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Combined iron deficiency and lead poisoning in children. Effect on FEP levels.
Clin Pediatr (Phila). 1987 Dec; 26(12):644-7.CPed

Abstract

Concern for the concomitant occurrence of iron deficiency and elevated blood lead in children is raised by animal studies documenting increased gastrointestinal lead absorption in the presence of iron deficiency. An elevation in free erythrocyte protoporphyrin (FEP) above 35 mg/dl is seen with both iron deficiency and lead toxicity. To determine whether the degree of elevation in FEP is useful in predicting which children with elevated blood lead levels have concomitant iron deficiency, 109 children suspected of having an elevated lead burden were studied. A complete blood count, reticulocyte count, FEP, lead, and ferritin were measured on each child. The effect of the independent variables, lead and iron status, both alone and in combination, on the dependent variable, FEP, was analyzed through a linear regression model. Lead status alone accounted for 42 percent of the explained variance in FEP, and the lead-iron interaction increased the explained variance by only an additional 1 percent. Screening for iron deficiency in children with elevated blood lead should continue to be based on dietary and socioeconomic risk factors and not on degree of elevation in FEP.

Authors+Show Affiliations

Department of Pediatrics, University of Maryland, Baltimore 21201.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3677534

Citation

Carraccio, C L., et al. "Combined Iron Deficiency and Lead Poisoning in Children. Effect On FEP Levels." Clinical Pediatrics, vol. 26, no. 12, 1987, pp. 644-7.
Carraccio CL, Bergman GE, Daley BP. Combined iron deficiency and lead poisoning in children. Effect on FEP levels. Clin Pediatr (Phila). 1987;26(12):644-7.
Carraccio, C. L., Bergman, G. E., & Daley, B. P. (1987). Combined iron deficiency and lead poisoning in children. Effect on FEP levels. Clinical Pediatrics, 26(12), 644-7.
Carraccio CL, Bergman GE, Daley BP. Combined Iron Deficiency and Lead Poisoning in Children. Effect On FEP Levels. Clin Pediatr (Phila). 1987;26(12):644-7. PubMed PMID: 3677534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined iron deficiency and lead poisoning in children. Effect on FEP levels. AU - Carraccio,C L, AU - Bergman,G E, AU - Daley,B P, PY - 1987/12/1/pubmed PY - 1987/12/1/medline PY - 1987/12/1/entrez SP - 644 EP - 7 JF - Clinical pediatrics JO - Clin Pediatr (Phila) VL - 26 IS - 12 N2 - Concern for the concomitant occurrence of iron deficiency and elevated blood lead in children is raised by animal studies documenting increased gastrointestinal lead absorption in the presence of iron deficiency. An elevation in free erythrocyte protoporphyrin (FEP) above 35 mg/dl is seen with both iron deficiency and lead toxicity. To determine whether the degree of elevation in FEP is useful in predicting which children with elevated blood lead levels have concomitant iron deficiency, 109 children suspected of having an elevated lead burden were studied. A complete blood count, reticulocyte count, FEP, lead, and ferritin were measured on each child. The effect of the independent variables, lead and iron status, both alone and in combination, on the dependent variable, FEP, was analyzed through a linear regression model. Lead status alone accounted for 42 percent of the explained variance in FEP, and the lead-iron interaction increased the explained variance by only an additional 1 percent. Screening for iron deficiency in children with elevated blood lead should continue to be based on dietary and socioeconomic risk factors and not on degree of elevation in FEP. SN - 0009-9228 UR - https://www.unboundmedicine.com/medline/citation/3677534/Combined_iron_deficiency_and_lead_poisoning_in_children__Effect_on_FEP_levels_ L2 - https://journals.sagepub.com/doi/10.1177/000992288702601206?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -