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A comparison between concentrations of free erythrocyte protoporphyrin and serum ferritin during development of iron deficiency by phlebotomy in polycythaemia vera patients.
Scand J Clin Lab Invest. 1987 Oct; 47(6):593-7.SJ

Abstract

Therapeutic venesection for polycythaemia vera (PV) produces iron deficiency. If iron supplementation is avoided, the frequency of venesections can be kept lower than if iron is given. This is the standard treatment for PV in our department, and this model for iron deficiency was used to compare serum ferritin, free erythrocyte protoporphyrin (FEP), serum iron and transferrin as indicators of iron deficiency. Eleven patients with PV were studied on a total of 90 occasions. Five patients were followed from normal iron status to iron deficiency, the other six were iron deficient at the start of the study. Serum ferritin and FEP became abnormal approximately simultaneously during the development of iron deficiency, serum ferritin in all patients, FEP in 8 out of 11 patients. There was a correlation between the two in all specimens (r = 0.75, p less than 0.001), but serum ferritin showed fewer false negative results. Serum transferrin alone was elevated only in 25% of the patients, and serum iron, although mostly subnormal, was rather inconsistent. It is concluded that serum ferritin and FEP can both be used to diagnose iron deficiency during venesection treatment of PV, whereas serum iron and transferrin are of little value.

Authors+Show Affiliations

Department of Internal Medicine, University Hospital, Uppsala, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3672032

Citation

Birgegård, G, et al. "A Comparison Between Concentrations of Free Erythrocyte Protoporphyrin and Serum Ferritin During Development of Iron Deficiency By Phlebotomy in Polycythaemia Vera Patients." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 47, no. 6, 1987, pp. 593-7.
Birgegård G, de Verdier CH, Högman C. A comparison between concentrations of free erythrocyte protoporphyrin and serum ferritin during development of iron deficiency by phlebotomy in polycythaemia vera patients. Scand J Clin Lab Invest. 1987;47(6):593-7.
Birgegård, G., de Verdier, C. H., & Högman, C. (1987). A comparison between concentrations of free erythrocyte protoporphyrin and serum ferritin during development of iron deficiency by phlebotomy in polycythaemia vera patients. Scandinavian Journal of Clinical and Laboratory Investigation, 47(6), 593-7.
Birgegård G, de Verdier CH, Högman C. A Comparison Between Concentrations of Free Erythrocyte Protoporphyrin and Serum Ferritin During Development of Iron Deficiency By Phlebotomy in Polycythaemia Vera Patients. Scand J Clin Lab Invest. 1987;47(6):593-7. PubMed PMID: 3672032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison between concentrations of free erythrocyte protoporphyrin and serum ferritin during development of iron deficiency by phlebotomy in polycythaemia vera patients. AU - Birgegård,G, AU - de Verdier,C H, AU - Högman,C, PY - 1987/10/1/pubmed PY - 1987/10/1/medline PY - 1987/10/1/entrez SP - 593 EP - 7 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand J Clin Lab Invest VL - 47 IS - 6 N2 - Therapeutic venesection for polycythaemia vera (PV) produces iron deficiency. If iron supplementation is avoided, the frequency of venesections can be kept lower than if iron is given. This is the standard treatment for PV in our department, and this model for iron deficiency was used to compare serum ferritin, free erythrocyte protoporphyrin (FEP), serum iron and transferrin as indicators of iron deficiency. Eleven patients with PV were studied on a total of 90 occasions. Five patients were followed from normal iron status to iron deficiency, the other six were iron deficient at the start of the study. Serum ferritin and FEP became abnormal approximately simultaneously during the development of iron deficiency, serum ferritin in all patients, FEP in 8 out of 11 patients. There was a correlation between the two in all specimens (r = 0.75, p less than 0.001), but serum ferritin showed fewer false negative results. Serum transferrin alone was elevated only in 25% of the patients, and serum iron, although mostly subnormal, was rather inconsistent. It is concluded that serum ferritin and FEP can both be used to diagnose iron deficiency during venesection treatment of PV, whereas serum iron and transferrin are of little value. SN - 0036-5513 UR - https://www.unboundmedicine.com/medline/citation/3672032/A_comparison_between_concentrations_of_free_erythrocyte_protoporphyrin_and_serum_ferritin_during_development_of_iron_deficiency_by_phlebotomy_in_polycythaemia_vera_patients_ L2 - https://medlineplus.gov/iron.html DB - PRIME DP - Unbound Medicine ER -