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Pseudotyped Viruses for Coronaviruses.
Adv Exp Med Biol. 2023; 1407:133-151.AE

Abstract

Seven coronaviruses have been identified that can infect humans, four of which usually cause mild symptoms, including HCoV-229E, HCoV-NL63, HCoV-OC43, and HCoV-HKU1, three of which are lethal coronaviruses, named severe acute respiratory syndrome coronavirus, Middle East respiratory syndrome coronavirus, and severe acute respiratory syndrome coronavirus 2. Pseudotyped virus is an important tool in the field of human coronavirus research because it is safe, easy to prepare, easy to detect, and highly modifiable. In addition to the application of pseudotyped viruses in the study of virus infection mechanism, vaccine, and candidate antiviral drug or antibody evaluation and screening, pseudotyped viruses can also be used as an important platform for further application in the prediction of immunogenicity and antigenicity after virus mutation, cross-species transmission prediction, screening, and preparation of vaccine strains with better broad spectrum and antigenicity. Meanwhile, as clinical trials of various types of vaccines and post-clinical studies are also being carried out one after another, the establishment of a high-throughput and fully automated detection platform based on SARS-CoV-2 pseudotyped virus to further reduce the cost of detection and manual intervention and improve the efficiency of large-scale detection is also a demand for the development of SARS-CoV-2 pseudotyped virus.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Wang M
Division of HIV/AIDS and Sex-transmitted Virus Vaccines, National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals, Beijing, China. Units Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic and Technology of China, Chengdu, China.
Nie J
Units Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic and Technology of China, Chengdu, China.
Wang Y
Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. wangyc@nifdc.org.cn. Institute of Medical Biology, Chinese Academy of Medicine Sciences & Peking Union Medical College, Kunming, China. wangyc@nifdc.org.cn.

MeSH

HumansViral PseudotypingCOVID-19SARS-CoV-2Middle East Respiratory Syndrome CoronavirusCoronavirus 229E, Human

Pub Type(s)

Journal Article

Language

eng

PubMed ID

36920695

Citation

Wang, Meiyu, et al. "Pseudotyped Viruses for Coronaviruses." Advances in Experimental Medicine and Biology, vol. 1407, 2023, pp. 133-151.
Wang M, Nie J, Wang Y. Pseudotyped Viruses for Coronaviruses. Adv Exp Med Biol. 2023;1407:133-151.
Wang, M., Nie, J., & Wang, Y. (2023). Pseudotyped Viruses for Coronaviruses. Advances in Experimental Medicine and Biology, 1407, 133-151. https://doi.org/10.1007/978-981-99-0113-5_7
Wang M, Nie J, Wang Y. Pseudotyped Viruses for Coronaviruses. Adv Exp Med Biol. 2023;1407:133-151. PubMed PMID: 36920695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pseudotyped Viruses for Coronaviruses. AU - Wang,Meiyu, AU - Nie,Jianhui, AU - Wang,Youchun, PY - 2023/3/15/entrez PY - 2023/3/16/pubmed PY - 2023/3/16/medline KW - MERS-CoV KW - Monoclonal antibodies KW - Neutralization assay KW - Pseudotyped virus KW - SARS-CoV KW - SARS-CoV-2 KW - Vaccine SP - 133 EP - 151 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 1407 N2 - Seven coronaviruses have been identified that can infect humans, four of which usually cause mild symptoms, including HCoV-229E, HCoV-NL63, HCoV-OC43, and HCoV-HKU1, three of which are lethal coronaviruses, named severe acute respiratory syndrome coronavirus, Middle East respiratory syndrome coronavirus, and severe acute respiratory syndrome coronavirus 2. Pseudotyped virus is an important tool in the field of human coronavirus research because it is safe, easy to prepare, easy to detect, and highly modifiable. In addition to the application of pseudotyped viruses in the study of virus infection mechanism, vaccine, and candidate antiviral drug or antibody evaluation and screening, pseudotyped viruses can also be used as an important platform for further application in the prediction of immunogenicity and antigenicity after virus mutation, cross-species transmission prediction, screening, and preparation of vaccine strains with better broad spectrum and antigenicity. Meanwhile, as clinical trials of various types of vaccines and post-clinical studies are also being carried out one after another, the establishment of a high-throughput and fully automated detection platform based on SARS-CoV-2 pseudotyped virus to further reduce the cost of detection and manual intervention and improve the efficiency of large-scale detection is also a demand for the development of SARS-CoV-2 pseudotyped virus. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/36920695/Pseudotyped_Viruses_for_Coronaviruses_ DB - PRIME DP - Unbound Medicine ER -