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Disuse atrophy, plasma corticosterone, and muscle glucocorticoid receptor levels.
Aviat Space Environ Med. 1987 Oct; 58(10):996-1000.AS

Abstract

A suspension model, characterized by differential atrophy of disused hindlimb skeletal muscles, was utilized to investigate plasma levels of and tissue sensitivity to glucocorticoids. The three objectives were determination of time course and extent of plasma corticosterone changes during 1 week of whole-body suspension; comparison of glucocorticoid receptor site concentrations in muscles differing in morphology and antigravity function; and investigation of the effect of disuse on tissue glucocorticoid receptor site concentrations. Plasma corticosterone increased significantly (p less than 0.01) on the first and third days of suspension, but returned to control levels by day 7. Muscle glucocorticoid receptors exhibited a characteristic hormonal specificity. In controls, receptor site concentration in the slow-twitch soleus (48 +/- 5 fmol/mg prot.) was comparable to that in the fast-twitch gastrocnemius (47 +/- 6) and plantaris (58 +/- 4) muscles but significantly (p less than 0.02) less than the extensor digitorum longus (66 +/- 5). Seven days of suspension resulted in significant differential effects on muscle receptor levels, with a large increase in the soleus (140%), lesser increments in the gastrocnemius (55%) and plantaris (45%), and only a small, statistically insignificant alteration in the EDL (10%). Receptor levels in the soleus remained elevated following 14 d of suspension, but levels in other muscles returned to control values. These results suggest that circulating glucocorticoids, as well as increased tissue hormonal sensitivity, may be related to muscle responses in this model of disuse.

Authors+Show Affiliations

Department of Physiology and Biophysics, School of Medicine, University of Louisville, KY 40292.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

3675473

Citation

Steffen, J M., and X J. Musacchia. "Disuse Atrophy, Plasma Corticosterone, and Muscle Glucocorticoid Receptor Levels." Aviation, Space, and Environmental Medicine, vol. 58, no. 10, 1987, pp. 996-1000.
Steffen JM, Musacchia XJ. Disuse atrophy, plasma corticosterone, and muscle glucocorticoid receptor levels. Aviat Space Environ Med. 1987;58(10):996-1000.
Steffen, J. M., & Musacchia, X. J. (1987). Disuse atrophy, plasma corticosterone, and muscle glucocorticoid receptor levels. Aviation, Space, and Environmental Medicine, 58(10), 996-1000.
Steffen JM, Musacchia XJ. Disuse Atrophy, Plasma Corticosterone, and Muscle Glucocorticoid Receptor Levels. Aviat Space Environ Med. 1987;58(10):996-1000. PubMed PMID: 3675473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disuse atrophy, plasma corticosterone, and muscle glucocorticoid receptor levels. AU - Steffen,J M, AU - Musacchia,X J, PY - 1987/10/1/pubmed PY - 1987/10/1/medline PY - 1987/10/1/entrez SP - 996 EP - 1000 JF - Aviation, space, and environmental medicine JO - Aviat Space Environ Med VL - 58 IS - 10 N2 - A suspension model, characterized by differential atrophy of disused hindlimb skeletal muscles, was utilized to investigate plasma levels of and tissue sensitivity to glucocorticoids. The three objectives were determination of time course and extent of plasma corticosterone changes during 1 week of whole-body suspension; comparison of glucocorticoid receptor site concentrations in muscles differing in morphology and antigravity function; and investigation of the effect of disuse on tissue glucocorticoid receptor site concentrations. Plasma corticosterone increased significantly (p less than 0.01) on the first and third days of suspension, but returned to control levels by day 7. Muscle glucocorticoid receptors exhibited a characteristic hormonal specificity. In controls, receptor site concentration in the slow-twitch soleus (48 +/- 5 fmol/mg prot.) was comparable to that in the fast-twitch gastrocnemius (47 +/- 6) and plantaris (58 +/- 4) muscles but significantly (p less than 0.02) less than the extensor digitorum longus (66 +/- 5). Seven days of suspension resulted in significant differential effects on muscle receptor levels, with a large increase in the soleus (140%), lesser increments in the gastrocnemius (55%) and plantaris (45%), and only a small, statistically insignificant alteration in the EDL (10%). Receptor levels in the soleus remained elevated following 14 d of suspension, but levels in other muscles returned to control values. These results suggest that circulating glucocorticoids, as well as increased tissue hormonal sensitivity, may be related to muscle responses in this model of disuse. SN - 0095-6562 UR - https://www.unboundmedicine.com/medline/citation/3675473/Disuse_atrophy_plasma_corticosterone_and_muscle_glucocorticoid_receptor_levels_ DB - PRIME DP - Unbound Medicine ER -