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Reproducibility of cold provocation in patients with Raynaud's phenomenon.
J Rheumatol. 1987 Aug; 14(4):751-5.JR

Abstract

Twenty-five patients with Raynaud's phenomenon had serial cold challenges during a double blinded drug trial. The data were analyzed to determine the reproducibility of cold provocation in the induction of critical closure of the digital artery in patients with Raynaud's phenomenon. Finger systolic pressure (FSP) was measured after local digital cooling using a digital strain gauge placed around the distal phalanx. Nineteen of 25 patients completed the study. The prevalence of inducing a Raynaud's attack decreased with each successive cold challenge from 74% of patients at initial challenge to 42% at the 3rd challenge. A lower temperature was required to induce a Raynaud's attack at last challenge (10.6 +/- 0.6 degrees C) compared to the first cold challenge (13.2 +/- 1.0 degrees C). Our data demonstrate adaptation to a laboratory cold challenge through the winter months in patients with Raynaud's phenomenon and show it is an important factor in objectively assessing drug efficacy in the treatment of Raynaud's phenomenon.

Authors+Show Affiliations

Department of Medicine, Johns Hopkins Medical Institutions, Francis Scott Key Medical Center, Baltimore, MD 21224.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3668980

Citation

Wigley, F M., et al. "Reproducibility of Cold Provocation in Patients With Raynaud's Phenomenon." The Journal of Rheumatology, vol. 14, no. 4, 1987, pp. 751-5.
Wigley FM, Malamet R, Wise RA. Reproducibility of cold provocation in patients with Raynaud's phenomenon. J Rheumatol. 1987;14(4):751-5.
Wigley, F. M., Malamet, R., & Wise, R. A. (1987). Reproducibility of cold provocation in patients with Raynaud's phenomenon. The Journal of Rheumatology, 14(4), 751-5.
Wigley FM, Malamet R, Wise RA. Reproducibility of Cold Provocation in Patients With Raynaud's Phenomenon. J Rheumatol. 1987;14(4):751-5. PubMed PMID: 3668980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reproducibility of cold provocation in patients with Raynaud's phenomenon. AU - Wigley,F M, AU - Malamet,R, AU - Wise,R A, PY - 1987/8/1/pubmed PY - 1987/8/1/medline PY - 1987/8/1/entrez SP - 751 EP - 5 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 14 IS - 4 N2 - Twenty-five patients with Raynaud's phenomenon had serial cold challenges during a double blinded drug trial. The data were analyzed to determine the reproducibility of cold provocation in the induction of critical closure of the digital artery in patients with Raynaud's phenomenon. Finger systolic pressure (FSP) was measured after local digital cooling using a digital strain gauge placed around the distal phalanx. Nineteen of 25 patients completed the study. The prevalence of inducing a Raynaud's attack decreased with each successive cold challenge from 74% of patients at initial challenge to 42% at the 3rd challenge. A lower temperature was required to induce a Raynaud's attack at last challenge (10.6 +/- 0.6 degrees C) compared to the first cold challenge (13.2 +/- 1.0 degrees C). Our data demonstrate adaptation to a laboratory cold challenge through the winter months in patients with Raynaud's phenomenon and show it is an important factor in objectively assessing drug efficacy in the treatment of Raynaud's phenomenon. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/3668980/Reproducibility_of_cold_provocation_in_patients_with_Raynaud's_phenomenon_ L2 - https://medlineplus.gov/scleroderma.html DB - PRIME DP - Unbound Medicine ER -