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[Bloodletting at auricular dorsal vein combined with auricular point sticking for menstrual migraine of qi stagnation and blood stasis and its effect on serum levels of E2 and 5-HT].
Zhongguo Zhen Jiu. 2023 Apr 12; 43(4):427-31.ZZ

Abstract

OBJECTIVE

To observe the clinical effect of bloodletting at auricular dorsal vein combined with auricular point sticking on menstrual migraine (MM) of qi stagnation and blood stasis, and explore its possible mechanism.

METHODS

A total of 102 cases of MM with qi stagnation and blood stasis were randomly divided into an observation group (51 cases, 3 cases dropped off) and a control group (51 cases, 2 cases dropped off). The patients in the observation group were treated with bloodletting at auricular dorsal vein combined with auricular point sticking. The bloodletting was performed at vein at upper 1/3 of the dorsalis near the ear helix; the auricular point sticking was performed at Pizhixia (AT4), Neifenmi (CO18), Jiaogan (AH6a), Nie (AT2), Zhen (AT3), Shenmen (TF4) and Yidan (CO11). The auricular points of both ears were alternate used. From 7 days before the onset of menstruation, bloodletting at auricular dorsal vein was given once every 7 days, 3 times were taken as a course of treatment, and 1 course of treatment was given; the auricular point sticking was given once every 3 days, and 6 times of treatment were given. The patients in the control group were treated with oral administration of flunarizine hydrochloride capsules. From 7 days before the onset of menstruation, flunarizine hydrochloride was given 2 capsules per time, once a day for 3 weeks. The menstrual headache index and visual analogue scale (VAS) score of the two groups were observed before treatment, one menstrual cycle into treatment and the first and the second menstrual cycle after treatment; the migraine-specific quality of life questionnaire (MSQ) score and the serum levels of estradiol (E2) and 5-hydroxytryptamine (5-HT) were compared before treatment and one menstrual cycle into treatment; the clinical efficacy was evaluated at one menstrual cycle into treatment.

RESULTS

Compared before treatment, the menstrual headache index and VAS scores were reduced at one menstrual cycle into treatment and the first and second menstrual cycle after treatment in the two groups (P<0.05), and those in the observation group were lower than the control group (P<0.05). Compared before treatment, the MSQ scores and the serum levels of E2 and 5-HT in the two groups were increased at one menstrual cycle into treatment (P<0.05), and those in the observation group were higher than the control group (P<0.05). The total effective rate was 95.8% (46/48) in the observation group, which was higher than 73.5% (36/49) in the control group (P<0.05).

CONCLUSION

Bloodletting at auricular dorsal vein combined with auricular point sticking could relieve headache intensity, improve the quality of life in patients with MM of qi stagnation and blood stasis, which may be achieved by raising the serum levels of E2 and 5-HT to improve the level of hormone in the body.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Li R
School of Acupuncture-Moxibustion and Tuina, Shandong University of TCM, Jinan 250355, China.
Lu Y
School of Acupuncture-Moxibustion and Tuina, Shandong University of TCM, Jinan 250355, China.
Wang MM
School of Acupuncture-Moxibustion and Tuina, Shandong University of TCM, Jinan 250355, China; Department of Acupuncture and Moxibustion, Affiliated Hospital of Shandong University of TCM, Jinan 250014.
Yang DH
School of Acupuncture-Moxibustion and Tuina, Shandong University of TCM, Jinan 250355, China; Department of Acupuncture and Moxibustion, Affiliated Hospital of Shandong University of TCM, Jinan 250014; Heritage Studio of National Famous Doctors of TCM SHAN Qiu-hua, Jinan 250014, Shandong Province.

MeSH

FemaleHumansAcupuncture, EarBloodlettingSerotoninCapsulesFlunarizineQiQuality of LifeMigraine DisordersHeadacheTreatment OutcomeAcupuncture Points

