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Effects of omega-3 supplementation on glucose and lipid metabolism in patients with gestational diabetes: A meta-analysis of randomized controlled trials.
J Diabetes Complications. 2023 04; 37(4):108451.JD

Abstract

AIM

We assessed whether omega-3 supplementation could improve glucose and lipid metabolism, insulin resistance, and inflammatory factors in individuals with gestational diabetes mellitus (GDM).

METHODS

In this meta-study, we used a random-effects or fixed-effects meta-analysis model to analyze the mean differences (MD) and corresponding 95 % confidence intervals (CI) before and after omega-3 and placebo supplementation, thus evaluating the effects of omega-3 on glucose and lipid metabolism, insulin resistance, and inflammatory factors.

RESULTS

Six randomized controlled trials (331 participants) were included in the meta-analysis. The levels of fasting plasma glucose (FPG) (WMD = -0.25 mmol/L; 95 % CI: -0.38, -0.12), fasting insulin (WMD = -17.13 pmol/L; 95 % CI: -27.95, -6.30), and homeostasis model of assessment-insulin resistance (WMD = -0.51; 95 % CI: -0.89, -0.12) were lower in the omega-3 group compared to their levels in the placebo group. The results of the analysis of lipid metabolism showed that triglycerides (WMD = -0.18 mmol/L; 95 % CI: -0.29, -0.08) and very low-density lipoprotein cholesterol (WMD = -0.1 mmol/L; 95 % CI: -0.16, -0.03) decreased in the omega-3 group, while high-density lipoproteins (WMD = 0.06 mmol/L; 95 % CI: 0.02, 0.10) increased. Compared to the placebo group, inflammatory factor serum C-reactive protein (SMD = -0.68 mmol/L; 95 % CI: -0.96, -0.39) decreased in the omega-3 group.

CONCLUSION

Omega-3 supplementation can decrease the levels of FPG and inflammatory factors, enhance blood lipid metabolism, and reduce insulin resistance in patients with GDM.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Liu W
Department of Endocrinology and Metabolism, First Hospital of Jilin University, 1 Xinmin Street, Changchun 130021, Jilin, China.
Gao M
Department of Endocrinology and Metabolism, First Hospital of Jilin University, 1 Xinmin Street, Changchun 130021, Jilin, China.
Yang S
Department of Clinical Nutrition, First Hospital of Jilin University, 1 Xinmin Street, Changchun 130021, Jilin, China.
Sun C
Department of Endocrinology and Metabolism, First Hospital of Jilin University, 1 Xinmin Street, Changchun 130021, Jilin, China; Department of Clinical Nutrition, First Hospital of Jilin University, 1 Xinmin Street, Changchun 130021, Jilin, China.
Bi Y
Department of Endocrinology and Metabolism, First Hospital of Jilin University, 1 Xinmin Street, Changchun 130021, Jilin, China.
Li Y
Department of Endocrinology and Metabolism, First Hospital of Jilin University, 1 Xinmin Street, Changchun 130021, Jilin, China.
Wang J
Department of Clinical Nutrition, First Hospital of Jilin University, 1 Xinmin Street, Changchun 130021, Jilin, China. Electronic address: jpwang08@mails.jlu.edu.cn.
Yuan X
Department of Clinical Nutrition, First Hospital of Jilin University, 1 Xinmin Street, Changchun 130021, Jilin, China. Electronic address: yuanxj2000@jlu.edu.cn.

