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[Determination of 11 Cannabinoids in Cannabis sativa L. by Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (LC-Q-TOF-MS)].
Yakugaku Zasshi. 2023; 143(4):411-418.YZ

Abstract

Eleven major cannabinoids from each subdivided tissue of drug-type and fiber-type cannabis plants were determined by means of a liquid chromatography quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS). The cannabinoids analyzed in this study were tetrahydrocannabinol acid (THCA), Δ9-tetrahydrocannabinol (Δ9-THC), cannabidiol acid (CBDA), cannabidiol (CBD), Δ8-tetrahydrocannabinol (Δ8-THC), cannabinol (CBN), cannabichromene (CBC), cannabidivarin (CBDV), cannabigerolic acid (CBGA), cannabigerol (CBG) and tetrahydrocannabivarin (THCV). As a result, THCA was detected in the bracts at 28.4 µg/mg, in the buds at 24.8 µg/mg, and in the leaves at 5.1 to 10.5 µg/mg in the drug-type cannabis plant. In addition, Δ9-THC, CBGA, CBN, CBG, CBC, and THCV were mainly detected in bracts, buds, and leaves. On the other hand, as for the fiber-type cannabis plant, CBDA was detected in the bracts at 27.5 µg/mg, in the buds at 10.6 µg/mg, and in the leaves at 1.5-3.3 µg/mg. In addition, Δ9-THCA, CBD, Δ9-THC, CBC, and CBG were mainly detected in bracts, buds, and leaves.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Tanaka R
Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences.
Mizutani S
Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences.
Kawamura M
Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences.
Fuchino H
Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and Nutrition.
Kawahara N
Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and Nutrition. The Kochi Prefectural Makino Botanical Garden.
Kikura-Hanajiri R
Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences.

MeSH

CannabisDronabinolCannabidiolCannabinoidsChromatography, LiquidMass SpectrometryCannabinol

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

37005243

Citation

Tanaka, Rie, et al. "[Determination of 11 Cannabinoids in Cannabis Sativa L. By Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (LC-Q-TOF-MS)]." Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan, vol. 143, no. 4, 2023, pp. 411-418.
Tanaka R, Mizutani S, Kawamura M, et al. [Determination of 11 Cannabinoids in Cannabis sativa L. by Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (LC-Q-TOF-MS)]. Yakugaku Zasshi. 2023;143(4):411-418.
Tanaka, R., Mizutani, S., Kawamura, M., Fuchino, H., Kawahara, N., & Kikura-Hanajiri, R. (2023). [Determination of 11 Cannabinoids in Cannabis sativa L. by Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (LC-Q-TOF-MS)]. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan, 143(4), 411-418. https://doi.org/10.1248/yakushi.22-00198
Tanaka R, et al. [Determination of 11 Cannabinoids in Cannabis Sativa L. By Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (LC-Q-TOF-MS)]. Yakugaku Zasshi. 2023;143(4):411-418. PubMed PMID: 37005243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Determination of 11 Cannabinoids in Cannabis sativa L. by Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (LC-Q-TOF-MS)]. AU - Tanaka,Rie, AU - Mizutani,Sakumi, AU - Kawamura,Maiko, AU - Fuchino,Hiroyuki, AU - Kawahara,Nobuo, AU - Kikura-Hanajiri,Ruri, PY - 2023/4/4/medline PY - 2023/4/2/entrez PY - 2023/4/3/pubmed KW - Cannabis sativa L KW - cannabinois KW - liquid chromatography KW - mass spectrometry SP - 411 EP - 418 JF - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan JO - Yakugaku Zasshi VL - 143 IS - 4 N2 - Eleven major cannabinoids from each subdivided tissue of drug-type and fiber-type cannabis plants were determined by means of a liquid chromatography quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS). The cannabinoids analyzed in this study were tetrahydrocannabinol acid (THCA), Δ9-tetrahydrocannabinol (Δ9-THC), cannabidiol acid (CBDA), cannabidiol (CBD), Δ8-tetrahydrocannabinol (Δ8-THC), cannabinol (CBN), cannabichromene (CBC), cannabidivarin (CBDV), cannabigerolic acid (CBGA), cannabigerol (CBG) and tetrahydrocannabivarin (THCV). As a result, THCA was detected in the bracts at 28.4 µg/mg, in the buds at 24.8 µg/mg, and in the leaves at 5.1 to 10.5 µg/mg in the drug-type cannabis plant. In addition, Δ9-THC, CBGA, CBN, CBG, CBC, and THCV were mainly detected in bracts, buds, and leaves. On the other hand, as for the fiber-type cannabis plant, CBDA was detected in the bracts at 27.5 µg/mg, in the buds at 10.6 µg/mg, and in the leaves at 1.5-3.3 µg/mg. In addition, Δ9-THCA, CBD, Δ9-THC, CBC, and CBG were mainly detected in bracts, buds, and leaves. SN - 1347-5231 UR - https://www.unboundmedicine.com/medline/citation/37005243/[Determination_of_11_Cannabinoids_in_Cannabis_sativa_L__by_Liquid_Chromatography_Quadrupole_Time_of_Flight_Mass_Spectrometry__LC_Q_TOF_MS_]_ DB - PRIME DP - Unbound Medicine ER -