Citation
Chen, Yanxia, et al. "COVID-19 mRNA Vaccine Protects Against SARS-CoV-2 Omicron BA.1 Infection in Diet-induced Obese Mice Through Boosting Host Innate Antiviral Responses." EBioMedicine, vol. 89, 2023, p. 104485.
Chen Y, Song W, Li C, et al. COVID-19 mRNA vaccine protects against SARS-CoV-2 Omicron BA.1 infection in diet-induced obese mice through boosting host innate antiviral responses. EBioMedicine. 2023;89:104485.
Chen, Y., Song, W., Li, C., Wang, J., Liu, F., Ye, Z., Ren, P., Tong, Y., Li, J., Ou, Z., Lee, A. C., Cai, J. P., Wong, B. H., Chan, J. F., Yuen, K. Y., Zhang, A. J., & Chu, H. (2023). COVID-19 mRNA vaccine protects against SARS-CoV-2 Omicron BA.1 infection in diet-induced obese mice through boosting host innate antiviral responses. EBioMedicine, 89, 104485. https://doi.org/10.1016/j.ebiom.2023.104485
Chen Y, et al. COVID-19 mRNA Vaccine Protects Against SARS-CoV-2 Omicron BA.1 Infection in Diet-induced Obese Mice Through Boosting Host Innate Antiviral Responses. EBioMedicine. 2023;89:104485. PubMed PMID: 36857860.
TY - JOUR
T1 - COVID-19 mRNA vaccine protects against SARS-CoV-2 Omicron BA.1 infection in diet-induced obese mice through boosting host innate antiviral responses.
AU - Chen,Yanxia,
AU - Song,Wenchen,
AU - Li,Can,
AU - Wang,Jiaxuan,
AU - Liu,Feifei,
AU - Ye,Zhanhong,
AU - Ren,Peidi,
AU - Tong,Yihan,
AU - Li,Junhua,
AU - Ou,Zhihua,
AU - Lee,Andrew Chak-Yiu,
AU - Cai,Jian-Piao,
AU - Wong,Bosco Ho-Yin,
AU - Chan,Jasper Fuk-Woo,
AU - Yuen,Kwok-Yung,
AU - Zhang,Anna Jin-Xia,
AU - Chu,Hin,
Y1 - 2023/02/27/
PY - 2022/11/22/received
PY - 2023/02/03/revised
PY - 2023/02/03/accepted
PY - 2023/3/2/pubmed
PY - 2023/3/2/medline
PY - 2023/3/1/entrez
KW - COVID-19
KW - Diet-induced obese mouse
KW - Obesity
KW - Omicron
KW - SARS-CoV-2
KW - Vaccination
SP - 104485
EP - 104485
JF - EBioMedicine
JO - EBioMedicine
VL - 89
N2 - BACKGROUND: Obesity is a worldwide epidemic and is considered a risk factor of severe manifestation of Coronavirus Disease 2019 (COVID-19). The pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and host responses to infection, re-infection, and vaccination in individuals with obesity remain incompletely understood. METHODS: Using the diet-induced obese (DIO) mouse model, we studied SARS-CoV-2 Alpha- and Omicron BA.1-induced disease manifestations and host immune responses to infection, re-infection, and COVID-19 mRNA vaccination. FINDINGS: Unlike in lean mice, Omicron BA.1 and Alpha replicated to comparable levels in the lungs of DIO mice and resulted in similar degree of tissue damages. Importantly, both T cell and B cell mediated adaptive immune responses to SARS-CoV-2 infection or COVID-19 mRNA vaccination are impaired in DIO mice, leading to higher propensity of re-infection and lower vaccine efficacy. However, despite the absence of neutralizing antibody, vaccinated DIO mice are protected from lung damage upon Omicron challenge, accompanied with significantly more IFN-α and IFN-β production in the lung tissue. Lung RNAseq and subsequent experiments indicated that COVID-19 mRNA vaccination in DIO mice boosted antiviral innate immune response, including the expression of IFN-α, when compared to the nonvaccinated controls. INTERPRETATION: Our findings suggested that COVID-19 mRNA vaccination enhances host innate antiviral responses in obesity which protect the DIO mice to a certain degree when adaptive immunity is suboptimal. FUNDING: A full list of funding bodies that contributed to this study can be found in the Acknowledgements section.
SN - 2352-3964
UR - https://www.unboundmedicine.com/medline/citation/36857860/COVID_19_mRNA_vaccine_protects_against_SARS_CoV_2_Omicron_BA_1_infection_in_diet_induced_obese_mice_through_boosting_host_innate_antiviral_responses_
DB - PRIME
DP - Unbound Medicine
ER -
