Cold Sensitivity in Ulnar Neuropathy at the Elbow - Relation to Symptoms and Disability, Influence of Diabetes and Impact on Surgical Outcome.
Front Clin Diabetes Healthc. 2021; 2:719104.FC

Abstract

Cold sensitivity, an abnormal response to exposure to cold, is debilitating. It often affects people with nerve injuries and diabetes. Knowledge about the occurrence and prognostic impact of cold sensitivity in people with ulnar neuropathy at the elbow (UNE) is limited. We aimed to investigate the occurrence of cold sensitivity in UNE in relation to disability, the influence of diabetes and impact on surgical outcome. Data concerning 1270 persons operated on for UNE from 2010-2016 from the Swedish National Register for Hand Surgery (HAKIR) were matched with data from the Swedish National Diabetes Register (NDR). Disability and symptoms were assessed preoperatively, and at three and 12 months postoperatively using QuickDASH and a symptom-specific survey (HQ-8) containing one item regarding cold sensitivity. Differences regarding grade of cold sensitivity, occurrence of diabetes, QuickDASH scores and HQ-8 scores were studied. A linear regression analysis was performed to predict surgical outcome based on preoperative cold sensitivity. The mean age of the cases was 52 ± SD 14 years and 48% were women. Preoperatively, 427 answered the questionnaire. Severe cold sensitivity was present in 140/427 (33%) cases, moderate in 164/427 (38%) and mild in 123/427 (29%) cases. Cases with severe preoperative cold sensitivity reported higher QuickDASH scores at all times compared to cases with mild cold sensitivity. Relative change in QuickDASH scores over time did not differ between the groups. Cases with diabetes reported worse cold sensitivity preoperatively, but not postoperatively. All HQ-8 items improved with surgery, but cases with severe cold sensitivity reported worse persisting symptoms. Cold sensitivity is a major problem among those with UNE and an even greater preoperative problem among people with diabetes. It is associated with more symptoms and disability pre- and post-operatively. All cases, regardless of preoperative degree of cold sensitivity improve with surgery.

Links

PMC Free PDF

Authors+Show Affiliations

Zimmerman M

Department of Orthopaedics, Helsingborg Hospital, Helsingborg, Sweden. Department of Translational Medicine - Hand Surgery, Lund University, Malmö, Sweden.

Peyron H

Department of Orthopaedics, Helsingborg Hospital, Helsingborg, Sweden. Department of Translational Medicine - Hand Surgery, Lund University, Malmö, Sweden.

Svensson AM

National Diabetes Register, Centre of Registers, Gothenburg, Sweden. Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.

Eeg-Olofsson K

Department of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.

Nyman E

Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden. Department of Hand Surgery, Plastic Surgery and Burns, Linköping University Hospital, Linköping, Sweden.

Dahlin LB

Department of Translational Medicine - Hand Surgery, Lund University, Malmö, Sweden. Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden. Department of Hand Surgery, Skåne University Hospital, Malmö, Sweden.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

36994349

Citation

Zimmerman, Malin, et al. "Cold Sensitivity in Ulnar Neuropathy at the Elbow - Relation to Symptoms and Disability, Influence of Diabetes and Impact On Surgical Outcome." Frontiers in Clinical Diabetes and Healthcare, vol. 2, 2021, p. 719104.

Zimmerman M, Peyron H, Svensson AM, et al. Cold Sensitivity in Ulnar Neuropathy at the Elbow - Relation to Symptoms and Disability, Influence of Diabetes and Impact on Surgical Outcome. Front Clin Diabetes Healthc. 2021;2:719104.

Zimmerman, M., Peyron, H., Svensson, A. M., Eeg-Olofsson, K., Nyman, E., & Dahlin, L. B. (2021). Cold Sensitivity in Ulnar Neuropathy at the Elbow - Relation to Symptoms and Disability, Influence of Diabetes and Impact on Surgical Outcome. Frontiers in Clinical Diabetes and Healthcare, 2, 719104. https://doi.org/10.3389/fcdhc.2021.719104

Zimmerman M, et al. Cold Sensitivity in Ulnar Neuropathy at the Elbow - Relation to Symptoms and Disability, Influence of Diabetes and Impact On Surgical Outcome. Front Clin Diabetes Healthc. 2021;2:719104. PubMed PMID: 36994349.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Cold Sensitivity in Ulnar Neuropathy at the Elbow - Relation to Symptoms and Disability, Influence of Diabetes and Impact on Surgical Outcome. AU - Zimmerman,Malin, AU - Peyron,Hanna, AU - Svensson,Ann-Marie, AU - Eeg-Olofsson,Katarina, AU - Nyman,Erika, AU - Dahlin,Lars B, Y1 - 2021/08/16/ PY - 2021/6/1/received PY - 2021/7/27/accepted PY - 2021/8/16/medline PY - 2023/3/30/entrez PY - 2021/8/16/pubmed KW - diabetes KW - diabetic neuropathy KW - patient report outcome measure (PRO) KW - ulnar nerve KW - ulnar nerve compression neuropathy SP - 719104 EP - 719104 JF - Frontiers in clinical diabetes and healthcare JO - Front Clin Diabetes Healthc VL - 2 N2 - Cold sensitivity, an abnormal response to exposure to cold, is debilitating. It often affects people with nerve injuries and diabetes. Knowledge about the occurrence and prognostic impact of cold sensitivity in people with ulnar neuropathy at the elbow (UNE) is limited. We aimed to investigate the occurrence of cold sensitivity in UNE in relation to disability, the influence of diabetes and impact on surgical outcome. Data concerning 1270 persons operated on for UNE from 2010-2016 from the Swedish National Register for Hand Surgery (HAKIR) were matched with data from the Swedish National Diabetes Register (NDR). Disability and symptoms were assessed preoperatively, and at three and 12 months postoperatively using QuickDASH and a symptom-specific survey (HQ-8) containing one item regarding cold sensitivity. Differences regarding grade of cold sensitivity, occurrence of diabetes, QuickDASH scores and HQ-8 scores were studied. A linear regression analysis was performed to predict surgical outcome based on preoperative cold sensitivity. The mean age of the cases was 52 ± SD 14 years and 48% were women. Preoperatively, 427 answered the questionnaire. Severe cold sensitivity was present in 140/427 (33%) cases, moderate in 164/427 (38%) and mild in 123/427 (29%) cases. Cases with severe preoperative cold sensitivity reported higher QuickDASH scores at all times compared to cases with mild cold sensitivity. Relative change in QuickDASH scores over time did not differ between the groups. Cases with diabetes reported worse cold sensitivity preoperatively, but not postoperatively. All HQ-8 items improved with surgery, but cases with severe cold sensitivity reported worse persisting symptoms. Cold sensitivity is a major problem among those with UNE and an even greater preoperative problem among people with diabetes. It is associated with more symptoms and disability pre- and post-operatively. All cases, regardless of preoperative degree of cold sensitivity improve with surgery. SN - 2673-6616 UR - https://www.unboundmedicine.com/medline/citation/36994349/Cold_Sensitivity_in_Ulnar_Neuropathy_at_the_Elbow___Relation_to_Symptoms_and_Disability_Influence_of_Diabetes_and_Impact_on_Surgical_Outcome_ DB - PRIME DP - Unbound Medicine ER -

Tags

Cold Sensitivity in Ulnar Neuropathy at the Elbow - Relation to Symptoms and Disability, Influence of Diabetes and Impact on Surgical Outcome.Front Clin Diabetes Healthc. 2021; 2:719104.FC