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Effects of apomorphine and amphetamine on patterns of locomotor and investigatory behavior in rats.
Pharmacol Biochem Behav 1987; 28(3):393-9PB

Abstract

Rats were tested in a Behavioral Pattern Monitor after various doses of either amphetamine or apomorphine in order to characterize their behavioral profiles, including patterns and sequences of holepokes, rearings and locomotor movements. To enable direct comparisons between the behavioral effects of the two stimulants, doses and times for each drug were selected with which locomotor hyperactivity was the predominant behavioral response. Although both drugs increased the total amount of locomotor activity, amphetamine induced a relatively varied behavioral profile while apomorphine induced repetitive behavior with a restricted range of responses. These contrasting effects of the stimulants were interpreted as reflective of their differing modes of action with regard to central dopaminergic systems. It is suggested that, in the dose range used, the release of dopamine by amphetamine is coupled to neuronal firing and therefore this release increases behavioral activity without altering the normal response repertoire of the animal. Conversely, the direct agonist action of apomorphine results in a restricted and perseverative behavioral pattern because its activation of forebrain dopamine receptors is independent of the normal physiological pattern of dopaminergic neuronal firing.

Authors+Show Affiliations

Department of Psychiatry, University of California, San Diego, La Jolla 92093.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3685075

Citation

Geyer, M A., et al. "Effects of Apomorphine and Amphetamine On Patterns of Locomotor and Investigatory Behavior in Rats." Pharmacology, Biochemistry, and Behavior, vol. 28, no. 3, 1987, pp. 393-9.
Geyer MA, Russo PV, Segal DS, et al. Effects of apomorphine and amphetamine on patterns of locomotor and investigatory behavior in rats. Pharmacol Biochem Behav. 1987;28(3):393-9.
Geyer, M. A., Russo, P. V., Segal, D. S., & Kuczenski, R. (1987). Effects of apomorphine and amphetamine on patterns of locomotor and investigatory behavior in rats. Pharmacology, Biochemistry, and Behavior, 28(3), pp. 393-9.
Geyer MA, et al. Effects of Apomorphine and Amphetamine On Patterns of Locomotor and Investigatory Behavior in Rats. Pharmacol Biochem Behav. 1987;28(3):393-9. PubMed PMID: 3685075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of apomorphine and amphetamine on patterns of locomotor and investigatory behavior in rats. AU - Geyer,M A, AU - Russo,P V, AU - Segal,D S, AU - Kuczenski,R, PY - 1987/11/1/pubmed PY - 1987/11/1/medline PY - 1987/11/1/entrez SP - 393 EP - 9 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 28 IS - 3 N2 - Rats were tested in a Behavioral Pattern Monitor after various doses of either amphetamine or apomorphine in order to characterize their behavioral profiles, including patterns and sequences of holepokes, rearings and locomotor movements. To enable direct comparisons between the behavioral effects of the two stimulants, doses and times for each drug were selected with which locomotor hyperactivity was the predominant behavioral response. Although both drugs increased the total amount of locomotor activity, amphetamine induced a relatively varied behavioral profile while apomorphine induced repetitive behavior with a restricted range of responses. These contrasting effects of the stimulants were interpreted as reflective of their differing modes of action with regard to central dopaminergic systems. It is suggested that, in the dose range used, the release of dopamine by amphetamine is coupled to neuronal firing and therefore this release increases behavioral activity without altering the normal response repertoire of the animal. Conversely, the direct agonist action of apomorphine results in a restricted and perseverative behavioral pattern because its activation of forebrain dopamine receptors is independent of the normal physiological pattern of dopaminergic neuronal firing. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/3685075/Effects_of_apomorphine_and_amphetamine_on_patterns_of_locomotor_and_investigatory_behavior_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-3057(87)90460-6 DB - PRIME DP - Unbound Medicine ER -