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Screening for the influence of host factors on warfarin clearance using a single dose single sample procedure.
Int J Clin Pharmacol Ther Toxicol. 1986 Apr; 24(4):167-70.IJ

Abstract

A single dose, single sample procedure for estimating warfarin clearance for screening purposes was evaluated. Single sample estimates of warfarin clearance, CL/F, were closest to actual values for warfarin clearance, CL/F, calculated from multiple sample data when the sample was collected 120 h after warfarin ingestion. An apparent volume of distribution, V/F, of 0.17 l/kg was used in calculating CL/F. After a single dose of warfarin single sample values of CL/F averaged 0.243 l/h +/- 0.042 (N = 12) which compared well with a multiple sample-based value of CL/F which was 0.243 l/h +/- 0.046 (N = 12). When an erythromycin pretreatment was started before warfarin ingestion and continued throughout the period of warfarin elimination CL/F decreased to 0.208 l/h +/- 0.047 while CL/F decreased to 0.210 l/h +/- 0.061. Mean prediction error for CL/F relative to CL/F was -0.001 l/h with a 95% confidence interval of -0.010 to 0.009 l/h. Warfarin is a drug with pharmacokinetic characteristics enabling it to be used in a single dose single sample procedure in screening for host factor influences on its clearance.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3710629

Citation

Bachmann, K. "Screening for the Influence of Host Factors On Warfarin Clearance Using a Single Dose Single Sample Procedure." International Journal of Clinical Pharmacology, Therapy, and Toxicology, vol. 24, no. 4, 1986, pp. 167-70.
Bachmann K. Screening for the influence of host factors on warfarin clearance using a single dose single sample procedure. Int J Clin Pharmacol Ther Toxicol. 1986;24(4):167-70.
Bachmann, K. (1986). Screening for the influence of host factors on warfarin clearance using a single dose single sample procedure. International Journal of Clinical Pharmacology, Therapy, and Toxicology, 24(4), 167-70.
Bachmann K. Screening for the Influence of Host Factors On Warfarin Clearance Using a Single Dose Single Sample Procedure. Int J Clin Pharmacol Ther Toxicol. 1986;24(4):167-70. PubMed PMID: 3710629.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening for the influence of host factors on warfarin clearance using a single dose single sample procedure. A1 - Bachmann,K, PY - 1986/4/1/pubmed PY - 1986/4/1/medline PY - 1986/4/1/entrez SP - 167 EP - 70 JF - International journal of clinical pharmacology, therapy, and toxicology JO - Int J Clin Pharmacol Ther Toxicol VL - 24 IS - 4 N2 - A single dose, single sample procedure for estimating warfarin clearance for screening purposes was evaluated. Single sample estimates of warfarin clearance, CL/F, were closest to actual values for warfarin clearance, CL/F, calculated from multiple sample data when the sample was collected 120 h after warfarin ingestion. An apparent volume of distribution, V/F, of 0.17 l/kg was used in calculating CL/F. After a single dose of warfarin single sample values of CL/F averaged 0.243 l/h +/- 0.042 (N = 12) which compared well with a multiple sample-based value of CL/F which was 0.243 l/h +/- 0.046 (N = 12). When an erythromycin pretreatment was started before warfarin ingestion and continued throughout the period of warfarin elimination CL/F decreased to 0.208 l/h +/- 0.047 while CL/F decreased to 0.210 l/h +/- 0.061. Mean prediction error for CL/F relative to CL/F was -0.001 l/h with a 95% confidence interval of -0.010 to 0.009 l/h. Warfarin is a drug with pharmacokinetic characteristics enabling it to be used in a single dose single sample procedure in screening for host factor influences on its clearance. SN - 0174-4879 UR - https://www.unboundmedicine.com/medline/citation/3710629/Screening_for_the_influence_of_host_factors_on_warfarin_clearance_using_a_single_dose_single_sample_procedure_ L2 - https://medlineplus.gov/bloodthinners.html DB - PRIME DP - Unbound Medicine ER -
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