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Increased blood viscosity in diabetic proliferative retinopathy.
Diabetes Res 1986; 3(2):67-70DR

Abstract

Blood rheology and haemostasis were assessed in 18 diabetics with proliferative retinopathy and in 18 diabetics without proliferative retinopathy, matched for age, sex, smoking habit and type, duration and treatment of diabetes. Proliferative retinopathy was associated with significantly higher levels of blood viscosity at high and low shear rates, which were related to higher levels of plasma viscosity and fibrinogen. Blood urea, glucose, glycosylated haemoglobin and white cell count were also significantly higher, whereas haematocrit, red cell deformability and several other haematological and biochemical variables did not differ significantly in the 2 groups. In view of these findings, and of our recent demonstration that increased blood viscosity also exists in those patients with retinal vein occlusion who develop a similar proliferative retinopathy, we suggest that hyperviscosity may contribute to retinal ischaemia and hence proliferative retinopathy.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3698481

Citation

Lowe, G D., et al. "Increased Blood Viscosity in Diabetic Proliferative Retinopathy." Diabetes Research (Edinburgh, Scotland), vol. 3, no. 2, 1986, pp. 67-70.
Lowe GD, Ghafour IM, Belch JJ, et al. Increased blood viscosity in diabetic proliferative retinopathy. Diabetes Res. 1986;3(2):67-70.
Lowe, G. D., Ghafour, I. M., Belch, J. J., Forbes, C. D., Foulds, W. S., & MacCuish, A. C. (1986). Increased blood viscosity in diabetic proliferative retinopathy. Diabetes Research (Edinburgh, Scotland), 3(2), pp. 67-70.
Lowe GD, et al. Increased Blood Viscosity in Diabetic Proliferative Retinopathy. Diabetes Res. 1986;3(2):67-70. PubMed PMID: 3698481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased blood viscosity in diabetic proliferative retinopathy. AU - Lowe,G D, AU - Ghafour,I M, AU - Belch,J J, AU - Forbes,C D, AU - Foulds,W S, AU - MacCuish,A C, PY - 1986/2/1/pubmed PY - 1986/2/1/medline PY - 1986/2/1/entrez SP - 67 EP - 70 JF - Diabetes research (Edinburgh, Scotland) JO - Diabetes Res. VL - 3 IS - 2 N2 - Blood rheology and haemostasis were assessed in 18 diabetics with proliferative retinopathy and in 18 diabetics without proliferative retinopathy, matched for age, sex, smoking habit and type, duration and treatment of diabetes. Proliferative retinopathy was associated with significantly higher levels of blood viscosity at high and low shear rates, which were related to higher levels of plasma viscosity and fibrinogen. Blood urea, glucose, glycosylated haemoglobin and white cell count were also significantly higher, whereas haematocrit, red cell deformability and several other haematological and biochemical variables did not differ significantly in the 2 groups. In view of these findings, and of our recent demonstration that increased blood viscosity also exists in those patients with retinal vein occlusion who develop a similar proliferative retinopathy, we suggest that hyperviscosity may contribute to retinal ischaemia and hence proliferative retinopathy. SN - 0265-5985 UR - https://www.unboundmedicine.com/medline/citation/3698481/Increased_blood_viscosity_in_diabetic_proliferative_retinopathy_ L2 - https://medlineplus.gov/diabeticeyeproblems.html DB - PRIME DP - Unbound Medicine ER -