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Neurodegeneration cell per cell.
Neuron. 2023 03 15; 111(6):767-786.N

Abstract

The clinical definition of neurodegenerative diseases is based on symptoms that reflect terminal damage of specific brain regions. This is misleading as it tells little about the initial disease processes. Circuitry failures that underlie the clinical symptomatology are themselves preceded by clinically mostly silent, slowly progressing multicellular processes that trigger or are triggered by the accumulation of abnormally folded proteins such as Aβ, Tau, TDP-43, and α-synuclein, among others. Methodological advances in single-cell omics, combined with complex genetics and novel ways to model complex cellular interactions using induced pluripotent stem (iPS) cells, make it possible to analyze the early cellular phase of neurodegenerative disorders. This will revolutionize the way we study those diseases and will translate into novel diagnostics and cell-specific therapeutic targets, stopping these disorders in their early track before they cause difficult-to-reverse damage to the brain.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Balusu S
VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven Department of Neurosciences, Leuven Brain Institute, Leuven, Belgium.
Praschberger R
VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven Department of Neurosciences, Leuven Brain Institute, Leuven, Belgium.
Lauwers E
VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven Department of Neurosciences, Leuven Brain Institute, Leuven, Belgium.
De Strooper B
VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven Department of Neurosciences, Leuven Brain Institute, Leuven, Belgium; UK Dementia Research Institute, London, UK. Electronic address: bart.destrooper@kuleuven.be.
Verstreken P
VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven Department of Neurosciences, Leuven Brain Institute, Leuven, Belgium. Electronic address: patrik.verstreken@kuleuven.be.

MeSH

HumansAlzheimer Diseasealpha-SynucleinBraintau Proteins

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

36787752

Citation

Balusu, Sriram, et al. "Neurodegeneration Cell Per Cell." Neuron, vol. 111, no. 6, 2023, pp. 767-786.
Balusu S, Praschberger R, Lauwers E, et al. Neurodegeneration cell per cell. Neuron. 2023;111(6):767-786.
Balusu, S., Praschberger, R., Lauwers, E., De Strooper, B., & Verstreken, P. (2023). Neurodegeneration cell per cell. Neuron, 111(6), 767-786. https://doi.org/10.1016/j.neuron.2023.01.016
Balusu S, et al. Neurodegeneration Cell Per Cell. Neuron. 2023 03 15;111(6):767-786. PubMed PMID: 36787752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurodegeneration cell per cell. AU - Balusu,Sriram, AU - Praschberger,Roman, AU - Lauwers,Elsa, AU - De Strooper,Bart, AU - Verstreken,Patrik, Y1 - 2023/02/13/ PY - 2022/09/08/received PY - 2022/10/12/revised PY - 2023/01/18/accepted PY - 2023/2/15/pubmed PY - 2023/3/21/medline PY - 2023/2/14/entrez KW - Alzheimer’s disease KW - Parkinson’s disease KW - neurodegeneration KW - single-cell sequencing SP - 767 EP - 786 JF - Neuron JO - Neuron VL - 111 IS - 6 N2 - The clinical definition of neurodegenerative diseases is based on symptoms that reflect terminal damage of specific brain regions. This is misleading as it tells little about the initial disease processes. Circuitry failures that underlie the clinical symptomatology are themselves preceded by clinically mostly silent, slowly progressing multicellular processes that trigger or are triggered by the accumulation of abnormally folded proteins such as Aβ, Tau, TDP-43, and α-synuclein, among others. Methodological advances in single-cell omics, combined with complex genetics and novel ways to model complex cellular interactions using induced pluripotent stem (iPS) cells, make it possible to analyze the early cellular phase of neurodegenerative disorders. This will revolutionize the way we study those diseases and will translate into novel diagnostics and cell-specific therapeutic targets, stopping these disorders in their early track before they cause difficult-to-reverse damage to the brain. SN - 1097-4199 UR - https://www.unboundmedicine.com/medline/citation/36787752/Neurodegeneration_cell_per_cell_ DB - PRIME DP - Unbound Medicine ER -