TY - JOUR T1 - The Complex Effects of Light on Metabolism in Humans. AU - Ishihara,Asuka, AU - Courville,Amber B, AU - Chen,Kong Y, Y1 - 2023/03/14/ PY - 2023/2/4/received PY - 2023/3/8/revised PY - 2023/3/10/accepted PY - 2023/3/30/medline PY - 2023/3/29/entrez PY - 2023/3/30/pubmed KW - circadian rhythm KW - light KW - melatonin KW - metabolism KW - sleep JF - Nutrients JO - Nutrients VL - 15 IS - 6 N2 - Light is an essential part of many life forms. The natural light-dark cycle has been the dominant stimulus for circadian rhythms throughout human evolution. Artificial light has restructured human activity and provided opportunities to extend the day without reliance on natural day-night cycles. The increase in light exposure at unwanted times or a reduced dynamic range of light between the daytime and nighttime has introduced negative consequences for human health. Light exposure is closely linked to sleep-wake regulation, activity and eating patterns, body temperature, and energy metabolism. Disruptions to these areas due to light are linked to metabolic abnormalities such as an increased risk of obesity and diabetes. Research has revealed that various properties of light influence metabolism. This review will highlight the complex role of light in human physiology, with a specific emphasis on metabolic regulation from the perspective of four main properties of light (intensity, duration, timing of exposure, and wavelength). We also discuss the potential influence of the key circadian hormone melatonin on sleep and metabolic physiology. We explore the relationship between light and metabolism through circadian physiology in various populations to understand the optimal use of light to mitigate short and long-term health consequences. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/36986120/The_Complex_Effects_of_Light_on_Metabolism_in_Humans_ DB - PRIME DP - Unbound Medicine ER -