Association of Red Blood Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio with Calcification and Cardiovascular Markers in Chronic Kidney Disease.
Metabolites. 2023 Feb 17; 13(2)M

Abstract

We aimed to investigate the association between Red Blood Cell Distribution Width (RDW) and Neutrophil-to-Lymphocyte Ratio (NLR), simple, rapidly assessed markers from the complete blood count with vascular calcification (VC)/stiffness and cardiovascular disease (CVD) in chronic kidney disease (CKD). Dephosphorylated, uncarboxylated matrix Gla-protein (dp-ucMGP), and central/peripheral hemodynamics' parameters were measured in 158 CKD patients, including Hemodialysis and Peritoneal Dialysis. Spearman's rho analysis showed that RDW correlated with C-reactive protein (CRP) (r = 0.29, p < 0.001), dp-ucMGP (r = 0.43, p = < 0.0001), central diastolic blood pressure (DBP) (r = -0.19, p = 0.02), and albuminuria (r = -0.17, p = 0.03). NLR correlated with the duration of CVD (r = 0.32, p < 0.001), CRP (r = 0.27, p = 0.01), dp-ucMGP (r = 0.43, p < 0.0001), central DBP (r = -0.32, p < 0.0001) and eGFR (r = -0.25, p = 0.04). In multiple regression models, circulating dp-ucMGP was an independent predictor of RDW (β = 0.001, p = 0.001) and NLR (β = 0.002, p = 0.002). In CKD patients, RDW and NLR are associated with traditional and novel markers of VC and CVD.

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Roumeliotis S

Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.

Neofytou IE

Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.

Maassen C

Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands.

Lux P

Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands.

Kantartzi K

Department of Nephrology, Democritus University of Thrace, 68100 Alexandroupolis, Greece.

Papachristou E

Department of Nephrology and Renal Transplantation, Patras University Hospital, 26504 Patras, Greece.

Schurgers LJ

Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands.

Liakopoulos V

Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

36837922

Citation

Roumeliotis, Stefanos, et al. "Association of Red Blood Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio With Calcification and Cardiovascular Markers in Chronic Kidney Disease." Metabolites, vol. 13, no. 2, 2023.

Roumeliotis S, Neofytou IE, Maassen C, et al. Association of Red Blood Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio with Calcification and Cardiovascular Markers in Chronic Kidney Disease. Metabolites. 2023;13(2).

Roumeliotis, S., Neofytou, I. E., Maassen, C., Lux, P., Kantartzi, K., Papachristou, E., Schurgers, L. J., & Liakopoulos, V. (2023). Association of Red Blood Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio with Calcification and Cardiovascular Markers in Chronic Kidney Disease. Metabolites, 13(2). https://doi.org/10.3390/metabo13020303

Roumeliotis S, et al. Association of Red Blood Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio With Calcification and Cardiovascular Markers in Chronic Kidney Disease. Metabolites. 2023 Feb 17;13(2) PubMed PMID: 36837922.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Association of Red Blood Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio with Calcification and Cardiovascular Markers in Chronic Kidney Disease. AU - Roumeliotis,Stefanos, AU - Neofytou,Ioannis E, AU - Maassen,Cecile, AU - Lux,Petra, AU - Kantartzi,Konstantia, AU - Papachristou,Evangelos, AU - Schurgers,Leon J, AU - Liakopoulos,Vassilios, Y1 - 2023/02/17/ PY - 2023/1/13/received PY - 2023/2/10/revised PY - 2023/2/16/accepted PY - 2023/2/25/entrez PY - 2023/2/26/pubmed PY - 2023/2/26/medline KW - Neutrophil-to-lymphocyte ratio KW - cardiovascular disease KW - chronic kidney disease KW - dephosphorylatyed uncarboxylated Matrix Gla Protein KW - endothelial dysfunction KW - inflammation KW - red blood cell distribution width KW - vascular calcification JF - Metabolites JO - Metabolites VL - 13 IS - 2 N2 - We aimed to investigate the association between Red Blood Cell Distribution Width (RDW) and Neutrophil-to-Lymphocyte Ratio (NLR), simple, rapidly assessed markers from the complete blood count with vascular calcification (VC)/stiffness and cardiovascular disease (CVD) in chronic kidney disease (CKD). Dephosphorylated, uncarboxylated matrix Gla-protein (dp-ucMGP), and central/peripheral hemodynamics' parameters were measured in 158 CKD patients, including Hemodialysis and Peritoneal Dialysis. Spearman's rho analysis showed that RDW correlated with C-reactive protein (CRP) (r = 0.29, p < 0.001), dp-ucMGP (r = 0.43, p = < 0.0001), central diastolic blood pressure (DBP) (r = -0.19, p = 0.02), and albuminuria (r = -0.17, p = 0.03). NLR correlated with the duration of CVD (r = 0.32, p < 0.001), CRP (r = 0.27, p = 0.01), dp-ucMGP (r = 0.43, p < 0.0001), central DBP (r = -0.32, p < 0.0001) and eGFR (r = -0.25, p = 0.04). In multiple regression models, circulating dp-ucMGP was an independent predictor of RDW (β = 0.001, p = 0.001) and NLR (β = 0.002, p = 0.002). In CKD patients, RDW and NLR are associated with traditional and novel markers of VC and CVD. SN - 2218-1989 UR - https://www.unboundmedicine.com/medline/citation/36837922/Association_of_Red_Blood_Cell_Distribution_Width_and_Neutrophil_to_Lymphocyte_Ratio_with_Calcification_and_Cardiovascular_Markers_in_Chronic_Kidney_Disease_ DB - PRIME DP - Unbound Medicine ER -

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Association of Red Blood Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio with Calcification and Cardiovascular Markers in Chronic Kidney Disease.Metabolites. 2023 Feb 17; 13(2)M

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Association of Red Blood Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio with Calcification and Cardiovascular Markers in Chronic Kidney Disease.
Metabolites. 2023 Feb 17; 13(2)M