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Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic.
Cell. 2023 03 02; 186(5):906-922.Cell

Abstract

ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the COVID-19 pandemic, it has become one of the most therapeutically targeted human molecules in biomedicine. ACE2 serves two fundamental physiological roles: as an enzyme, it alters peptide cascade balance; as a chaperone, it controls intestinal amino acid uptake. ACE2's tissue distribution, affected by co-morbidities and sex, explains the broad tropism of coronaviruses and the clinical manifestations of SARS and COVID-19. ACE2-based therapeutics provide a universal strategy to prevent and treat SARS-CoV-2 infections, applicable to all SARS-CoV-2 variants and other emerging zoonotic coronaviruses exploiting ACE2 as their cellular receptor.

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Authors+Show Affiliations

Oudit GY
Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada. Electronic address: gavin.oudit@ualberta.ca.
Wang K
Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.
Viveiros A
Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.
Kellner MJ
Institute of Molecular Biotechnology of the Austrian Academy of Science, Vienna, Austria.
Penninger JM
Institute of Molecular Biotechnology of the Austrian Academy of Science, Vienna, Austria; Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada. Electronic address: josef.penninger@ubc.ca.

MeSH

HumansCOVID-19SARS-CoV-2Angiotensin-Converting Enzyme 2Peptidyl-Dipeptidase APandemicsSevere acute respiratory syndrome-related coronavirus

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

36787743

Citation

Oudit, Gavin Y., et al. "Angiotensin-converting Enzyme 2-at the Heart of the COVID-19 Pandemic." Cell, vol. 186, no. 5, 2023, pp. 906-922.
Oudit GY, Wang K, Viveiros A, et al. Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic. Cell. 2023;186(5):906-922.
Oudit, G. Y., Wang, K., Viveiros, A., Kellner, M. J., & Penninger, J. M. (2023). Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic. Cell, 186(5), 906-922. https://doi.org/10.1016/j.cell.2023.01.039
Oudit GY, et al. Angiotensin-converting Enzyme 2-at the Heart of the COVID-19 Pandemic. Cell. 2023 03 2;186(5):906-922. PubMed PMID: 36787743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic. AU - Oudit,Gavin Y, AU - Wang,Kaiming, AU - Viveiros,Anissa, AU - Kellner,Max J, AU - Penninger,Josef M, Y1 - 2023/02/02/ PY - 2022/10/07/received PY - 2022/12/06/revised PY - 2023/01/26/accepted PY - 2023/2/15/pubmed PY - 2023/3/8/medline PY - 2023/2/14/entrez SP - 906 EP - 922 JF - Cell JO - Cell VL - 186 IS - 5 N2 - ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the COVID-19 pandemic, it has become one of the most therapeutically targeted human molecules in biomedicine. ACE2 serves two fundamental physiological roles: as an enzyme, it alters peptide cascade balance; as a chaperone, it controls intestinal amino acid uptake. ACE2's tissue distribution, affected by co-morbidities and sex, explains the broad tropism of coronaviruses and the clinical manifestations of SARS and COVID-19. ACE2-based therapeutics provide a universal strategy to prevent and treat SARS-CoV-2 infections, applicable to all SARS-CoV-2 variants and other emerging zoonotic coronaviruses exploiting ACE2 as their cellular receptor. SN - 1097-4172 UR - https://www.unboundmedicine.com/medline/citation/36787743/Angiotensin_converting_enzyme_2_at_the_heart_of_the_COVID_19_pandemic_ DB - PRIME DP - Unbound Medicine ER -