Abstract
BACKGROUND
The angiotensin-renin system (ARS) has been shown to play a role in the promotion of tissue fibrosis through angiotensin II activation of the angiotensin-receptor 1 and subsequently transforming growth factor beta-1 (TGF- β1). Breast reduction surgery is known to have a potential complication of hypertrophic scarring. The primary objective of this study is to assess whether the use of angiotensin-converting enzyme inhibitor (ACEi) or angiotensin II receptor blockers (ARBs) by patients undergoing bilateral reduction mammoplasty is correlated with a reduction in hypertrophic scarring complications post-operatively.
METHODS
A retrospective chart review of all patients who received bilateral breast reduction surgery in our province over a 10-year period was performed. Patient charts were reviewed for post-operative hypertrophic scarring as well as medications being used around the time of surgery. The rate of hypertrophic scarring within patients treated with an ACEi or ARB for existing hypertension were compared with the rest of the population.
RESULTS
A total of 981 patients met the inclusion criteria of the study. The overall incidence of hypertrophic scarring was 6%. Within the population, 132 (14%) of patients had a clinical diagnosis of hypertension. Of the patients who were managed with an ACEi or ARB, one (2%) patient developed hypertrophic scarring post-operatively. This was significantly less than the total population and the remainder of the population with hypertension treated with a medication other than an ACEi or ARB.
CONCLUSIONS
This study investigated the impact of routine ACEi or ARB use by patients undergoing bilateral reduction mammoplasty and demonstrated a statistically significant reduction in the incidence of hypertrophic scarring. This study is one of the first to investigate ACEi or ARB use in humans to reduce rates of unsightly scarring.
LEVEL OF EVIDENCE
Level III.
TY - JOUR
T1 - The Role of ACE-Inhibitors and ARBs in reducing hypertrophic scarring following bilateral breast reduction.
AU - Dow,Todd,
AU - Selman,Tamara,
AU - Williams,Jason,
AU - Bezuhly,Michael,
Y1 - 2023/01/12/
PY - 2022/07/05/received
PY - 2022/08/20/revised
PY - 2022/11/17/accepted
PY - 2023/3/28/medline
PY - 2023/1/21/pubmed
PY - 2023/1/20/entrez
KW - Angiotensin II receptor antagonist
KW - Angiotensin converting enzyme inhibitors
KW - Angiotensin-renin system
KW - Breast reduction
KW - Hypertrophic scarring
SP - 1
EP - 3
JF - Journal of plastic, reconstructive & aesthetic surgery : JPRAS
JO - J Plast Reconstr Aesthet Surg
VL - 78
N2 - BACKGROUND: The angiotensin-renin system (ARS) has been shown to play a role in the promotion of tissue fibrosis through angiotensin II activation of the angiotensin-receptor 1 and subsequently transforming growth factor beta-1 (TGF- β1). Breast reduction surgery is known to have a potential complication of hypertrophic scarring. The primary objective of this study is to assess whether the use of angiotensin-converting enzyme inhibitor (ACEi) or angiotensin II receptor blockers (ARBs) by patients undergoing bilateral reduction mammoplasty is correlated with a reduction in hypertrophic scarring complications post-operatively. METHODS: A retrospective chart review of all patients who received bilateral breast reduction surgery in our province over a 10-year period was performed. Patient charts were reviewed for post-operative hypertrophic scarring as well as medications being used around the time of surgery. The rate of hypertrophic scarring within patients treated with an ACEi or ARB for existing hypertension were compared with the rest of the population. RESULTS: A total of 981 patients met the inclusion criteria of the study. The overall incidence of hypertrophic scarring was 6%. Within the population, 132 (14%) of patients had a clinical diagnosis of hypertension. Of the patients who were managed with an ACEi or ARB, one (2%) patient developed hypertrophic scarring post-operatively. This was significantly less than the total population and the remainder of the population with hypertension treated with a medication other than an ACEi or ARB. CONCLUSIONS: This study investigated the impact of routine ACEi or ARB use by patients undergoing bilateral reduction mammoplasty and demonstrated a statistically significant reduction in the incidence of hypertrophic scarring. This study is one of the first to investigate ACEi or ARB use in humans to reduce rates of unsightly scarring. LEVEL OF EVIDENCE: Level III.
SN - 1878-0539
UR - https://www.unboundmedicine.com/medline/citation/36669236/The_Role_of_ACE_Inhibitors_and_ARBs_in_reducing_hypertrophic_scarring_following_bilateral_breast_reduction_
DB - PRIME
DP - Unbound Medicine
ER -
