TY - JOUR T1 - The anaphylatoxin C5a: Structure, function, signaling, physiology, disease, and therapeutics. AU - Ghosh,Manaswini, AU - Rana,Soumendra, Y1 - 2023/03/28/ PY - 2023/1/15/received PY - 2023/3/6/revised PY - 2023/3/21/accepted PY - 2023/4/25/medline PY - 2023/3/30/pubmed PY - 2023/3/29/entrez KW - C5a KW - C5aR1, C5aR2 KW - Disease KW - Therapeutics SP - 110081 EP - 110081 JF - International immunopharmacology JO - Int Immunopharmacol VL - 118 N2 - The complement system is one of the oldest known tightly regulated host defense systems evolved for efficiently functioning cell-based immune systems and antibodies. Essentially, the complement system acts as a pivot between the innate and adaptive arms of the immune system. The complement system collectively represents a cocktail of ∼50 cell-bound/soluble glycoproteins directly involved in controlling infection and inflammation. Activation of the complement cascade generates complement fragments like C3a, C4a, and C5a as anaphylatoxins. C5a is the most potent proinflammatory anaphylatoxin, which is involved in inflammatory signaling in a myriad of tissues. This review provides a comprehensive overview of human C5a in the context of its structure and signaling under several pathophysiological conditions, including the current and future therapeutic applications targeting C5a. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/36989901/The_anaphylatoxin_C5a:_Structure_function_signaling_physiology_disease_and_therapeutics_ DB - PRIME DP - Unbound Medicine ER -