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Excessively Increased Skeletal Muscle Mass of the Bilateral Lower Limbs is Associated with Hyperuricemia in Females with Polycystic Ovarian Syndrome.
Reprod Sci. 2023 Mar 21 [Online ahead of print]RS

Abstract

This study is aimed at evaluating the correlation between the skeletal muscle mass index (SMI) of different body parts and hyperuricemia in females with polycystic ovary syndrome (PCOS), thus, providing scientific guidance on lifestyle self-management for patients with PCOS. The cross-sectional study included 171 patients with PCOS, which were divided into two distinct sub-groups based on the presence or absence of hyperuricemia. Anthropometric and serological characteristics of the population with PCOS focusing on skeletal muscle mass were conducted. PCOS patients with hyperuricemia had significantly greater SMI in different body parts. Further binary logistic regression analysis revealed that SMI of the bilateral lower limbs was positively associated with hyperuricemia with an adjusted odds ratio (95% confidence interval) of 1.235 (1.103 - 1.384), p < 0.001. The optimal cut-off value of SMI of the bilateral lower limbs in predicting hyperuricemia was 5.11 (Youden index = 0.490). Combined with the mean value of SMI in the bilateral upper limbs, the safe range of SMI of the bilateral lower limbs in patients with PCOS was calculated as 3.64 - 5.11, with the sensitivity and negative predictive values being 83.9% and 65.1%, respectively. Excessively increased SMI of the bilateral lower limbs was correlated with hyperuricemia in patients with PCOS.

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Authors+Show Affiliations

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, He Ping District, Tianjin, People's Republic of China.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, He Ping District, Tianjin, People's Republic of China.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, He Ping District, Tianjin, People's Republic of China.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, He Ping District, Tianjin, People's Republic of China.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, He Ping District, Tianjin, People's Republic of China.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, He Ping District, Tianjin, People's Republic of China. tianwenyan1108@163.com.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, He Ping District, Tianjin, People's Republic of China. huiying_zhang2020@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

36944907

Citation

Li, Xiaoyan, et al. "Excessively Increased Skeletal Muscle Mass of the Bilateral Lower Limbs Is Associated With Hyperuricemia in Females With Polycystic Ovarian Syndrome." Reproductive Sciences (Thousand Oaks, Calif.), 2023.

Li X, Wu W, Li X, et al. Excessively Increased Skeletal Muscle Mass of the Bilateral Lower Limbs is Associated with Hyperuricemia in Females with Polycystic Ovarian Syndrome. Reprod Sci. 2023.

Li, X., Wu, W., Li, X., Wu, H., Wang, X., Tian, W., & Zhang, H. (2023). Excessively Increased Skeletal Muscle Mass of the Bilateral Lower Limbs is Associated with Hyperuricemia in Females with Polycystic Ovarian Syndrome. Reproductive Sciences (Thousand Oaks, Calif.). https://doi.org/10.1007/s43032-023-01214-y

Li X, et al. Excessively Increased Skeletal Muscle Mass of the Bilateral Lower Limbs Is Associated With Hyperuricemia in Females With Polycystic Ovarian Syndrome. Reprod Sci. 2023 Mar 21; PubMed PMID: 36944907.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Excessively Increased Skeletal Muscle Mass of the Bilateral Lower Limbs is Associated with Hyperuricemia in Females with Polycystic Ovarian Syndrome. AU - Li,Xiaoyan, AU - Wu,Wenxuan, AU - Li,Xue, AU - Wu,Hao, AU - Wang,Xiang, AU - Tian,Wenyan, AU - Zhang,Huiying, Y1 - 2023/03/21/ PY - 2022/07/06/received PY - 2023/03/10/accepted PY - 2023/3/22/entrez PY - 2023/3/23/pubmed PY - 2023/3/23/medline KW - Body composition measurements KW - Hyperuricemia KW - Polycystic ovary syndrome KW - Skeletal muscle mass JF - Reproductive sciences (Thousand Oaks, Calif.) JO - Reprod Sci N2 - This study is aimed at evaluating the correlation between the skeletal muscle mass index (SMI) of different body parts and hyperuricemia in females with polycystic ovary syndrome (PCOS), thus, providing scientific guidance on lifestyle self-management for patients with PCOS. The cross-sectional study included 171 patients with PCOS, which were divided into two distinct sub-groups based on the presence or absence of hyperuricemia. Anthropometric and serological characteristics of the population with PCOS focusing on skeletal muscle mass were conducted. PCOS patients with hyperuricemia had significantly greater SMI in different body parts. Further binary logistic regression analysis revealed that SMI of the bilateral lower limbs was positively associated with hyperuricemia with an adjusted odds ratio (95% confidence interval) of 1.235 (1.103 - 1.384), p < 0.001. The optimal cut-off value of SMI of the bilateral lower limbs in predicting hyperuricemia was 5.11 (Youden index = 0.490). Combined with the mean value of SMI in the bilateral upper limbs, the safe range of SMI of the bilateral lower limbs in patients with PCOS was calculated as 3.64 - 5.11, with the sensitivity and negative predictive values being 83.9% and 65.1%, respectively. Excessively increased SMI of the bilateral lower limbs was correlated with hyperuricemia in patients with PCOS. SN - 1933-7205 UR - https://www.unboundmedicine.com/medline/citation/36944907/Excessively_Increased_Skeletal_Muscle_Mass_of_the_Bilateral_Lower_Limbs_is_Associated_with_Hyperuricemia_in_Females_with_Polycystic_Ovarian_Syndrome_ DB - PRIME DP - Unbound Medicine ER -