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Off-label treatments as potential accelerators in the search for the ideal antifungal treatment of cryptococcosis.
Future Microbiol. 2023 01; 18:127-135.FM

Abstract

Cryptococcosis is an opportunistic mycosis that mainly affects immunosuppressed patients. The treatment is a combination of three antifungal agents: amphotericin B, 5-flucytosine and fluconazole. However, these drugs have many disadvantages, such as high nephrotoxicity, marketing bans in some countries and fungal resistance. One of the solutions to find possible new drugs is pharmacological repositioning. This work presents repositioned drugs as an alternative for new antifungal therapies for cryptococcosis. All the studies here were performed in vitro or in animal models, except for sertraline, which reached phase III in humans. There is still no pharmacological repositioning approval for cryptococcosis in humans, though this review shows the potential of repurposing as a rapid approach to finding new agents to treat cryptococcosis.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Alves V
Laboratório de Biofísica de Fungos, Instituto de Biofísica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, 21941902, Brazil.
Araújo GR
Laboratório de Biofísica de Fungos, Instituto de Biofísica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, 21941902, Brazil.
Frases S
Laboratório de Biofísica de Fungos, Instituto de Biofísica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, 21941902, Brazil.

MeSH

AnimalsHumansAntifungal AgentsOff-Label UseFluconazoleCryptococcosisAmphotericin BCryptococcus neoformans

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

36688321

Citation

Alves, Vinicius, et al. "Off-label Treatments as Potential Accelerators in the Search for the Ideal Antifungal Treatment of Cryptococcosis." Future Microbiology, vol. 18, 2023, pp. 127-135.
Alves V, Araújo GR, Frases S. Off-label treatments as potential accelerators in the search for the ideal antifungal treatment of cryptococcosis. Future Microbiol. 2023;18:127-135.
Alves, V., Araújo, G. R., & Frases, S. (2023). Off-label treatments as potential accelerators in the search for the ideal antifungal treatment of cryptococcosis. Future Microbiology, 18, 127-135. https://doi.org/10.2217/fmb-2022-0122
Alves V, Araújo GR, Frases S. Off-label Treatments as Potential Accelerators in the Search for the Ideal Antifungal Treatment of Cryptococcosis. Future Microbiol. 2023;18:127-135. PubMed PMID: 36688321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Off-label treatments as potential accelerators in the search for the ideal antifungal treatment of cryptococcosis. AU - Alves,Vinicius, AU - Araújo,Glauber Rs, AU - Frases,Susana, Y1 - 2023/01/23/ PY - 2023/1/24/pubmed PY - 2023/3/7/medline PY - 2023/1/23/entrez KW - Cryptococcus KW - antifungal KW - cryptococcosis KW - off-label medication KW - repositioning drugs SP - 127 EP - 135 JF - Future microbiology JO - Future Microbiol VL - 18 N2 - Cryptococcosis is an opportunistic mycosis that mainly affects immunosuppressed patients. The treatment is a combination of three antifungal agents: amphotericin B, 5-flucytosine and fluconazole. However, these drugs have many disadvantages, such as high nephrotoxicity, marketing bans in some countries and fungal resistance. One of the solutions to find possible new drugs is pharmacological repositioning. This work presents repositioned drugs as an alternative for new antifungal therapies for cryptococcosis. All the studies here were performed in vitro or in animal models, except for sertraline, which reached phase III in humans. There is still no pharmacological repositioning approval for cryptococcosis in humans, though this review shows the potential of repurposing as a rapid approach to finding new agents to treat cryptococcosis. SN - 1746-0921 UR - https://www.unboundmedicine.com/medline/citation/36688321/Off-label_treatments_as_potential_accelerators_in_the_search_for_the_ideal_antifungal_treatment_of_cryptococcosis. DB - PRIME DP - Unbound Medicine ER -

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