Citation
Barateau, Véronique, et al. "Prior SARS-CoV-2 Infection Enhances and Reshapes Spike Protein-specific Memory Induced By Vaccination." Science Translational Medicine, vol. 15, no. 687, 2023, pp. eade0550.
Barateau V, Peyrot L, Saade C, et al. Prior SARS-CoV-2 infection enhances and reshapes spike protein-specific memory induced by vaccination. Sci Transl Med. 2023;15(687):eade0550.
Barateau, V., Peyrot, L., Saade, C., Pozzetto, B., Brengel-Pesce, K., Elsensohn, M. H., Allatif, O., Guibert, N., Compagnon, C., Mariano, N., Chaix, J., Djebali, S., Fassier, J. B., Lina, B., Lefsihane, K., Espi, M., Thaunat, O., Marvel, J., Rosa-Calatrava, M., ... Defrance, T. (2023). Prior SARS-CoV-2 infection enhances and reshapes spike protein-specific memory induced by vaccination. Science Translational Medicine, 15(687), eade0550. https://doi.org/10.1126/scitranslmed.ade0550
Barateau V, et al. Prior SARS-CoV-2 Infection Enhances and Reshapes Spike Protein-specific Memory Induced By Vaccination. Sci Transl Med. 2023 Mar 15;15(687):eade0550. PubMed PMID: 36921035.
TY - JOUR
T1 - Prior SARS-CoV-2 infection enhances and reshapes spike protein-specific memory induced by vaccination.
AU - Barateau,Véronique,
AU - Peyrot,Loïc,
AU - Saade,Carla,
AU - Pozzetto,Bruno,
AU - Brengel-Pesce,Karen,
AU - Elsensohn,Mad-Hélénie,
AU - Allatif,Omran,
AU - Guibert,Nicolas,
AU - Compagnon,Christelle,
AU - Mariano,Natacha,
AU - Chaix,Julie,
AU - Djebali,Sophia,
AU - Fassier,Jean-Baptiste,
AU - Lina,Bruno,
AU - Lefsihane,Katia,
AU - Espi,Maxime,
AU - Thaunat,Olivier,
AU - Marvel,Jacqueline,
AU - Rosa-Calatrava,Manuel,
AU - Pizzorno,Andres,
AU - Maucort-Boulch,Delphine,
AU - Henaff,Laetitia,
AU - Saadatian-Elahi,Mitra,
AU - Vanhems,Philippe,
AU - Paul,Stéphane,
AU - Walzer,Thierry,
AU - Trouillet-Assant,Sophie,
AU - Defrance,Thierry,
Y1 - 2023/03/15/
PY - 2023/3/15/entrez
PY - 2023/3/16/pubmed
PY - 2023/3/21/medline
SP - eade0550
EP - eade0550
JF - Science translational medicine
JO - Sci Transl Med
VL - 15
IS - 687
N2 - The diversity of vaccination modalities and infection history are both variables that have an impact on the immune memory of individuals vaccinated against SARS-CoV-2. To gain more accurate knowledge of how these parameters imprint on immune memory, we conducted a long-term follow-up of SARS-CoV-2 spike protein-specific immune memory in unvaccinated and vaccinated COVID-19 convalescent individuals as well as in infection-naïve vaccinated individuals. Here, we report that individuals from the convalescent vaccinated (hybrid immunity) group have the highest concentrations of spike protein-specific antibodies at 6 months after vaccination. As compared with infection-naïve vaccinated individuals, they also display increased frequencies of an atypical mucosa-targeted memory B cell subset. These individuals also exhibited enhanced TH1 polarization of their SARS-CoV-2 spike protein-specific follicular T helper cell pool. Together, our data suggest that prior SARS-CoV-2 infection increases the titers of SARS-CoV-2 spike protein-specific antibody responses elicited by subsequent vaccination and induces modifications in the composition of the spike protein-specific memory B cell pool that are compatible with enhanced functional protection at mucosal sites.
SN - 1946-6242
UR - https://www.unboundmedicine.com/medline/citation/36921035/Prior_SARS_CoV_2_infection_enhances_and_reshapes_spike_protein_specific_memory_induced_by_vaccination_
DB - PRIME
DP - Unbound Medicine
ER -
