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Mediterranean diet is associated with a lower probability of prodromal Parkinson's disease and risk for Parkinson's disease/dementia with Lewy bodies: A longitudinal study.
Eur J Neurol. 2023 04; 30(4):934-942.EJ

Abstract

BACKGROUND AND PURPOSE

Lifestyle factors have been implicated in the long-lasting neurodegenerative process in prodromal Parkinson's disease (pPD). The aim was to investigate the associations between adherence to a Mediterranean diet (MeDi) and longitudinal changes of pPD probability and the development of Parkinson's disease (PD) or pPD in a Mediterranean older population.

METHODS

Data from the Hellenic Longitudinal Investigation of Aging and Diet cohort (community-dwelling individuals, aged ≥ 65 years) were used. A detailed food frequency questionnaire was used to evaluate dietary intake and calculate MeDi adherence score, ranging from 0 to 55, with higher scores indicating higher adherence. The probability of pPD was calculated according to the updated Movement Disorder Society research criteria.

RESULTS

In all, 1047 non-PD/dementia with Lewy bodies (DLB) participants were followed for 3 ± 1 years. MeDi adherence was associated with lower increase in pPD probability over time (b = -0.003, 95% confidence interval -0.006 to -0.001, p = 0.010). Forty-nine participants had incident possible/probable pPD (i.e., pPD probability ≥ 30%). Compared to the participants in the lowest quartile of MeDi adherence, those in the higher quartiles had an approximately 60%-70% lower risk for possible/probable pPD (p for trend 0.003). MeDi-pPD associations were driven by both motor and non-motor pPD markers and not from risk markers. Also, 21 participants were diagnosed with PD/DLB at follow-up. For each unit increase in the MeDi score, there was a 9%-10% lower risk for PD/DLB (hazard ratio 0.906 [95% confidence interval 0.823-0.997], p = 0.044).

CONCLUSIONS

Mediterranean diet adherence is associated with lower increase in pPD probability over time and lower possible/probable pPD and PD/DLB incidence in older Mediterranean people. More studies are needed to confirm our results in other populations.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Maraki MI
Department of Nutrition and Dietetics, School of Health Sciences, Hellenic Mediterranean University, Crete, Greece. Section of Sport Medicine and Biology of Exercise, School of Physical Education and Sport Science, National and Kapodistrian University of Athens, Athens, Greece.
Yannakoulia M
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Xiromerisiou G
School of Medicine, University of Thessaly, Larissa, Greece.
Stefanis L
Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece. First Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Greece.
Charisis S
First Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Greece. Department of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Giagkou N
First Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Greece.
Kosmidis MH
Laboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Dardiotis E
School of Medicine, University of Thessaly, Larissa, Greece.
Hadjigeorgiou GM
Department of Neurology, Medical School, University of Cyprus.
Sakka P
Athens Association of Alzheimer's Disease and Related Disorders, Marousi, Greece.
Scarmeas N
First Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Greece. Department of Neurology, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University, New York, USA.
Stamelou M
First Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Greece. Parkinson's Disease and Movement Disorders Department HYGEIA Hospital, Athens, Greece.

MeSH

HumansAgedLongitudinal StudiesParkinson DiseaseLewy Body DiseaseDiet, MediterraneanProbability

