TY - JOUR T1 - SARS-CoV-2 Spike-Mediated Entry and Its Regulation by Host Innate Immunity. AU - Yu,Shi, AU - Hu,Huina, AU - Ai,Qiangyun, AU - Bai,Rong, AU - Ma,Kaixiong, AU - Zhou,Minmin, AU - Wang,Shaobo, Y1 - 2023/02/27/ PY - 2022/12/26/received PY - 2023/02/15/revised PY - 2023/02/15/accepted PY - 2023/3/31/medline PY - 2023/3/30/entrez PY - 2023/3/31/pubmed KW - S1 KW - S2 KW - SARS-CoV-2 KW - host proteases KW - innate immune responses KW - proteolytic processing KW - spike KW - virus host interaction JF - Viruses JO - Viruses VL - 15 IS - 3 N2 - The constantly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) fuel the worldwide coronavirus disease (COVID-19) pandemic. The spike protein is essential for the SARS-CoV-2 viral entry and thus has been extensively targeted by therapeutic antibodies. However, mutations along the spike in SARS-CoV-2 VOC and Omicron subvariants have caused more rapid spread and strong antigenic drifts, rendering most of the current antibodies ineffective. Hence, understanding and targeting the molecular mechanism of spike activation is of great interest in curbing the spread and development of new therapeutic approaches. In this review, we summarize the conserved features of spike-mediated viral entry in various SARS-CoV-2 VOC and highlight the converging proteolytic processes involved in priming and activating the spike. We also summarize the roles of innate immune factors in preventing spike-driven membrane fusion and provide outlines for the identification of novel therapeutics against coronavirus infections. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/36992348/SARS_CoV_2_Spike_Mediated_Entry_and_Its_Regulation_by_Host_Innate_Immunity_ DB - PRIME DP - Unbound Medicine ER -