS

The present study was designed to explore the effect of low vitamin B12 in combination with different levels of folic acid in the parental diet on fetal growth parameters and maternal reproductive performance in a transgenerational manner. The reversibility of these effects was studied by shifting the mice to a regular diet in the F1 generation in the case of transient groups and continued on the same diet in the sustained groups after the dietary exposure in the F0 generation.

RESULTS

Vitamin B12 deficiency and different levels of folic acid resulted in the decreased placental and fetal weight of the F1 generation. Surprisingly, a decreased placental weight, low fetal weight, and reduced crown-rump length and head circumference were observed in F2 fetuses of vitamin B12 deficient with folate over-supplemented (BDFO) transient group, i.e. when F1 mice were shifted to normal diet conditions. Reduced follicles in ovaries and alteration in placental pathology in all the F0 groups and BDFO of the F1 transient group were also seen.

DISCUSSION

Overall, the study revealed that dietary imbalance of vitamin B12 and folic acid, particularly B12 deficiency with over-supplemented folic acid, negatively affects placental and fetal development and maternal reproductive performance. Such effects are passed on to the next generation too.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Sapehia D
Department of Biochemistry, PGIMER, Chandigarh, India. Electronic address: divika90@gmail.com.
Mahajan A
Department of Biochemistry, PGIMER, Chandigarh, India. Electronic address: aatish.mahajan@gmail.com.
Srinivasan R
Department Cytology & Gynaecological Pathology, PGIMER, Chandigarh, India. Electronic address: radhika.s@pgimer.edu.in.
Kaur J
Department of Biochemistry, PGIMER, Chandigarh, India. Electronic address: kaur.jyotdeep@pgimer.edu.in.

MeSH

FemalePregnancyMiceAnimalsFolic AcidPlacentationFetal WeightPlacentaVitamin B 12 DeficiencyVitamin B 12DietFetal DevelopmentHomocysteine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

36657272

Citation

Sapehia, Divika, et al. "Pre-natal Dietary Imbalance of Folic Acid and Vitamin B12 Deficiency Adversely Impacts Placental Development and Fetal Growth." Placenta, vol. 132, 2023, pp. 44-54.
Sapehia D, Mahajan A, Srinivasan R, et al. Pre-natal dietary imbalance of folic acid and vitamin B12 deficiency adversely impacts placental development and fetal growth. Placenta. 2023;132:44-54.
Sapehia, D., Mahajan, A., Srinivasan, R., & Kaur, J. (2023). Pre-natal dietary imbalance of folic acid and vitamin B12 deficiency adversely impacts placental development and fetal growth. Placenta, 132, 44-54. https://doi.org/10.1016/j.placenta.2023.01.003
Sapehia D, et al. Pre-natal Dietary Imbalance of Folic Acid and Vitamin B12 Deficiency Adversely Impacts Placental Development and Fetal Growth. Placenta. 2023;132:44-54. PubMed PMID: 36657272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre-natal dietary imbalance of folic acid and vitamin B12 deficiency adversely impacts placental development and fetal growth. AU - Sapehia,Divika, AU - Mahajan,Aatish, AU - Srinivasan,Radhika, AU - Kaur,Jyotdeep, Y1 - 2023/01/03/ PY - 2022/09/22/received PY - 2022/12/15/revised PY - 2023/01/02/accepted PY - 2023/1/20/pubmed PY - 2023/2/7/medline PY - 2023/1/19/entrez KW - Corpus luteum KW - Fetal growth parameters KW - Folic acid KW - Homocysteine KW - Placenta KW - Vitamin B12 SP - 44 EP - 54 JF - Placenta JO - Placenta VL - 132 N2 - INTRODUCTION: The common practice of supplementing folic acid during pregnancy and the absence of such guidelines for vitamin B12 lead to an imbalance of these vitamins, especially in developing countries like India, where many women are vitamin B12 deficient. METHODS: The present study was designed to explore the effect of low vitamin B12 in combination with different levels of folic acid in the parental diet on fetal growth parameters and maternal reproductive performance in a transgenerational manner. The reversibility of these effects was studied by shifting the mice to a regular diet in the F1 generation in the case of transient groups and continued on the same diet in the sustained groups after the dietary exposure in the F0 generation. RESULTS: Vitamin B12 deficiency and different levels of folic acid resulted in the decreased placental and fetal weight of the F1 generation. Surprisingly, a decreased placental weight, low fetal weight, and reduced crown-rump length and head circumference were observed in F2 fetuses of vitamin B12 deficient with folate over-supplemented (BDFO) transient group, i.e. when F1 mice were shifted to normal diet conditions. Reduced follicles in ovaries and alteration in placental pathology in all the F0 groups and BDFO of the F1 transient group were also seen. DISCUSSION: Overall, the study revealed that dietary imbalance of vitamin B12 and folic acid, particularly B12 deficiency with over-supplemented folic acid, negatively affects placental and fetal development and maternal reproductive performance. Such effects are passed on to the next generation too. SN - 1532-3102 UR - https://www.unboundmedicine.com/medline/citation/36657272/Pre_natal_dietary_imbalance_of_folic_acid_and_vitamin_B12_deficiency_adversely_impacts_placental_development_and_fetal_growth_ DB - PRIME DP - Unbound Medicine ER -