Tags

Type your tag names separated by a space and hit enter

Expanding cerebellar lacunes due to dilatation of the perivascular space associated with Binswanger's subcortical arteriosclerotic encephalopathy.
Stroke. 1987 Nov-Dec; 18(6):1087-92.S

Abstract

An 80-year-old hypertensive woman developed right hemiplegia and died 24 hours after admission. Neuropathologic examination revealed multiple cerebral infarcts of various ages and diffuse subcortical arteriosclerotic encephalopathy. Clusters of asymptomatic "expanding" lacunes, due to dilatation of the perivascular spaces, were found in both dentate nuclei. These cavities, which presented as space-occupying lesions, were surrounded by a single layer of flattened cells and contained 1 or more sections of normal-looking arterioles. Such a topographic grouping of lacunes in the dentate nucleus has not been described previously. The mechanism of widening of the perivascular compartment remains unclear; its occurrence in a hypertensive patient and its association with typical Binswanger's subcortical arteriosclerotic encephalopathy and severe atherosclerosis with multiple infarcts suggest a common pathophysiologic mechanism possibly including an alteration of the blood-brain barrier.

Authors+Show Affiliations

Département d'Histologie-Embryologie-Biologie cellulaire, Faculté de Médecine Paris-Val de Marne, Hôpital Henri Mondor, Créteil, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

3686582

Citation

Benhaïem-Sigaux, N, et al. "Expanding Cerebellar Lacunes Due to Dilatation of the Perivascular Space Associated With Binswanger's Subcortical Arteriosclerotic Encephalopathy." Stroke, vol. 18, no. 6, 1987, pp. 1087-92.
Benhaïem-Sigaux N, Gray F, Gherardi R, et al. Expanding cerebellar lacunes due to dilatation of the perivascular space associated with Binswanger's subcortical arteriosclerotic encephalopathy. Stroke. 1987;18(6):1087-92.
Benhaïem-Sigaux, N., Gray, F., Gherardi, R., Roucayrol, A. M., & Poirier, J. (1987). Expanding cerebellar lacunes due to dilatation of the perivascular space associated with Binswanger's subcortical arteriosclerotic encephalopathy. Stroke, 18(6), 1087-92.
Benhaïem-Sigaux N, et al. Expanding Cerebellar Lacunes Due to Dilatation of the Perivascular Space Associated With Binswanger's Subcortical Arteriosclerotic Encephalopathy. Stroke. 1987 Nov-Dec;18(6):1087-92. PubMed PMID: 3686582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expanding cerebellar lacunes due to dilatation of the perivascular space associated with Binswanger's subcortical arteriosclerotic encephalopathy. AU - Benhaïem-Sigaux,N, AU - Gray,F, AU - Gherardi,R, AU - Roucayrol,A M, AU - Poirier,J, PY - 1987/11/1/pubmed PY - 1987/11/1/medline PY - 1987/11/1/entrez SP - 1087 EP - 92 JF - Stroke JO - Stroke VL - 18 IS - 6 N2 - An 80-year-old hypertensive woman developed right hemiplegia and died 24 hours after admission. Neuropathologic examination revealed multiple cerebral infarcts of various ages and diffuse subcortical arteriosclerotic encephalopathy. Clusters of asymptomatic "expanding" lacunes, due to dilatation of the perivascular spaces, were found in both dentate nuclei. These cavities, which presented as space-occupying lesions, were surrounded by a single layer of flattened cells and contained 1 or more sections of normal-looking arterioles. Such a topographic grouping of lacunes in the dentate nucleus has not been described previously. The mechanism of widening of the perivascular compartment remains unclear; its occurrence in a hypertensive patient and its association with typical Binswanger's subcortical arteriosclerotic encephalopathy and severe atherosclerosis with multiple infarcts suggest a common pathophysiologic mechanism possibly including an alteration of the blood-brain barrier. SN - 0039-2499 UR - https://www.unboundmedicine.com/medline/citation/3686582/Expanding_cerebellar_lacunes_due_to_dilatation_of_the_perivascular_space_associated_with_Binswanger's_subcortical_arteriosclerotic_encephalopathy_ L2 - https://www.ahajournals.org/doi/10.1161/01.str.18.6.1087?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -