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Fractal dynamics of individual mitochondrial oscillators measure local inter-mitochondrial coupling.
Biophys J. 2023 Apr 18; 122(8):1459-1469.BJ

Abstract

Mitochondrial inner membrane potentials in cardiomyocytes may oscillate in cycles of depolarization/repolarization when the mitochondrial network is exposed to metabolic or oxidative stress. The frequencies of such oscillations are dynamically changing while clusters of weakly coupled mitochondrial oscillators adjust to a common phase and frequency. Across the cardiac myocyte, the averaged signal of the mitochondrial population follows self-similar or fractal dynamics; however, fractal properties of individual mitochondrial oscillators have not yet been examined. We show that the largest synchronously oscillating cluster exhibits a fractal dimension, D, that is indicative of self-similar behavior with D=1.27±0.11, in contrast to the remaining network mitochondria whose fractal dimension is close to that of Brownian noise, D=1.58±0.10. We further demonstrate that fractal behavior is correlated with local coupling mechanisms, whereas it is only weakly linked to measures of functional connections between mitochondria. Our findings suggest that individual mitochondrial fractal dimensions may serve as a simple measure of local mitochondrial coupling.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Kurz FT
German Cancer Research Center, Division of Radiology, Heidelberg, Germany; Massachusetts General Hospital, Cardiovascular Research Center, Harvard Medical School, Charlestown, Massachusetts. Electronic address: f.kurz@dkfz-heidelberg.de.
Aon MA
Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Schlemmer HP
German Cancer Research Center, Division of Radiology, Heidelberg, Germany.
Jende JME
Heidelberg University Hospital, Department of Neuroradiology, Heidelberg, Germany.
O'Rourke B
Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, Maryland.
Armoundas AA
Massachusetts General Hospital, Cardiovascular Research Center, Harvard Medical School, Charlestown, Massachusetts; Broad Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts. Electronic address: armoundas.antonis@mgh.harvard.edu.

MeSH

FractalsMitochondriaOxidative StressMembrane Potential, MitochondrialMitochondrial Membranes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

36905121

Citation

Kurz, Felix T., et al. "Fractal Dynamics of Individual Mitochondrial Oscillators Measure Local Inter-mitochondrial Coupling." Biophysical Journal, vol. 122, no. 8, 2023, pp. 1459-1469.
Kurz FT, Aon MA, Schlemmer HP, et al. Fractal dynamics of individual mitochondrial oscillators measure local inter-mitochondrial coupling. Biophys J. 2023;122(8):1459-1469.
Kurz, F. T., Aon, M. A., Schlemmer, H. P., Jende, J. M. E., O'Rourke, B., & Armoundas, A. A. (2023). Fractal dynamics of individual mitochondrial oscillators measure local inter-mitochondrial coupling. Biophysical Journal, 122(8), 1459-1469. https://doi.org/10.1016/j.bpj.2023.03.011
Kurz FT, et al. Fractal Dynamics of Individual Mitochondrial Oscillators Measure Local Inter-mitochondrial Coupling. Biophys J. 2023 Apr 18;122(8):1459-1469. PubMed PMID: 36905121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fractal dynamics of individual mitochondrial oscillators measure local inter-mitochondrial coupling. AU - Kurz,Felix T, AU - Aon,Miguel A, AU - Schlemmer,Heinz-Peter, AU - Jende,Johann M E, AU - O'Rourke,Brian, AU - Armoundas,Antonis A, Y1 - 2023/03/10/ PY - 2022/2/17/received PY - 2022/9/29/revised PY - 2023/3/6/accepted PY - 2024/4/18/pmc-release PY - 2023/4/21/medline PY - 2023/3/12/pubmed PY - 2023/3/11/entrez SP - 1459 EP - 1469 JF - Biophysical journal JO - Biophys J VL - 122 IS - 8 N2 - Mitochondrial inner membrane potentials in cardiomyocytes may oscillate in cycles of depolarization/repolarization when the mitochondrial network is exposed to metabolic or oxidative stress. The frequencies of such oscillations are dynamically changing while clusters of weakly coupled mitochondrial oscillators adjust to a common phase and frequency. Across the cardiac myocyte, the averaged signal of the mitochondrial population follows self-similar or fractal dynamics; however, fractal properties of individual mitochondrial oscillators have not yet been examined. We show that the largest synchronously oscillating cluster exhibits a fractal dimension, D, that is indicative of self-similar behavior with D=1.27±0.11, in contrast to the remaining network mitochondria whose fractal dimension is close to that of Brownian noise, D=1.58±0.10. We further demonstrate that fractal behavior is correlated with local coupling mechanisms, whereas it is only weakly linked to measures of functional connections between mitochondria. Our findings suggest that individual mitochondrial fractal dimensions may serve as a simple measure of local mitochondrial coupling. SN - 1542-0086 UR - https://www.unboundmedicine.com/medline/citation/36905121/Fractal_dynamics_of_individual_mitochondrial_oscillators_measure_local_inter_mitochondrial_coupling_ DB - PRIME DP - Unbound Medicine ER -