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Effect of probiotic yogurt consumption on glycemic control and lipid profile in patients with type 2 diabetes mellitus: A randomized controlled trial.
Clin Nutr ESPEN. 2023 Apr; 54:144-149.CN

Abstract

BACKGROUND & AIMS

Type 2 diabetes mellitus (T2DM) is a common endocrine disease. Altered gut microbiota (Dysbiosis) is closely associated with development of T2DM. Growing body of evidence hypothesized that probiotics intake may be useful for patients with T2DM. We investigated the effect of probiotic yogurt consumption on glycemic control and lipid profile in patients with T2DM.

METHODS

In this 12-week randomized controlled clinical trial, seventy-two patients with T2DM were randomly assigned to the intervention group (IG) that received 200 g/d probiotic yogurt containing 4.65 × 106 CFU/g Lactobacillus acidophilus and Bifidobacterium lactis) or placebo group (PG) that received 200 g/d conventional yogurt.

RESULTS

We found no difference between two groups in fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-c) and low density lipoprotein-cholesterol (LDL-c) after intervention. After adjusting for baseline values of covariate, a significant reduction in HbA1c (mean change: -0.76 ± 1.3 vs. -0.15 ± 1.3; P = 0.01), TC (mean change: -10.61 ± 27.8 vs. -2.97 ± 35.0; P = 0.02) and LDL-c (mean change: -8.62 ± 21.7 vs. 0.02 ± 25.8; P = 0.004) was observed in the IG compared to the PG. In addition, a non-significant trend to reduction was observed in term of FPG (mean change: -19.61 ± 29.1 vs. -4.19 ± 24.2; P = 0.13). TG and HDL-c remained unchanged.

CONCLUSIONS

Probiotic yogurt consumption may be useful for patients with T2DM. More well-designed clinical trials with longer intervention duration are required. Registered on 30 July 2022 at Iranian Registry of Clinical Trials (IRCT20220226054125N1) with URL: https://www.irct.ir/trial/62304.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Mirjalili M
Clinical Research Development Center of Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Salari Sharif A
Research Center of Nursing and Midwifery Care, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Sangouni AA
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Emtiazi H
Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mozaffari-Khosravi H
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Nutrition and Food Security Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Yazd Diabetic Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address: mozaffari.kh@gmail.com.

MeSH

HumansDiabetes Mellitus, Type 2YogurtGlycated HemoglobinCholesterol, LDLGlycemic ControlIranTriglyceridesProbioticsCholesterol, HDL

Pub Type(s)

Randomized Controlled Trial
Journal Article

Language

eng

PubMed ID

36963856

Citation

Mirjalili, Mohammadreza, et al. "Effect of Probiotic Yogurt Consumption On Glycemic Control and Lipid Profile in Patients With Type 2 Diabetes Mellitus: a Randomized Controlled Trial." Clinical Nutrition ESPEN, vol. 54, 2023, pp. 144-149.
Mirjalili M, Salari Sharif A, Sangouni AA, et al. Effect of probiotic yogurt consumption on glycemic control and lipid profile in patients with type 2 diabetes mellitus: A randomized controlled trial. Clin Nutr ESPEN. 2023;54:144-149.
Mirjalili, M., Salari Sharif, A., Sangouni, A. A., Emtiazi, H., & Mozaffari-Khosravi, H. (2023). Effect of probiotic yogurt consumption on glycemic control and lipid profile in patients with type 2 diabetes mellitus: A randomized controlled trial. Clinical Nutrition ESPEN, 54, 144-149. https://doi.org/10.1016/j.clnesp.2023.01.014
Mirjalili M, et al. Effect of Probiotic Yogurt Consumption On Glycemic Control and Lipid Profile in Patients With Type 2 Diabetes Mellitus: a Randomized Controlled Trial. Clin Nutr ESPEN. 2023;54:144-149. PubMed PMID: 36963856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of probiotic yogurt consumption on glycemic control and lipid profile in patients with type 2 diabetes mellitus: A randomized controlled trial. AU - Mirjalili,Mohammadreza, AU - Salari Sharif,Ali, AU - Sangouni,Abbas Ali, AU - Emtiazi,Hamideh, AU - Mozaffari-Khosravi,Hassan, Y1 - 2023/01/20/ PY - 2022/9/13/received PY - 2022/12/20/revised PY - 2023/1/11/accepted PY - 2023/3/28/medline PY - 2023/3/24/entrez PY - 2023/3/25/pubmed KW - Glycemic control KW - Lipid profile KW - Probiotics KW - Type 2 diabetes mellitus SP - 144 EP - 149 JF - Clinical nutrition ESPEN JO - Clin Nutr ESPEN VL - 54 N2 - BACKGROUND & AIMS: Type 2 diabetes mellitus (T2DM) is a common endocrine disease. Altered gut microbiota (Dysbiosis) is closely associated with development of T2DM. Growing body of evidence hypothesized that probiotics intake may be useful for patients with T2DM. We investigated the effect of probiotic yogurt consumption on glycemic control and lipid profile in patients with T2DM. METHODS: In this 12-week randomized controlled clinical trial, seventy-two patients with T2DM were randomly assigned to the intervention group (IG) that received 200 g/d probiotic yogurt containing 4.65 × 106 CFU/g Lactobacillus acidophilus and Bifidobacterium lactis) or placebo group (PG) that received 200 g/d conventional yogurt. RESULTS: We found no difference between two groups in fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-c) and low density lipoprotein-cholesterol (LDL-c) after intervention. After adjusting for baseline values of covariate, a significant reduction in HbA1c (mean change: -0.76 ± 1.3 vs. -0.15 ± 1.3; P = 0.01), TC (mean change: -10.61 ± 27.8 vs. -2.97 ± 35.0; P = 0.02) and LDL-c (mean change: -8.62 ± 21.7 vs. 0.02 ± 25.8; P = 0.004) was observed in the IG compared to the PG. In addition, a non-significant trend to reduction was observed in term of FPG (mean change: -19.61 ± 29.1 vs. -4.19 ± 24.2; P = 0.13). TG and HDL-c remained unchanged. CONCLUSIONS: Probiotic yogurt consumption may be useful for patients with T2DM. More well-designed clinical trials with longer intervention duration are required. Registered on 30 July 2022 at Iranian Registry of Clinical Trials (IRCT20220226054125N1) with URL: https://www.irct.ir/trial/62304. SN - 2405-4577 UR - https://www.unboundmedicine.com/medline/citation/36963856/Effect_of_probiotic_yogurt_consumption_on_glycemic_control_and_lipid_profile_in_patients_with_type_2_diabetes_mellitus:_A_randomized_controlled_trial_ DB - PRIME DP - Unbound Medicine ER -

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