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Single-unit analysis of postnatal olfactory learning: modified olfactory bulb output response patterns to learned attractive odors.
J Neurosci. 1987 Oct; 7(10):3154-62.JN

Abstract

Neonatal rats learn to approach odors associated with stimulation normally provided by their mother. The present report describes changes in olfactory bulb single-unit activity following olfactory learning in young rats. Rat pups were exposed from postnatal day 1 to 18 to either (1) peppermint-scented air while receiving tactile stimulation (Pepp-Stroked), (2) peppermint-scented air with no tactile stimulation (Pepp-Only), (3) clean air and tactile stimulation (Stroked-Only), or (4) clean air and no tactile stimulation (Naive). On day 19, single-unit activity was recorded from mitral/tufted cells in urethane-anesthetized, freely breathing pups in response to either peppermint or a novel orange odor. Mitral/tufted cell response patterns to peppermint were significantly altered in Pepp-Stroked animals compared to control pups. Peppermint exposure alone, not associated with tactile stimulation (Pepp-Only), did not affect subsequent single-cell response patterns to that odor. In addition, the modification of response patterns was specific to peppermint and was not associated with a change in respiration rate. Furthermore, Pepp-Stroked pups had a relative behavioral preference for peppermint on day 19 compared to control pups. These results demonstrate that postnatal olfactory learning selectively modifies the subsequent response patterns of olfactory bulb output cells to the attractive odor. Furthermore, these results indicate that the initial coding of an odor's attractive value occurs within the olfactory bulb.

Authors+Show Affiliations

Department of Psychobiology, University of California, Irvine 92717.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3668621

Citation

Wilson, D A., et al. "Single-unit Analysis of Postnatal Olfactory Learning: Modified Olfactory Bulb Output Response Patterns to Learned Attractive Odors." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, vol. 7, no. 10, 1987, pp. 3154-62.
Wilson DA, Sullivan RM, Leon M. Single-unit analysis of postnatal olfactory learning: modified olfactory bulb output response patterns to learned attractive odors. J Neurosci. 1987;7(10):3154-62.
Wilson, D. A., Sullivan, R. M., & Leon, M. (1987). Single-unit analysis of postnatal olfactory learning: modified olfactory bulb output response patterns to learned attractive odors. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 7(10), 3154-62.
Wilson DA, Sullivan RM, Leon M. Single-unit Analysis of Postnatal Olfactory Learning: Modified Olfactory Bulb Output Response Patterns to Learned Attractive Odors. J Neurosci. 1987;7(10):3154-62. PubMed PMID: 3668621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Single-unit analysis of postnatal olfactory learning: modified olfactory bulb output response patterns to learned attractive odors. AU - Wilson,D A, AU - Sullivan,R M, AU - Leon,M, PY - 1987/10/1/pubmed PY - 1987/10/1/medline PY - 1987/10/1/entrez SP - 3154 EP - 62 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience JO - J Neurosci VL - 7 IS - 10 N2 - Neonatal rats learn to approach odors associated with stimulation normally provided by their mother. The present report describes changes in olfactory bulb single-unit activity following olfactory learning in young rats. Rat pups were exposed from postnatal day 1 to 18 to either (1) peppermint-scented air while receiving tactile stimulation (Pepp-Stroked), (2) peppermint-scented air with no tactile stimulation (Pepp-Only), (3) clean air and tactile stimulation (Stroked-Only), or (4) clean air and no tactile stimulation (Naive). On day 19, single-unit activity was recorded from mitral/tufted cells in urethane-anesthetized, freely breathing pups in response to either peppermint or a novel orange odor. Mitral/tufted cell response patterns to peppermint were significantly altered in Pepp-Stroked animals compared to control pups. Peppermint exposure alone, not associated with tactile stimulation (Pepp-Only), did not affect subsequent single-cell response patterns to that odor. In addition, the modification of response patterns was specific to peppermint and was not associated with a change in respiration rate. Furthermore, Pepp-Stroked pups had a relative behavioral preference for peppermint on day 19 compared to control pups. These results demonstrate that postnatal olfactory learning selectively modifies the subsequent response patterns of olfactory bulb output cells to the attractive odor. Furthermore, these results indicate that the initial coding of an odor's attractive value occurs within the olfactory bulb. SN - 0270-6474 UR - https://www.unboundmedicine.com/medline/citation/3668621/Single_unit_analysis_of_postnatal_olfactory_learning:_modified_olfactory_bulb_output_response_patterns_to_learned_attractive_odors_ L2 - http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=3668621 DB - PRIME DP - Unbound Medicine ER -