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

36692092

Citation

Maraki, Maria I., et al. "Mediterranean Diet Is Associated With a Lower Probability of Prodromal Parkinson's Disease and Risk for Parkinson's Disease/dementia With Lewy Bodies: a Longitudinal Study." European Journal of Neurology, vol. 30, no. 4, 2023, pp. 934-942.
Maraki MI, Yannakoulia M, Xiromerisiou G, et al. Mediterranean diet is associated with a lower probability of prodromal Parkinson's disease and risk for Parkinson's disease/dementia with Lewy bodies: A longitudinal study. Eur J Neurol. 2023;30(4):934-942.
Maraki, M. I., Yannakoulia, M., Xiromerisiou, G., Stefanis, L., Charisis, S., Giagkou, N., Kosmidis, M. H., Dardiotis, E., Hadjigeorgiou, G. M., Sakka, P., Scarmeas, N., & Stamelou, M. (2023). Mediterranean diet is associated with a lower probability of prodromal Parkinson's disease and risk for Parkinson's disease/dementia with Lewy bodies: A longitudinal study. European Journal of Neurology, 30(4), 934-942. https://doi.org/10.1111/ene.15698
Maraki MI, et al. Mediterranean Diet Is Associated With a Lower Probability of Prodromal Parkinson's Disease and Risk for Parkinson's Disease/dementia With Lewy Bodies: a Longitudinal Study. Eur J Neurol. 2023;30(4):934-942. PubMed PMID: 36692092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mediterranean diet is associated with a lower probability of prodromal Parkinson's disease and risk for Parkinson's disease/dementia with Lewy bodies: A longitudinal study. AU - Maraki,Maria I, AU - Yannakoulia,Mary, AU - Xiromerisiou,Georgia, AU - Stefanis,Leonidas, AU - Charisis,Sokratis, AU - Giagkou,Nikolaos, AU - Kosmidis,Mary H, AU - Dardiotis,Efthimios, AU - Hadjigeorgiou,Georgios M, AU - Sakka,Paraskevi, AU - Scarmeas,Nikolaos, AU - Stamelou,Maria, Y1 - 2023/02/06/ PY - 2023/01/14/revised PY - 2022/07/21/received PY - 2023/01/18/accepted PY - 2023/1/25/pubmed PY - 2023/3/8/medline PY - 2023/1/24/entrez KW - Mediterranean KW - elderly KW - neurodegeneration KW - nutrition KW - prodromal SP - 934 EP - 942 JF - European journal of neurology JO - Eur J Neurol VL - 30 IS - 4 N2 - BACKGROUND AND PURPOSE: Lifestyle factors have been implicated in the long-lasting neurodegenerative process in prodromal Parkinson's disease (pPD). The aim was to investigate the associations between adherence to a Mediterranean diet (MeDi) and longitudinal changes of pPD probability and the development of Parkinson's disease (PD) or pPD in a Mediterranean older population. METHODS: Data from the Hellenic Longitudinal Investigation of Aging and Diet cohort (community-dwelling individuals, aged ≥ 65 years) were used. A detailed food frequency questionnaire was used to evaluate dietary intake and calculate MeDi adherence score, ranging from 0 to 55, with higher scores indicating higher adherence. The probability of pPD was calculated according to the updated Movement Disorder Society research criteria. RESULTS: In all, 1047 non-PD/dementia with Lewy bodies (DLB) participants were followed for 3 ± 1 years. MeDi adherence was associated with lower increase in pPD probability over time (b = -0.003, 95% confidence interval -0.006 to -0.001, p = 0.010). Forty-nine participants had incident possible/probable pPD (i.e., pPD probability ≥ 30%). Compared to the participants in the lowest quartile of MeDi adherence, those in the higher quartiles had an approximately 60%-70% lower risk for possible/probable pPD (p for trend 0.003). MeDi-pPD associations were driven by both motor and non-motor pPD markers and not from risk markers. Also, 21 participants were diagnosed with PD/DLB at follow-up. For each unit increase in the MeDi score, there was a 9%-10% lower risk for PD/DLB (hazard ratio 0.906 [95% confidence interval 0.823-0.997], p = 0.044). CONCLUSIONS: Mediterranean diet adherence is associated with lower increase in pPD probability over time and lower possible/probable pPD and PD/DLB incidence in older Mediterranean people. More studies are needed to confirm our results in other populations. SN - 1468-1331 UR - https://www.unboundmedicine.com/medline/citation/36692092/Mediterranean_diet_is_associated_with_a_lower_probability_of_prodromal_Parkinson's_disease_and_risk_for_Parkinson's_disease/dementia_with_Lewy_bodies:_A_longitudinal_study_ DB - PRIME DP - Unbound Medicine ER -