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A Case of Acute Generalized Exanthematous Pustulosis Induced by Ceftriaxone.
Cureus. 2023 Mar; 15(3):e36281.C

Abstract

Acute generalized exanthematous pustulosis (AGEP) is a rare and severe skin disorder induced in more than 90% of cases by an adverse drug reaction. This condition is defined by an acute growth of numerous, pin-head-sized, non-follicular pustules on a background of edematous erythema that starts on the face or in the armpits and groin. It is accompanied by fever and increased inflammatory markers. We present a case of a 39-year-old male, admitted to the internal medicine department due to Streptococcus pneumoniae meningitis treated with ceftriaxone, who developed erythema covered with small sterile pustules in the face, neck, and axilla four days after antibiotic treatment. The clinical and pathological correlations confirmed the diagnosis, and the dermatosis resolved after discontinuing the drug and systemic corticosteroid treatment. Early recognition of this drug-induced dermatosis is crucial for adequate treatment.

Authors+Show Affiliations

Internal Medicine, Hospital Distrital de Santarém, Santarém, PRT.Internal Medicine, Hospital Distrital de Santarém, Santarém, PRT.Internal Medicine, Hospital Distrital de Santarém, Santarém, PRT.Internal Medicine, Hospital Distrital de Santarém, Santarém, PRT.Internal Medicine, Hospital Distrital de Santarém, Santarém, PRT.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

36937126

Citation

Santos, Maria Inês, et al. "A Case of Acute Generalized Exanthematous Pustulosis Induced By Ceftriaxone." Cureus, vol. 15, no. 3, 2023, pp. e36281.
Santos MI, Sousa M, Cerqueira P, et al. A Case of Acute Generalized Exanthematous Pustulosis Induced by Ceftriaxone. Cureus. 2023;15(3):e36281.
Santos, M. I., Sousa, M., Cerqueira, P., Ambrioso, I., & Moniz Ramos, M. (2023). A Case of Acute Generalized Exanthematous Pustulosis Induced by Ceftriaxone. Cureus, 15(3), e36281. https://doi.org/10.7759/cureus.36281
Santos MI, et al. A Case of Acute Generalized Exanthematous Pustulosis Induced By Ceftriaxone. Cureus. 2023;15(3):e36281. PubMed PMID: 36937126.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Case of Acute Generalized Exanthematous Pustulosis Induced by Ceftriaxone. AU - Santos,Maria Inês, AU - Sousa,Mafalda, AU - Cerqueira,Paula, AU - Ambrioso,Inês, AU - Moniz Ramos,Mariana, Y1 - 2023/03/17/ PY - 2023/02/28/accepted PY - 2023/3/20/entrez PY - 2023/3/21/pubmed PY - 2023/3/21/medline KW - acute generalized erythematous pustulosis KW - ceftriaxone KW - corticoisteroids KW - dermatosis KW - erythema SP - e36281 EP - e36281 JF - Cureus JO - Cureus VL - 15 IS - 3 N2 - Acute generalized exanthematous pustulosis (AGEP) is a rare and severe skin disorder induced in more than 90% of cases by an adverse drug reaction. This condition is defined by an acute growth of numerous, pin-head-sized, non-follicular pustules on a background of edematous erythema that starts on the face or in the armpits and groin. It is accompanied by fever and increased inflammatory markers. We present a case of a 39-year-old male, admitted to the internal medicine department due to Streptococcus pneumoniae meningitis treated with ceftriaxone, who developed erythema covered with small sterile pustules in the face, neck, and axilla four days after antibiotic treatment. The clinical and pathological correlations confirmed the diagnosis, and the dermatosis resolved after discontinuing the drug and systemic corticosteroid treatment. Early recognition of this drug-induced dermatosis is crucial for adequate treatment. SN - 2168-8184 UR - https://www.unboundmedicine.com/medline/citation/36937126/A_Case_of_Acute_Generalized_Exanthematous_Pustulosis_Induced_by_Ceftriaxone_ DB - PRIME DP - Unbound Medicine ER -
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