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A necroptic study of the prevalence of cholelithiasis in liver cirrhosis.
Med Interne. 1986 Jan-Mar; 24(1):23-7.MI

Abstract

The prevalence of cholelithiasis in liver cirrhosis was analyzed on 1320 consecutive necropsies which included 245 subjects with gallstones and 133 with liver cirrhosis. Gallstones were found in 24.8% of the cirrhotics, a prevalence significantly higher than in noncirrhotic subjects (17.8%) (p less than 0.05), and were more frequent in cirrhosis for all age-groups. The mean age of death was lower in cirrhotic than in noncirrhotic subjects (p less than 0.05). It was also lower, but without statistical significance, in cirrhotics without gallstones than in cirrhotics having gallstones. The ratio between lithiasic women and men was 0.8/1 in liver cirrhosis, as compared to 1.6/1 in noncirrhotic subjects. The proportion of pigment stones was significantly increased in liver cirrhosis (47.5%) (p less than 0.02). Chronic hemolysis secondary to hypersplenism, a know lithogenic factor in liver cirrhosis, might account for the predominance of pigment stones in this disease. Other lithogenic factors could be hyperestrogenism, changes in the proportion of biliary lipids etc. Complications of gallstones occurred less frequently in cirrhotic than in noncirrhotic patients, but complications of cholecystectomy represented the cause of death in 27.2% of cirrhotics as compared to 14.0% of noncirrhotic patients (p less than 0.02). These observations argue for a conservative, non-surgical attitude towards silent or uncomplicated gallstones in cirrhotic patient.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3704500

Citation

Acalovschi, M, et al. "A Necroptic Study of the Prevalence of Cholelithiasis in Liver Cirrhosis." Medecine Interne, vol. 24, no. 1, 1986, pp. 23-7.
Acalovschi M, Dumitraşcu D, Ban A, et al. A necroptic study of the prevalence of cholelithiasis in liver cirrhosis. Med Interne. 1986;24(1):23-7.
Acalovschi, M., Dumitraşcu, D., Ban, A., & Petrescu, A. (1986). A necroptic study of the prevalence of cholelithiasis in liver cirrhosis. Medecine Interne, 24(1), 23-7.
Acalovschi M, et al. A Necroptic Study of the Prevalence of Cholelithiasis in Liver Cirrhosis. Med Interne. 1986 Jan-Mar;24(1):23-7. PubMed PMID: 3704500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A necroptic study of the prevalence of cholelithiasis in liver cirrhosis. AU - Acalovschi,M, AU - Dumitraşcu,D, AU - Ban,A, AU - Petrescu,A, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 23 EP - 7 JF - Medecine interne JO - Med Interne VL - 24 IS - 1 N2 - The prevalence of cholelithiasis in liver cirrhosis was analyzed on 1320 consecutive necropsies which included 245 subjects with gallstones and 133 with liver cirrhosis. Gallstones were found in 24.8% of the cirrhotics, a prevalence significantly higher than in noncirrhotic subjects (17.8%) (p less than 0.05), and were more frequent in cirrhosis for all age-groups. The mean age of death was lower in cirrhotic than in noncirrhotic subjects (p less than 0.05). It was also lower, but without statistical significance, in cirrhotics without gallstones than in cirrhotics having gallstones. The ratio between lithiasic women and men was 0.8/1 in liver cirrhosis, as compared to 1.6/1 in noncirrhotic subjects. The proportion of pigment stones was significantly increased in liver cirrhosis (47.5%) (p less than 0.02). Chronic hemolysis secondary to hypersplenism, a know lithogenic factor in liver cirrhosis, might account for the predominance of pigment stones in this disease. Other lithogenic factors could be hyperestrogenism, changes in the proportion of biliary lipids etc. Complications of gallstones occurred less frequently in cirrhotic than in noncirrhotic patients, but complications of cholecystectomy represented the cause of death in 27.2% of cirrhotics as compared to 14.0% of noncirrhotic patients (p less than 0.02). These observations argue for a conservative, non-surgical attitude towards silent or uncomplicated gallstones in cirrhotic patient. SN - 0377-1202 UR - https://www.unboundmedicine.com/medline/citation/3704500/A_necroptic_study_of_the_prevalence_of_cholelithiasis_in_liver_cirrhosis_ L2 - https://medlineplus.gov/cirrhosis.html DB - PRIME DP - Unbound Medicine ER -