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

37068820

Citation

Li, Rui, et al. "[Bloodletting at Auricular Dorsal Vein Combined With Auricular Point Sticking for Menstrual Migraine of Qi Stagnation and Blood Stasis and Its Effect On Serum Levels of E2 and 5-HT]." Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, vol. 43, no. 4, 2023, pp. 427-31.
Li R, Lu Y, Wang MM, et al. [Bloodletting at auricular dorsal vein combined with auricular point sticking for menstrual migraine of qi stagnation and blood stasis and its effect on serum levels of E2 and 5-HT]. Zhongguo Zhen Jiu. 2023;43(4):427-31.
Li, R., Lu, Y., Wang, M. M., & Yang, D. H. (2023). [Bloodletting at auricular dorsal vein combined with auricular point sticking for menstrual migraine of qi stagnation and blood stasis and its effect on serum levels of E2 and 5-HT]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, 43(4), 427-31. https://doi.org/10.13703/j.0255-2930.20221008-k0009
Li R, et al. [Bloodletting at Auricular Dorsal Vein Combined With Auricular Point Sticking for Menstrual Migraine of Qi Stagnation and Blood Stasis and Its Effect On Serum Levels of E2 and 5-HT]. Zhongguo Zhen Jiu. 2023 Apr 12;43(4):427-31. PubMed PMID: 37068820.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Bloodletting at auricular dorsal vein combined with auricular point sticking for menstrual migraine of qi stagnation and blood stasis and its effect on serum levels of E2 and 5-HT]. AU - Li,Rui, AU - Lu,Yan, AU - Wang,Meng-Meng, AU - Yang,Dian-Hui, PY - 2023/4/19/medline PY - 2023/4/17/entrez PY - 2023/4/18/pubmed KW - 5-hydroxytryptamine (5-HT) KW - auricular point sticking KW - bloodletting at auricular dorsal vein KW - estradiol (E2) KW - menstrual migraine KW - randomized controlled trial (RCT) SP - 427 EP - 31 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 43 IS - 4 N2 - OBJECTIVE: To observe the clinical effect of bloodletting at auricular dorsal vein combined with auricular point sticking on menstrual migraine (MM) of qi stagnation and blood stasis, and explore its possible mechanism. METHODS: A total of 102 cases of MM with qi stagnation and blood stasis were randomly divided into an observation group (51 cases, 3 cases dropped off) and a control group (51 cases, 2 cases dropped off). The patients in the observation group were treated with bloodletting at auricular dorsal vein combined with auricular point sticking. The bloodletting was performed at vein at upper 1/3 of the dorsalis near the ear helix; the auricular point sticking was performed at Pizhixia (AT4), Neifenmi (CO18), Jiaogan (AH6a), Nie (AT2), Zhen (AT3), Shenmen (TF4) and Yidan (CO11). The auricular points of both ears were alternate used. From 7 days before the onset of menstruation, bloodletting at auricular dorsal vein was given once every 7 days, 3 times were taken as a course of treatment, and 1 course of treatment was given; the auricular point sticking was given once every 3 days, and 6 times of treatment were given. The patients in the control group were treated with oral administration of flunarizine hydrochloride capsules. From 7 days before the onset of menstruation, flunarizine hydrochloride was given 2 capsules per time, once a day for 3 weeks. The menstrual headache index and visual analogue scale (VAS) score of the two groups were observed before treatment, one menstrual cycle into treatment and the first and the second menstrual cycle after treatment; the migraine-specific quality of life questionnaire (MSQ) score and the serum levels of estradiol (E2) and 5-hydroxytryptamine (5-HT) were compared before treatment and one menstrual cycle into treatment; the clinical efficacy was evaluated at one menstrual cycle into treatment. RESULTS: Compared before treatment, the menstrual headache index and VAS scores were reduced at one menstrual cycle into treatment and the first and second menstrual cycle after treatment in the two groups (P<0.05), and those in the observation group were lower than the control group (P<0.05). Compared before treatment, the MSQ scores and the serum levels of E2 and 5-HT in the two groups were increased at one menstrual cycle into treatment (P<0.05), and those in the observation group were higher than the control group (P<0.05). The total effective rate was 95.8% (46/48) in the observation group, which was higher than 73.5% (36/49) in the control group (P<0.05). CONCLUSION: Bloodletting at auricular dorsal vein combined with auricular point sticking could relieve headache intensity, improve the quality of life in patients with MM of qi stagnation and blood stasis, which may be achieved by raising the serum levels of E2 and 5-HT to improve the level of hormone in the body. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/37068820/[Bloodletting_at_auricular_dorsal_vein_combined_with_auricular_point_sticking_for_menstrual_migraine_of_qi_stagnation_and_blood_stasis_and_its_effect_on_serum_levels_of_E2_and_5_HT]_ DB - PRIME DP - Unbound Medicine ER -