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The effects of guar gum supplementation on glycemic control, body mass and blood pressure in adults: A GRADE-assessed systematic review and meta-analysis of randomized clinical trials.
Diabetes Res Clin Pract. 2023 May; 199:110604.DR

Abstract

BACKGROUND

This systematic review and meta-analysis sought to evaluate the effects ofguar gum supplementation on glycemic control, blood pressure, and body mass in adults.

METHODS

Relevant studies were obtained by searching the PubMed, SCOPUS, Embase, and Web of Science databases (from inception to January 2022). Weighted mean differences (WMD) and 95% confidence intervals (CIs) were pooled using a random-effects model. Heterogeneity, sensitivity analysis, and publication bias were reported using standard methods.

RESULTS

Pooled analysis of 14 randomized controlled trials (RCTs) revealed that guar gum supplementation led to significant reductions in hemoglobin A1c (HbA1c) (WMD: -0.47 mg/dL, 95% CI: -0.75, -0.18, p = 0.001). However, there was no effect on fasting blood sugar (FBS), systolic and diastolic blood pressure, and body mass among adults in comparison with the control group. A subgroup analysis demonstrated that intervention in patients with type 2 diabetes (T2DM), and high supplementation dosages (>15 g/d) significantly decreased FBS concentrations, but not in other subgroups.

CONCLUSION

Guar gum supplementation may yield a beneficial effect on glycemic control in T2DM patients. However, the extant clinical trials, thus far, are not sufficient enough to form guidelines for clinical practice.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Javad Alaeian M
Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: javadalaeian@gmail.com.
Pourreza S
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: sanaz.prrza@yahoo.com.
Yousefi M
Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: mykh1994@yahoo.com.
Golalipour E
Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: elnaazgolalipour@yahoo.com.
Setayesh L
Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE. Electronic address: setayesh.leila@yahoo.com.
Zeinali Khosroshahi M
Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: mz.med.edu@gmail.com.
Bagheri R
Department of Exercise Physiology, University of Isfahan, Isfahan, Iran. Electronic address: will.fivb@yahoo.com.
Ashtary-Larky D
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: Damoon_ashtary@yahoo.com.
Wong A
Department of Health and Human Performance, Marymount University, Arlington, United States. Electronic address: awong@marymount.edu.
Zamani M
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: md_zamany@yahoo.com.
Asbaghi O
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: omid.asbaghi@gmail.com.

MeSH

AdultHumansBlood GlucoseDietary SupplementsBlood PressureGlycemic ControlRandomized Controlled Trials as TopicDiabetes Mellitus, Type 2

Pub Type(s)

Meta-Analysis
Systematic Review
Journal Article
Review

Language

eng

PubMed ID

36958432

Citation

Javad Alaeian, Mohammad, et al. "The Effects of Guar Gum Supplementation On Glycemic Control, Body Mass and Blood Pressure in Adults: a GRADE-assessed Systematic Review and Meta-analysis of Randomized Clinical Trials." Diabetes Research and Clinical Practice, vol. 199, 2023, p. 110604.
Javad Alaeian M, Pourreza S, Yousefi M, et al. The effects of guar gum supplementation on glycemic control, body mass and blood pressure in adults: A GRADE-assessed systematic review and meta-analysis of randomized clinical trials. Diabetes Res Clin Pract. 2023;199:110604.
Javad Alaeian, M., Pourreza, S., Yousefi, M., Golalipour, E., Setayesh, L., Zeinali Khosroshahi, M., Bagheri, R., Ashtary-Larky, D., Wong, A., Zamani, M., & Asbaghi, O. (2023). The effects of guar gum supplementation on glycemic control, body mass and blood pressure in adults: A GRADE-assessed systematic review and meta-analysis of randomized clinical trials. Diabetes Research and Clinical Practice, 199, 110604. https://doi.org/10.1016/j.diabres.2023.110604
Javad Alaeian M, et al. The Effects of Guar Gum Supplementation On Glycemic Control, Body Mass and Blood Pressure in Adults: a GRADE-assessed Systematic Review and Meta-analysis of Randomized Clinical Trials. Diabetes Res Clin Pract. 2023;199:110604. PubMed PMID: 36958432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of guar gum supplementation on glycemic control, body mass and blood pressure in adults: A GRADE-assessed systematic review and meta-analysis of randomized clinical trials. AU - Javad Alaeian,Mohammad, AU - Pourreza,Sanaz, AU - Yousefi,Mohsen, AU - Golalipour,Elnaz, AU - Setayesh,Leila, AU - Zeinali Khosroshahi,Mohammad, AU - Bagheri,Reza, AU - Ashtary-Larky,Damoon, AU - Wong,Alexei, AU - Zamani,Mohammad, AU - Asbaghi,Omid, Y1 - 2023/03/22/ PY - 2022/4/13/received PY - 2022/11/13/revised PY - 2023/2/28/accepted PY - 2023/5/16/medline PY - 2023/3/24/pubmed PY - 2023/3/23/entrez KW - Blood pressure KW - Body weight KW - Glycemic control KW - Guar supplementation KW - Meta-analysis SP - 110604 EP - 110604 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 199 N2 - BACKGROUND: This systematic review and meta-analysis sought to evaluate the effects ofguar gum supplementation on glycemic control, blood pressure, and body mass in adults. METHODS: Relevant studies were obtained by searching the PubMed, SCOPUS, Embase, and Web of Science databases (from inception to January 2022). Weighted mean differences (WMD) and 95% confidence intervals (CIs) were pooled using a random-effects model. Heterogeneity, sensitivity analysis, and publication bias were reported using standard methods. RESULTS: Pooled analysis of 14 randomized controlled trials (RCTs) revealed that guar gum supplementation led to significant reductions in hemoglobin A1c (HbA1c) (WMD: -0.47 mg/dL, 95% CI: -0.75, -0.18, p = 0.001). However, there was no effect on fasting blood sugar (FBS), systolic and diastolic blood pressure, and body mass among adults in comparison with the control group. A subgroup analysis demonstrated that intervention in patients with type 2 diabetes (T2DM), and high supplementation dosages (>15 g/d) significantly decreased FBS concentrations, but not in other subgroups. CONCLUSION: Guar gum supplementation may yield a beneficial effect on glycemic control in T2DM patients. However, the extant clinical trials, thus far, are not sufficient enough to form guidelines for clinical practice. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/36958432/The_effects_of_guar_gum_supplementation_on_glycemic_control_body_mass_and_blood_pressure_in_adults:_a_GRADE_assessed_systematic_review_and_meta_analysis_of_randomized_clinical_trials_ DB - PRIME DP - Unbound Medicine ER -

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