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The effectiveness of metrifonate in reducing hookworm infection in Kenyan school children.
Am J Trop Med Hyg. 1986 May; 35(3):571-4.AJ

Abstract

The reduction in hookworm egg counts was determined in children treated with 1 and 2 doses of metrifonate. Kenyan primary school children were allocated to receive either 10.0 mg (n = 53) or 7.5 mg (n = 53) of metrifonate per kg of body weight (mg/kg) or a placebo (n = 26). Two doses of 10.0 mg/kg reduced hookworm egg counts (from arithmetic means of 4,177 to 438 eggs per gram of feces [epg]) more than did 2 doses of 7.5 mg/kg (from 4,329 to 1,392 epg; P less than 0.01). Two doses of metrifonate reduced egg counts more than did 1 dose (P less than 0.0001). The placebo group did not show a significant change in egg counts. The single dose of 10.0 mg/kg led to a 78% reduction in hookworm egg counts (from 4,177 to 918 epg), a level unlikely to cause iron deficiency anemia. This was as effective as 2 doses of 7.5 mg/kg, and was more easily administered than 2 or 3 doses. The further reduction after a second dose of 10.0 mg/kg (to 438 epg) is probably not of practical importance. This study shows that metrifonate, even in a single dose for treatment of S. haematobium, is also useful in reducing hookworm egg counts.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3706623

Citation

Kurz, K M., et al. "The Effectiveness of Metrifonate in Reducing Hookworm Infection in Kenyan School Children." The American Journal of Tropical Medicine and Hygiene, vol. 35, no. 3, 1986, pp. 571-4.
Kurz KM, Stephenson LS, Latham MC, et al. The effectiveness of metrifonate in reducing hookworm infection in Kenyan school children. Am J Trop Med Hyg. 1986;35(3):571-4.
Kurz, K. M., Stephenson, L. S., Latham, M. C., & Kinoti, S. N. (1986). The effectiveness of metrifonate in reducing hookworm infection in Kenyan school children. The American Journal of Tropical Medicine and Hygiene, 35(3), 571-4.
Kurz KM, et al. The Effectiveness of Metrifonate in Reducing Hookworm Infection in Kenyan School Children. Am J Trop Med Hyg. 1986;35(3):571-4. PubMed PMID: 3706623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effectiveness of metrifonate in reducing hookworm infection in Kenyan school children. AU - Kurz,K M, AU - Stephenson,L S, AU - Latham,M C, AU - Kinoti,S N, PY - 1986/5/1/pubmed PY - 1986/5/1/medline PY - 1986/5/1/entrez SP - 571 EP - 4 JF - The American journal of tropical medicine and hygiene JO - Am. J. Trop. Med. Hyg. VL - 35 IS - 3 N2 - The reduction in hookworm egg counts was determined in children treated with 1 and 2 doses of metrifonate. Kenyan primary school children were allocated to receive either 10.0 mg (n = 53) or 7.5 mg (n = 53) of metrifonate per kg of body weight (mg/kg) or a placebo (n = 26). Two doses of 10.0 mg/kg reduced hookworm egg counts (from arithmetic means of 4,177 to 438 eggs per gram of feces [epg]) more than did 2 doses of 7.5 mg/kg (from 4,329 to 1,392 epg; P less than 0.01). Two doses of metrifonate reduced egg counts more than did 1 dose (P less than 0.0001). The placebo group did not show a significant change in egg counts. The single dose of 10.0 mg/kg led to a 78% reduction in hookworm egg counts (from 4,177 to 918 epg), a level unlikely to cause iron deficiency anemia. This was as effective as 2 doses of 7.5 mg/kg, and was more easily administered than 2 or 3 doses. The further reduction after a second dose of 10.0 mg/kg (to 438 epg) is probably not of practical importance. This study shows that metrifonate, even in a single dose for treatment of S. haematobium, is also useful in reducing hookworm egg counts. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/3706623/The_effectiveness_of_metrifonate_in_reducing_hookworm_infection_in_Kenyan_school_children_ L2 - http://www.ajtmh.org/cgi/pmidlookup?view=long&pmid=3706623 DB - PRIME DP - Unbound Medicine ER -