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Renal vascular effects of leukotriene C4 in the isolated perfused kidney of the rat.
Br J Pharmacol. 1987 Oct; 92(2):311-8.BJ

Abstract

1 The vascular effects of leukotriene C4 (LTC4) were investigated in the isolated perfused kidney of the rat. 2 LTC4 (6.4 X 10(-10) to 3.2 X 10(-8) mol kg-1 min-1 given over 5 min) resulted in a prompt, dose-dependent increase in renal vascular resistance in a recirculating system, which lasted for more than 60 min. 3 LTC4 was 10 to 20 fold and 1000 to 2000 fold, respectively, less active on a molar basis than noradrenaline and angiotensin II in eliciting renal vasoconstriction. 4 The vascular response to LTC4 was blocked dose-dependently by FPL 55712, an antagonist of slow reacting substance of anaphylaxis. OKY 1581, a specific thromboxane synthetase inhibitor, and indomethacin, a cyclo-oxygenase inhibitor, did not influence the LTC4 response. 5 LTC4 given in a single-pass perfusion system resulted in a short lasting response with baseline values for renal vascular resistance reached after 4 min. 6 These results show that LTC4 is a short acting renal vasoconstrictor with less potency than noradrenaline and angiotensin II. Its pressor effects seem to be mediated by specific leukotriene receptors and independent of cyclo-oxygenase products. The long-lasting effect in the recirculating arrangement, in contrast to the single pass system, is compatible with formation of active metabolite(s).

Authors+Show Affiliations

Department of Clinical Pharmacology, Hannover Medical School, Germany.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3676595

Citation

Frölich, J C., and M Yoshizawa. "Renal Vascular Effects of Leukotriene C4 in the Isolated Perfused Kidney of the Rat." British Journal of Pharmacology, vol. 92, no. 2, 1987, pp. 311-8.
Frölich JC, Yoshizawa M. Renal vascular effects of leukotriene C4 in the isolated perfused kidney of the rat. Br J Pharmacol. 1987;92(2):311-8.
Frölich, J. C., & Yoshizawa, M. (1987). Renal vascular effects of leukotriene C4 in the isolated perfused kidney of the rat. British Journal of Pharmacology, 92(2), 311-8.
Frölich JC, Yoshizawa M. Renal Vascular Effects of Leukotriene C4 in the Isolated Perfused Kidney of the Rat. Br J Pharmacol. 1987;92(2):311-8. PubMed PMID: 3676595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Renal vascular effects of leukotriene C4 in the isolated perfused kidney of the rat. AU - Frölich,J C, AU - Yoshizawa,M, PY - 1987/10/1/pubmed PY - 1987/10/1/medline PY - 1987/10/1/entrez SP - 311 EP - 8 JF - British journal of pharmacology JO - Br J Pharmacol VL - 92 IS - 2 N2 - 1 The vascular effects of leukotriene C4 (LTC4) were investigated in the isolated perfused kidney of the rat. 2 LTC4 (6.4 X 10(-10) to 3.2 X 10(-8) mol kg-1 min-1 given over 5 min) resulted in a prompt, dose-dependent increase in renal vascular resistance in a recirculating system, which lasted for more than 60 min. 3 LTC4 was 10 to 20 fold and 1000 to 2000 fold, respectively, less active on a molar basis than noradrenaline and angiotensin II in eliciting renal vasoconstriction. 4 The vascular response to LTC4 was blocked dose-dependently by FPL 55712, an antagonist of slow reacting substance of anaphylaxis. OKY 1581, a specific thromboxane synthetase inhibitor, and indomethacin, a cyclo-oxygenase inhibitor, did not influence the LTC4 response. 5 LTC4 given in a single-pass perfusion system resulted in a short lasting response with baseline values for renal vascular resistance reached after 4 min. 6 These results show that LTC4 is a short acting renal vasoconstrictor with less potency than noradrenaline and angiotensin II. Its pressor effects seem to be mediated by specific leukotriene receptors and independent of cyclo-oxygenase products. The long-lasting effect in the recirculating arrangement, in contrast to the single pass system, is compatible with formation of active metabolite(s). SN - 0007-1188 UR - https://www.unboundmedicine.com/medline/citation/3676595/Renal_vascular_effects_of_leukotriene_C4_in_the_isolated_perfused_kidney_of_the_rat_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-1188&date=1987&volume=92&issue=2&spage=311 DB - PRIME DP - Unbound Medicine ER -