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Vitamin B12 homoeostasis after haemorrhage in the rat: the importance of skeletal muscle.
Clin Sci (Lond). 1987 Dec; 73(6):581-7.CS

Abstract

1. The effects of haemorrhage on vitamin B12 (cobalamin) homoeostasis have been studied in rats with and without prior administration of 57Co-labelled cyanocobalamin. 2. Arteriovenous differences in radioactivity and endogenous B12 were measured across the thigh extensor muscles. Radioactivity and endogenous B12 were also measured in skeletal muscle, liver and kidney. 3. Haemorrhage induced a marked rise in circulating B12 with a concomitant loss of the vitamin from skeletal muscle and liver, but in kidney there was a net gain. Restoration of the blood volume with autologous plasma did not prevent release of B12 from tissues. 4. The results suggest that vitamin B12 reserves may be seriously depleted by the wasting of skeletal muscle.

Authors+Show Affiliations

Bhatt HR
Children's Medical Charity Research Unit, Department of Child Health, Westminister Children's Hospital, Charing Cross and Westminister Medical School, London.
Linnell JC
No affiliation info available

MeSH

AnimalsArteriesHemorrhageHomeostasisKidneyLiverMaleMusclesRatsRats, Inbred StrainsVeinsVitamin B 12

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3690974

Citation

Bhatt, H R., and J C. Linnell. "Vitamin B12 Homoeostasis After Haemorrhage in the Rat: the Importance of Skeletal Muscle." Clinical Science (London, England : 1979), vol. 73, no. 6, 1987, pp. 581-7.
Bhatt HR, Linnell JC. Vitamin B12 homoeostasis after haemorrhage in the rat: the importance of skeletal muscle. Clin Sci (Lond). 1987;73(6):581-7.
Bhatt, H. R., & Linnell, J. C. (1987). Vitamin B12 homoeostasis after haemorrhage in the rat: the importance of skeletal muscle. Clinical Science (London, England : 1979), 73(6), 581-7.
Bhatt HR, Linnell JC. Vitamin B12 Homoeostasis After Haemorrhage in the Rat: the Importance of Skeletal Muscle. Clin Sci (Lond). 1987;73(6):581-7. PubMed PMID: 3690974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin B12 homoeostasis after haemorrhage in the rat: the importance of skeletal muscle. AU - Bhatt,H R, AU - Linnell,J C, PY - 1987/12/1/pubmed PY - 1987/12/1/medline PY - 1987/12/1/entrez SP - 581 EP - 7 JF - Clinical science (London, England : 1979) JO - Clin Sci (Lond) VL - 73 IS - 6 N2 - 1. The effects of haemorrhage on vitamin B12 (cobalamin) homoeostasis have been studied in rats with and without prior administration of 57Co-labelled cyanocobalamin. 2. Arteriovenous differences in radioactivity and endogenous B12 were measured across the thigh extensor muscles. Radioactivity and endogenous B12 were also measured in skeletal muscle, liver and kidney. 3. Haemorrhage induced a marked rise in circulating B12 with a concomitant loss of the vitamin from skeletal muscle and liver, but in kidney there was a net gain. Restoration of the blood volume with autologous plasma did not prevent release of B12 from tissues. 4. The results suggest that vitamin B12 reserves may be seriously depleted by the wasting of skeletal muscle. SN - 0143-5221 UR - https://www.unboundmedicine.com/medline/citation/3690974/Vitamin_B12_homoeostasis_after_haemorrhage_in_the_rat:_the_importance_of_skeletal_muscle_ DB - PRIME DP - Unbound Medicine ER -