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Serum thyroid hormone, triiodothyronine, thyroxine, and triiodothyronine/thyroxine ratio in patients with fulminant, acute, and chronic hepatitis.
Am J Gastroenterol. 1986 Jun; 81(6):444-9.AJ

Abstract

The concentrations of triiodothyronine (T3), thyroxine (T4), T3/T4 ratio, free thyroxine index, and thyroxine-binding globulin were investigated in 114 viral hepatic disease patients and 36 controls. The T3/T4 ratio in healthy hepatitis B virus carriers was significantly greater than those in the controls and fulminant, acute, or chronic active hepatitis patients. The T3/T4 ratio in the fulminant hepatitis patients was significantly less than those in the controls and other liver disease patients. The correlation coefficient between the T3/T4 ratio and microsomal arylamidase activity in liver tissue from 30 patients was 0.78 (p less than 0.001). The correlation coefficient between the T3/T4 ratio and the content of cholinesterase was 0.64 (p less than 0.001). These results suggest that the T3/T4 ratio represents a marker of microsomal function and is useful for estimation of prognosis of fulminant hepatitis or differentiation of various viral hepatic diseases.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3706263

Citation

Itoh, S, et al. "Serum Thyroid Hormone, Triiodothyronine, Thyroxine, and Triiodothyronine/thyroxine Ratio in Patients With Fulminant, Acute, and Chronic Hepatitis." The American Journal of Gastroenterology, vol. 81, no. 6, 1986, pp. 444-9.
Itoh S, Yamaba Y, Oda T, et al. Serum thyroid hormone, triiodothyronine, thyroxine, and triiodothyronine/thyroxine ratio in patients with fulminant, acute, and chronic hepatitis. Am J Gastroenterol. 1986;81(6):444-9.
Itoh, S., Yamaba, Y., Oda, T., & Kawagoe, K. (1986). Serum thyroid hormone, triiodothyronine, thyroxine, and triiodothyronine/thyroxine ratio in patients with fulminant, acute, and chronic hepatitis. The American Journal of Gastroenterology, 81(6), 444-9.
Itoh S, et al. Serum Thyroid Hormone, Triiodothyronine, Thyroxine, and Triiodothyronine/thyroxine Ratio in Patients With Fulminant, Acute, and Chronic Hepatitis. Am J Gastroenterol. 1986;81(6):444-9. PubMed PMID: 3706263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum thyroid hormone, triiodothyronine, thyroxine, and triiodothyronine/thyroxine ratio in patients with fulminant, acute, and chronic hepatitis. AU - Itoh,S, AU - Yamaba,Y, AU - Oda,T, AU - Kawagoe,K, PY - 1986/6/1/pubmed PY - 1986/6/1/medline PY - 1986/6/1/entrez SP - 444 EP - 9 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 81 IS - 6 N2 - The concentrations of triiodothyronine (T3), thyroxine (T4), T3/T4 ratio, free thyroxine index, and thyroxine-binding globulin were investigated in 114 viral hepatic disease patients and 36 controls. The T3/T4 ratio in healthy hepatitis B virus carriers was significantly greater than those in the controls and fulminant, acute, or chronic active hepatitis patients. The T3/T4 ratio in the fulminant hepatitis patients was significantly less than those in the controls and other liver disease patients. The correlation coefficient between the T3/T4 ratio and microsomal arylamidase activity in liver tissue from 30 patients was 0.78 (p less than 0.001). The correlation coefficient between the T3/T4 ratio and the content of cholinesterase was 0.64 (p less than 0.001). These results suggest that the T3/T4 ratio represents a marker of microsomal function and is useful for estimation of prognosis of fulminant hepatitis or differentiation of various viral hepatic diseases. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/3706263/Serum_thyroid_hormone_triiodothyronine_thyroxine_and_triiodothyronine/thyroxine_ratio_in_patients_with_fulminant_acute_and_chronic_hepatitis_ DB - PRIME DP - Unbound Medicine ER -