MeSH

PregnancyFemaleHumansDiabetes, GestationalInsulin ResistanceGlucoseBlood GlucoseLipid MetabolismDietary SupplementsRandomized Controlled Trials as TopicFatty Acids, Omega-3

Pub Type(s)

Meta-Analysis
Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

36913875

Citation

Liu, Weixia, et al. "Effects of Omega-3 Supplementation On Glucose and Lipid Metabolism in Patients With Gestational Diabetes: a Meta-analysis of Randomized Controlled Trials." Journal of Diabetes and Its Complications, vol. 37, no. 4, 2023, p. 108451.
Liu W, Gao M, Yang S, et al. Effects of omega-3 supplementation on glucose and lipid metabolism in patients with gestational diabetes: A meta-analysis of randomized controlled trials. J Diabetes Complications. 2023;37(4):108451.
Liu, W., Gao, M., Yang, S., Sun, C., Bi, Y., Li, Y., Wang, J., & Yuan, X. (2023). Effects of omega-3 supplementation on glucose and lipid metabolism in patients with gestational diabetes: A meta-analysis of randomized controlled trials. Journal of Diabetes and Its Complications, 37(4), 108451. https://doi.org/10.1016/j.jdiacomp.2023.108451
Liu W, et al. Effects of Omega-3 Supplementation On Glucose and Lipid Metabolism in Patients With Gestational Diabetes: a Meta-analysis of Randomized Controlled Trials. J Diabetes Complications. 2023;37(4):108451. PubMed PMID: 36913875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of omega-3 supplementation on glucose and lipid metabolism in patients with gestational diabetes: A meta-analysis of randomized controlled trials. AU - Liu,Weixia, AU - Gao,Menghan, AU - Yang,Shuo, AU - Sun,Chenglin, AU - Bi,Yaru, AU - Li,Yuting, AU - Wang,Jiping, AU - Yuan,Xiaojie, Y1 - 2023/03/07/ PY - 2022/10/21/received PY - 2023/03/01/revised PY - 2023/03/03/accepted PY - 2023/3/14/pubmed PY - 2023/3/22/medline PY - 2023/3/13/entrez KW - Gestational diabetes KW - Glucose metabolism KW - Insulin resistance KW - Lipid metabolism KW - Omega-3 fatty acids KW - meta-analysis SP - 108451 EP - 108451 JF - Journal of diabetes and its complications JO - J Diabetes Complications VL - 37 IS - 4 N2 - AIM: We assessed whether omega-3 supplementation could improve glucose and lipid metabolism, insulin resistance, and inflammatory factors in individuals with gestational diabetes mellitus (GDM). METHODS: In this meta-study, we used a random-effects or fixed-effects meta-analysis model to analyze the mean differences (MD) and corresponding 95 % confidence intervals (CI) before and after omega-3 and placebo supplementation, thus evaluating the effects of omega-3 on glucose and lipid metabolism, insulin resistance, and inflammatory factors. RESULTS: Six randomized controlled trials (331 participants) were included in the meta-analysis. The levels of fasting plasma glucose (FPG) (WMD = -0.25 mmol/L; 95 % CI: -0.38, -0.12), fasting insulin (WMD = -17.13 pmol/L; 95 % CI: -27.95, -6.30), and homeostasis model of assessment-insulin resistance (WMD = -0.51; 95 % CI: -0.89, -0.12) were lower in the omega-3 group compared to their levels in the placebo group. The results of the analysis of lipid metabolism showed that triglycerides (WMD = -0.18 mmol/L; 95 % CI: -0.29, -0.08) and very low-density lipoprotein cholesterol (WMD = -0.1 mmol/L; 95 % CI: -0.16, -0.03) decreased in the omega-3 group, while high-density lipoproteins (WMD = 0.06 mmol/L; 95 % CI: 0.02, 0.10) increased. Compared to the placebo group, inflammatory factor serum C-reactive protein (SMD = -0.68 mmol/L; 95 % CI: -0.96, -0.39) decreased in the omega-3 group. CONCLUSION: Omega-3 supplementation can decrease the levels of FPG and inflammatory factors, enhance blood lipid metabolism, and reduce insulin resistance in patients with GDM. SN - 1873-460X UR - https://www.unboundmedicine.com/medline/citation/36913875/Effects_of_omega_3_supplementation_on_glucose_and_lipid_metabolism_in_patients_with_gestational_diabetes:_A_meta_analysis_of_randomized_controlled_trials_ DB - PRIME DP - Unbound Medicine ER -

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