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Serum 25-hydroxyvitamin D concentrations are inversely associated with all-cause mortality among Koreans: a nationwide cohort study.
Nutr Res. 2023 May; 113:49-58.NR

Abstract

Evidence on the association between serum 25-hydroxyvitamin D (25(OH)D) concentration and all-cause and cause-specific mortality in Asians, especially Koreans, is limited. We hypothesized that high concentrations of 25(OH)D are associated with lower all-cause and cause-specific mortality in the general Korean population. This study included 27,846 adults participating in the Fourth and Fifth Korean National Health and Nutrition Examination Survey 2008-2012, followed up through December 31, 2019. Hazard ratios (HR) and 95% confidence intervals (CIs) for mortality from all causes, cardiovascular disease (CVD), and cancer were estimated using multivariable-adjusted Cox proportional hazards regression. The weighted mean serum 25(OH)D of study participants was 17.77 ng/mL; 66.5% had vitamin D deficiency (<20 ng/mL) and 94.2% had insufficient vitamin D (<30 ng/mL). During a median follow-up of 9.4 years (interquartile range, 8.1-10.6 years), 1680 deaths were documented, including 362 CVD deaths and 570 cancer deaths. Serum 25(OH)D levels ≥30 ng/mL were inversely associated with all-cause mortality (HR, 0.57; 95% CI, 0.43-0.75) compared with serum 25(OH)D levels <10 ng/mL. Based on the quartile cutoffs of serum 25(OH)D concentration, the highest quartile of serum 25(OH)D concentration (≥21.8 ng/mL) was associated with the lowest all-cause mortality (HR, 0.72; 95% CI, 0.60-0.85; P trend < .001), and CVD mortality (HR, 0.60; 95% CI, 0.42-0.85; P trend = .006). No association with cancer mortality outcome was found. In conclusion, higher serum 25(OH)D levels were associated with lower all-cause mortality in the general Korean population. An additional association was found between higher quartile of serum 25(OH)D and lower CVD mortality.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Park KY
Department of Family Medicine, Hanyang University College of Medicine, South Korea.
Han K
Department of Statistics and Actuarial Science, Soongsil University, Seoul, South Korea.
Hwang HS
Department of Family Medicine, Hanyang University College of Medicine, South Korea. Electronic address: fmhwang@hanyang.ac.kr.
Park HK
Department of Family Medicine, Hanyang University College of Medicine, South Korea.
Park K
Department of Family Medicine, Hanyang University College of Medicine, South Korea.

MeSH

AdultHumansCohort StudiesCause of DeathNutrition SurveysEast Asian PeopleVitamin DCardiovascular DiseasesVitamin D DeficiencyCalcifediolNeoplasmsRisk Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

37028268

Citation

Park, Kye-Yeung, et al. "Serum 25-hydroxyvitamin D Concentrations Are Inversely Associated With All-cause Mortality Among Koreans: a Nationwide Cohort Study." Nutrition Research (New York, N.Y.), vol. 113, 2023, pp. 49-58.
Park KY, Han K, Hwang HS, et al. Serum 25-hydroxyvitamin D concentrations are inversely associated with all-cause mortality among Koreans: a nationwide cohort study. Nutr Res. 2023;113:49-58.
Park, K. Y., Han, K., Hwang, H. S., Park, H. K., & Park, K. (2023). Serum 25-hydroxyvitamin D concentrations are inversely associated with all-cause mortality among Koreans: a nationwide cohort study. Nutrition Research (New York, N.Y.), 113, 49-58. https://doi.org/10.1016/j.nutres.2023.02.008
Park KY, et al. Serum 25-hydroxyvitamin D Concentrations Are Inversely Associated With All-cause Mortality Among Koreans: a Nationwide Cohort Study. Nutr Res. 2023;113:49-58. PubMed PMID: 37028268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25-hydroxyvitamin D concentrations are inversely associated with all-cause mortality among Koreans: a nationwide cohort study. AU - Park,Kye-Yeung, AU - Han,Kyungdo, AU - Hwang,Hwan-Sik, AU - Park,Hoon-Ki, AU - Park,Kyongmin, Y1 - 2023/03/05/ PY - 2022/9/13/received PY - 2023/2/21/revised PY - 2023/2/25/accepted PY - 2023/4/8/pubmed PY - 2023/4/8/medline PY - 2023/4/7/entrez KW - 25(OH)D KW - Epidemiology KW - KNHANES KW - Mortality KW - Vitamin D SP - 49 EP - 58 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 113 N2 - Evidence on the association between serum 25-hydroxyvitamin D (25(OH)D) concentration and all-cause and cause-specific mortality in Asians, especially Koreans, is limited. We hypothesized that high concentrations of 25(OH)D are associated with lower all-cause and cause-specific mortality in the general Korean population. This study included 27,846 adults participating in the Fourth and Fifth Korean National Health and Nutrition Examination Survey 2008-2012, followed up through December 31, 2019. Hazard ratios (HR) and 95% confidence intervals (CIs) for mortality from all causes, cardiovascular disease (CVD), and cancer were estimated using multivariable-adjusted Cox proportional hazards regression. The weighted mean serum 25(OH)D of study participants was 17.77 ng/mL; 66.5% had vitamin D deficiency (<20 ng/mL) and 94.2% had insufficient vitamin D (<30 ng/mL). During a median follow-up of 9.4 years (interquartile range, 8.1-10.6 years), 1680 deaths were documented, including 362 CVD deaths and 570 cancer deaths. Serum 25(OH)D levels ≥30 ng/mL were inversely associated with all-cause mortality (HR, 0.57; 95% CI, 0.43-0.75) compared with serum 25(OH)D levels <10 ng/mL. Based on the quartile cutoffs of serum 25(OH)D concentration, the highest quartile of serum 25(OH)D concentration (≥21.8 ng/mL) was associated with the lowest all-cause mortality (HR, 0.72; 95% CI, 0.60-0.85; P trend < .001), and CVD mortality (HR, 0.60; 95% CI, 0.42-0.85; P trend = .006). No association with cancer mortality outcome was found. In conclusion, higher serum 25(OH)D levels were associated with lower all-cause mortality in the general Korean population. An additional association was found between higher quartile of serum 25(OH)D and lower CVD mortality. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/37028268/Serum_25_hydroxyvitamin_D_concentrations_are_inversely_associated_with_all_cause_mortality_among_Koreans:_a_nationwide_cohort_study_ DB - PRIME DP - Unbound Medicine ER -