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SARS-CoV-2 elicits non-sterilizing immunity and evades vaccine-induced immunity: implications for future vaccination strategies.
Eur J Epidemiol. 2023 Mar; 38(3):237-242.EJ

Abstract

Neither vaccination nor natural infection result in long-lasting protection against SARS-COV-2 infection and transmission, but both reduce the risk of severe COVID-19. To generate insights into optimal vaccination strategies for prevention of severe COVID-19 in the population, we extended a Susceptible-Exposed-Infectious-Removed (SEIR) mathematical model to compare the impact of vaccines that are highly protective against severe COVID-19 but not against infection and transmission, with those that block SARS-CoV-2 infection. Our analysis shows that vaccination strategies focusing on the prevention of severe COVID-19 are more effective than those focusing on creating of herd immunity. Key uncertainties that would affect the choice of vaccination strategies are: (1) the duration of protection against severe disease, (2) the protection against severe disease from variants that escape vaccine-induced immunity, (3) the incidence of long-COVID and level of protection provided by the vaccine, and (4) the rate of serious adverse events following vaccination, stratified by demographic variables.

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Authors+Show Affiliations

Beukenhorst AL
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. anna.beukenhorst@leydenlabs.com. Centre for Epidemiology Versus Arthritis, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. anna.beukenhorst@leydenlabs.com. Leyden Laboratories BV, Amsterdam, The Netherlands. anna.beukenhorst@leydenlabs.com.
Koch CM
Leyden Laboratories BV, Amsterdam, The Netherlands.
Hadjichrysanthou C
Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, UK.
Alter G
Ragon Institute of MGH MIT and Harvard, Cambridge, MA, USA.
de Wolf F
Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, UK.
Anderson RM
Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, UK.
Goudsmit J
Leyden Laboratories BV, Amsterdam, The Netherlands. Departments of Epidemiology, Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, MA, USA.

MeSH

HumansSARS-CoV-2Post-Acute COVID-19 SyndromeCOVID-19VaccinationVaccines

Pub Type(s)

Journal Article

Language

eng

PubMed ID

36738380

Citation

Beukenhorst, Anna L., et al. "SARS-CoV-2 Elicits Non-sterilizing Immunity and Evades Vaccine-induced Immunity: Implications for Future Vaccination Strategies." European Journal of Epidemiology, vol. 38, no. 3, 2023, pp. 237-242.
Beukenhorst AL, Koch CM, Hadjichrysanthou C, et al. SARS-CoV-2 elicits non-sterilizing immunity and evades vaccine-induced immunity: implications for future vaccination strategies. Eur J Epidemiol. 2023;38(3):237-242.
Beukenhorst, A. L., Koch, C. M., Hadjichrysanthou, C., Alter, G., de Wolf, F., Anderson, R. M., & Goudsmit, J. (2023). SARS-CoV-2 elicits non-sterilizing immunity and evades vaccine-induced immunity: implications for future vaccination strategies. European Journal of Epidemiology, 38(3), 237-242. https://doi.org/10.1007/s10654-023-00965-x
Beukenhorst AL, et al. SARS-CoV-2 Elicits Non-sterilizing Immunity and Evades Vaccine-induced Immunity: Implications for Future Vaccination Strategies. Eur J Epidemiol. 2023;38(3):237-242. PubMed PMID: 36738380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV-2 elicits non-sterilizing immunity and evades vaccine-induced immunity: implications for future vaccination strategies. AU - Beukenhorst,Anna L, AU - Koch,Clarissa M, AU - Hadjichrysanthou,Christoforos, AU - Alter,Galit, AU - de Wolf,Frank, AU - Anderson,Roy M, AU - Goudsmit,Jaap, Y1 - 2023/02/04/ PY - 2022/10/07/received PY - 2023/01/07/accepted PY - 2023/2/5/pubmed PY - 2023/3/25/medline PY - 2023/2/4/entrez KW - COVID-19 KW - Control measures KW - Coronavirus KW - Herd immunity KW - Immunology KW - Infection KW - Influenza KW - Population modelling KW - Respiratory infections KW - SARS-CoV-2 pandemic KW - Vaccine effectiveness KW - Vaccines SP - 237 EP - 242 JF - European journal of epidemiology JO - Eur J Epidemiol VL - 38 IS - 3 N2 - Neither vaccination nor natural infection result in long-lasting protection against SARS-COV-2 infection and transmission, but both reduce the risk of severe COVID-19. To generate insights into optimal vaccination strategies for prevention of severe COVID-19 in the population, we extended a Susceptible-Exposed-Infectious-Removed (SEIR) mathematical model to compare the impact of vaccines that are highly protective against severe COVID-19 but not against infection and transmission, with those that block SARS-CoV-2 infection. Our analysis shows that vaccination strategies focusing on the prevention of severe COVID-19 are more effective than those focusing on creating of herd immunity. Key uncertainties that would affect the choice of vaccination strategies are: (1) the duration of protection against severe disease, (2) the protection against severe disease from variants that escape vaccine-induced immunity, (3) the incidence of long-COVID and level of protection provided by the vaccine, and (4) the rate of serious adverse events following vaccination, stratified by demographic variables. SN - 1573-7284 UR - https://www.unboundmedicine.com/medline/citation/36738380/SARS_CoV_2_elicits_non_sterilizing_immunity_and_evades_vaccine_induced_immunity:_implications_for_future_vaccination_strategies_ DB - PRIME DP - Unbound Medicine ER -