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Serum and bile lipids in young women with radiolucent gallstones.
Am J Gastroenterol 1987; 82(12):1279-82AJ

Abstract

To investigate the relationship between blood and bile lipids, serum cholesterol, high density lipoprotein cholesterol, and triglycerides were correlated with cholesterol saturation index of bile in 21 women-10 with radiolucent gallstones and 11 without stones. All of the women had regular menstrual cycles, were normolipidemic, and on a hospital diet. On the same morning, blood and the darkest duodenal bile were taken after cholecystokinin (CCK) stimulation. Standard laboratory procedures were used to analyze serum and bile lipids. We found: 1) statistically significant (t test, p less than 0.05) but only slight hypercholesterolemia (+ 12%) in patients with gallstones; 2) a negative correlation of serum cholesterol with cholesterol saturation index of bile, both in the control group (r = -0.654, p less than 0.05) and in gallstone patients (r = -0.665, p less than 0.05); 3) a correlation of high density lipoprotein cholesterol with cholesterol saturation index only in normal women (r = -0.619, p less than 0.05); 4) conversely, a correlation of triglycerides with the same index in only gallstone patients (r = 0.641, p less than 0.05). With the stepwise multiple regression analysis (independent variables: diagnosis of gallstones, serum cholesterol, HDL cholesterol, triglycerides; dependent variable: biliary cholesterol saturation index), only gallstone diagnosis and serum cholesterol influenced significantly (F test, p less than 0.05) the biliary cholesterol saturation index. These findings suggest that young women with radiolucent gallstones are slightly hypercholesterolemic, that in women both with and without gallstones there is a negative correlation between serum cholesterol and biliary cholesterol saturation, but women with gallstones have a higher cholesterol saturation index of the bile than women without gallstones with the same level of cholesterol in the blood.

Authors+Show Affiliations

Laboratorio di Fisipatologia Digestiva, Istituto di Ricovero e Cura a Carattere Scientifico Castellana G, (Bari), Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3687905

Citation

Cavallini, A, et al. "Serum and Bile Lipids in Young Women With Radiolucent Gallstones." The American Journal of Gastroenterology, vol. 82, no. 12, 1987, pp. 1279-82.
Cavallini A, Messa C, Mangini V, et al. Serum and bile lipids in young women with radiolucent gallstones. Am J Gastroenterol. 1987;82(12):1279-82.
Cavallini, A., Messa, C., Mangini, V., Argese, V., Misciagna, G., & Giorgio, I. (1987). Serum and bile lipids in young women with radiolucent gallstones. The American Journal of Gastroenterology, 82(12), pp. 1279-82.
Cavallini A, et al. Serum and Bile Lipids in Young Women With Radiolucent Gallstones. Am J Gastroenterol. 1987;82(12):1279-82. PubMed PMID: 3687905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum and bile lipids in young women with radiolucent gallstones. AU - Cavallini,A, AU - Messa,C, AU - Mangini,V, AU - Argese,V, AU - Misciagna,G, AU - Giorgio,I, PY - 1987/12/1/pubmed PY - 1987/12/1/medline PY - 1987/12/1/entrez SP - 1279 EP - 82 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 82 IS - 12 N2 - To investigate the relationship between blood and bile lipids, serum cholesterol, high density lipoprotein cholesterol, and triglycerides were correlated with cholesterol saturation index of bile in 21 women-10 with radiolucent gallstones and 11 without stones. All of the women had regular menstrual cycles, were normolipidemic, and on a hospital diet. On the same morning, blood and the darkest duodenal bile were taken after cholecystokinin (CCK) stimulation. Standard laboratory procedures were used to analyze serum and bile lipids. We found: 1) statistically significant (t test, p less than 0.05) but only slight hypercholesterolemia (+ 12%) in patients with gallstones; 2) a negative correlation of serum cholesterol with cholesterol saturation index of bile, both in the control group (r = -0.654, p less than 0.05) and in gallstone patients (r = -0.665, p less than 0.05); 3) a correlation of high density lipoprotein cholesterol with cholesterol saturation index only in normal women (r = -0.619, p less than 0.05); 4) conversely, a correlation of triglycerides with the same index in only gallstone patients (r = 0.641, p less than 0.05). With the stepwise multiple regression analysis (independent variables: diagnosis of gallstones, serum cholesterol, HDL cholesterol, triglycerides; dependent variable: biliary cholesterol saturation index), only gallstone diagnosis and serum cholesterol influenced significantly (F test, p less than 0.05) the biliary cholesterol saturation index. These findings suggest that young women with radiolucent gallstones are slightly hypercholesterolemic, that in women both with and without gallstones there is a negative correlation between serum cholesterol and biliary cholesterol saturation, but women with gallstones have a higher cholesterol saturation index of the bile than women without gallstones with the same level of cholesterol in the blood. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/3687905/Serum_and_bile_lipids_in_young_women_with_radiolucent_gallstones_ L2 - https://medlineplus.gov/gallstones.html DB - PRIME DP - Unbound Medicine ER -